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Sphingosine-1-phosphate receptors : tools and molecular pharmacology
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Sphingosine 1-Phosphate Receptor Modulators for Multiple Sclerosis
CNS Drugs, 2021Fingolimod (Gilenya) received regulatory approval from the US FDA in 2010 as the first-in-class sphingosine 1-phosphate (S1P) receptor (S1PR) modulator and was the first oral disease-modifying therapy (DMT) used for the treatment of the relapsing forms of multiple sclerosis (MS).
Reshmi Roy +2 more
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Sphingosine-1-phosphate receptor 3 signaling.
Clinica Chimica Acta, 2021Sphingosine-1-phosphate (S1P) is a bioactive lipid which regulates a series of physiological and pathological processes via binding to five S1P receptors (S1PR1-5). Although S1PR1-3 are widely expressed, the study of S1PRs, however, mainly addressed S1PR1 and S1PR2, and few studies focus on S1PR3-5.
Qian Li +4 more
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Sphingosine 1-Phosphate Receptor Signaling
Annual Review of Biochemistry, 2009The sphingosine 1-phosphate (S1P) receptor signaling system is a productive model system. A hydrophobic zwitterionic lysophospholipid ligand with difficult physical properties interacts with five high-affinity G protein–coupled receptors to generate multiple downstream signals.
Hugh, Rosen +3 more
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Sphingosine 1-Phosphate Receptors in Cerebral Ischemia
NeuroMolecular Medicine, 2020Sphingosine 1-phosphate (S1P) is an important lipid biomolecule that exerts pleiotropic cellular actions as it binds to and activates its five G-protein-coupled receptors, S1P1-5. Through these receptors, S1P can mediate diverse biological activities in both healthy and diseased conditions. S1P is produced by S1P-producing enzymes, sphingosine kinases (
Bhakta Prasad Gaire, Ji Woong Choi
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Sphingosine 1-phosphate and its receptors in ischemia
Clinica Chimica Acta, 2021Sphingosine 1-phosphate (S1P), a metabolite of sphingolipids, is mainly derived from red blood cells (RBCs), platelets and endothelial cells (ECs). It plays important roles in regulating cell survival, vascular integrity and inflammatory responses through its receptors.
Shishu, Lu +4 more
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Neurology, 2011
Sphingosine 1-phosphate receptors (S1PRs) are G protein-coupled receptors expressed by many cell types, including immune and neural cells. These receptors are promising targets for immunomodulatory and possibly neuromodulatory therapies. Fingolimod (FTY720) is a sphingosine analog that, when phosphorylated, becomes a prototypical S1PR modulator. It has
Betty, Soliven +2 more
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Sphingosine 1-phosphate receptors (S1PRs) are G protein-coupled receptors expressed by many cell types, including immune and neural cells. These receptors are promising targets for immunomodulatory and possibly neuromodulatory therapies. Fingolimod (FTY720) is a sphingosine analog that, when phosphorylated, becomes a prototypical S1PR modulator. It has
Betty, Soliven +2 more
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Sphingosine‐1‐phosphate receptor modulators in stroke treatment
Journal of Neurochemistry, 2022AbstractSphingosine‐1‐phosphate (S1P) is a bioactive lysophospholipid that can influence a broad range of biological processes through its binding to five distinct G‐protein‐coupled receptors. S1P receptor modulators are a new group of immunosuppressive agents currently used in the immunotherapy of multiple sclerosis.
Wanzhou Zhang +3 more
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Sphingosine 1-phosphate receptors
Prostaglandins & Other Lipid Mediators, 2001Sphingosine-1-phosphate (SPP) is a bioactive lipid produced from the metabolism of sphingomyelin. It is an important constituent of serum and regulates cell growth, survival, migration, differentiation and gene expression. Its mode of action has been enigmatic; however, recent findings have shown that a family of G-protein-coupled receptors (GPCR) of ...
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Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancy
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2004Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that has recently been shown to bind cell surface S1P receptors (previously called endothelial differentiation gene (Edg) receptors), which are members of the G-protein-coupled family of receptors.
Tarek A, Taha +2 more
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