Results 71 to 80 of about 78,947 (270)

Sphingomyelin metabolism underlies Ras excitability for efficient cell migration and chemotaxis

Cell Structure and Function, 2023
In eukaryotic motile cells, the active Ras (Ras-GTP)-enriched domain is generated in an asymmetric manner on the cell membrane through the excitable dynamics of an intracellular signaling network.
Da Young Shin, Hiroaki Takagi, Michio Hiroshima, Satomi Matsuoka, Masahiro Ueda   +4 more
doaj   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

Review article

, 2019
In eukaryotic cells, the trans-Golgi network (TGN) serves as a platform for secretory cargo sorting and trafficking. In recent years, it has become evident that a complex network of lipid-lipid and lipid-protein interactions contributes to these key ...
Hausser, A., von Blume, J.
core   +1 more source

Sphingolipids as emerging mediators in retina degeneration [PDF]

, 2019
The sphingolipids ceramide (Cer), sphingosine-1-phosphate (S1P), sphingosine (Sph), and ceramide-1-phosphate (C1P) are key signaling molecules that regulate major cellular functions.
Prado Spalm, Facundo Heber, Rotstein, Nora Patricia, Simon, Maria Victoria, Vera, Marcela Sonia   +3 more
core   +1 more source

Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin [PDF]

, 2020
Streptococcus pneumoniae serotype 1 is the predominant cause of invasive pneumococcal disease in sub-Saharan Africa, but the mechanism behind its increased invasiveness is not well understood.
Baltazar, Murielle, Bricio-Moreno, Laura, Dowson, Christopher G., Everett, Dean B., Jacques, Laura C., Kadioglu, Aras, Khandaker, Shadia, Neill, Daniel R., Panagiotou, Stavros, Senghore, Madikay, Xu, Rong, Yang, Marie   +11 more
core   +4 more sources

Chinese hamster ovary cells overexpressing the oxysterol binding protein (OSBP) display enhanced synthesis of sphingomyelin in response to 25-hydroxycholesterol

Journal of Lipid Research, 1999
25-Hydroxycholesterol negatively regulates cholesterol synthesis and activates cholesterol esterification in a variety of cultured cells. Concurrent with these effects, 25-hydroxycholesterol also stimulates the synthesis of sphingomyelin in Chinese ...
Thomas A. Lagace, David M. Byers, Harold W. Cook, Neale D. Ridgway   +3 more
doaj   +1 more source

Myriocin slows the progression of established atherosclerotic lesions in apolipoprotein E gene knockout mices⃞

Journal of Lipid Research, 2008
The serine palmitoyl transferase inhibitor myriocin potently suppresses the development of atherosclerosis in apolipoprotein E (apoE) gene knockout (apoE−/−) mice fed a high-fat diet.
Elias N. Glaros, Woojin S. Kim, Carmel M. Quinn, Wendy Jessup, Kerry-Anne Rye, Brett Garner   +5 more
doaj   +1 more source

The late endocytic Rab39a GTPase regulates the interaction between multivesicular bodies and chlamydial inclusions. [PDF]

, 2015
Given their obligate intracellular lifestyle, Chlamydia trachomatis ensure their access to multiple host sources of essential lipids by interfering vesicular transport.
Capmany, Anahi, Damiani, Maria Elena, Gambarte Tudela, Julian Alberto, Goud, Bruno, Miserey Lenkei, Stephanie, Quintero, Cristian Andres, Raposo, Graça, Romao, Maryse   +7 more
core   +1 more source

Discrimination of Lipid Hydroperoxide Positional Isomers Using SFC–MS/MS With Sodium Ion: Its Application to Evaluating the Oxidation Mechanisms of Oxidized Oils

Journal of the American Oil Chemists' Society, EarlyView.
ABSTRACT Advanced lipid profiling relies on liquid chromatography–tandem mass spectrometry (LC–MS/MS), but long analysis times remain a challenge. Supercritical fluid chromatography (SFC)–MS/MS using supercritical carbon dioxide offers a faster and more environmentally friendly alternative.
Ryosuke Aoki, Masayoshi Sakaino, Junya Ito, Shunji Kato, Jun Imagi, Toshiro Sato, Kiyotaka Nakagawa   +6 more
wiley   +1 more source

Phase composition of lipoprotein SM/cholesterol/PtdCho affects FA specificity of sPLA2s

Journal of Lipid Research, 2008
We have previously reported preferential release of polyunsaturated FAs during hydrolysis of lipoprotein phosphatidylcholine (PtdCho) by group X secretory phospholipase A2 (sPLA2) and preferential release of oligounsaturated FAs during hydrolysis of ...
Arnis Kuksis, Waldemar Pruzanski
doaj   +1 more source