Results 181 to 190 of about 29,328 (213)
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Acta Haematologica, 2015
<b><i>Background/Aims:</i></b> This study investigated the priming effect of sphingosine 1-phosphate (S1P) on formyl-Met-Leu-Phe-OH (fMLP)-activated neutrophils, by specific analysis of the neutrophil respiratory burst and the signaling pathway involved in S1P activity.
Zhongying, Wang +6 more
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<b><i>Background/Aims:</i></b> This study investigated the priming effect of sphingosine 1-phosphate (S1P) on formyl-Met-Leu-Phe-OH (fMLP)-activated neutrophils, by specific analysis of the neutrophil respiratory burst and the signaling pathway involved in S1P activity.
Zhongying, Wang +6 more
openaire +2 more sources
Mechanisms of sphingosine 1-phosphate receptor signalling in cancer
Cellular Signalling, 2017S1P is a small bioactive lipid which exerts its effects following binding to a family of five G protein-coupled receptors, known as S1P1-5. Following receptor activation, multiple signalling cascades are activated, allowing S1P to regulate a range of cellular processes, such as proliferation, apoptosis, migration and angiogenesis.
Sathya Narayanan Patmanathan +4 more
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Therapeutic Potential of the Modulation of Sphingosine-1-Phosphate Receptors
Current Medicinal Chemistry, 2016It is accepted that sphingolipids (SL) are not only structural lipids in cellular membranes, but also key regulators of different cell process. Sphingosine-1-phosphate (S1P) is a member of this family involved, inter alia, in cell migration, angiogenesis and cell proliferation processes, being able to play different intracellular and extracellular ...
Antonio, Delgado +1 more
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Immune Regulation by Sphingosine 1-Phosphate and Its Receptors
Archivum Immunologiae et Therapiae Experimentalis, 2011It is well established that the lysophospholipid and signalling molecule sphingosine 1-phosphate (S1P) has many important functions in immune surveillance. S1P is produced from sphingosine by two distinct sphingosine kinases, SphK1 and SphK2, and acts as an intracellular messenger and as an extracellular ligand of five G protein-coupled cell surface ...
Constantin, Bode, Markus H, Gräler
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[Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 1 and T cell migration].
Yao xue xue bao = Acta pharmaceutica Sinica, 2018Lipid second messenger sphingosine-1-phosphate (S1P) can activate sphingosine-1-phosphate receptors (S1PRs) and participate in many biological processes, such as central nervous system homeostasis, cytokine production and T cell migration. S1PR1 is the main S1PR expressed on T cell surface.
Xin-pin, Zhuang, Qing, Zhu
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Sphingosine-1-Phosphate Receptor Modulators and Oligodendroglial Cells: Beyond Immunomodulation
International Journal of Molecular Sciences, 2020Jos Prickaerts +2 more
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