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Therapeutic Potential of the Modulation of Sphingosine-1-Phosphate Receptors
Current Medicinal Chemistry, 2016It is accepted that sphingolipids (SL) are not only structural lipids in cellular membranes, but also key regulators of different cell process. Sphingosine-1-phosphate (S1P) is a member of this family involved, inter alia, in cell migration, angiogenesis and cell proliferation processes, being able to play different intracellular and extracellular ...
Antonio, Delgado +1 more
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Immune Regulation by Sphingosine 1-Phosphate and Its Receptors
Archivum Immunologiae et Therapiae Experimentalis, 2011It is well established that the lysophospholipid and signalling molecule sphingosine 1-phosphate (S1P) has many important functions in immune surveillance. S1P is produced from sphingosine by two distinct sphingosine kinases, SphK1 and SphK2, and acts as an intracellular messenger and as an extracellular ligand of five G protein-coupled cell surface ...
Constantin, Bode, Markus H, Gräler
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[Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 1 and T cell migration].
Yao xue xue bao = Acta pharmaceutica Sinica, 2018Lipid second messenger sphingosine-1-phosphate (S1P) can activate sphingosine-1-phosphate receptors (S1PRs) and participate in many biological processes, such as central nervous system homeostasis, cytokine production and T cell migration. S1PR1 is the main S1PR expressed on T cell surface.
Xin-pin, Zhuang, Qing, Zhu
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Sphingosine-1-phosphate receptor signalling in the heart.
Cardiovascular Research, 2009Joan Heller Brown
exaly
Sphingosine 1-phosphate receptor agonists: a patent review (2010 – 2012)
Expert Opinion on Therapeutic Patents, 2013Miguel Guerrero +2 more
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