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Archives of Medical Research, 2022
Endoplasmic reticulum stress (ER stress) is involved in the development and progression of various forms of heart disease and may lead to myocardial apoptosis. Sphingosine-1-phosphate (S1P) possesses cardioprotective properties, including anti-apoptosis.
Kengquan, Chen +4 more
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Endoplasmic reticulum stress (ER stress) is involved in the development and progression of various forms of heart disease and may lead to myocardial apoptosis. Sphingosine-1-phosphate (S1P) possesses cardioprotective properties, including anti-apoptosis.
Kengquan, Chen +4 more
openaire +2 more sources
European Journal of Pharmacology, 2001
Recently, a family of G-protein-coupled receptors named endothelial differentiation gene (Edg) receptor family has been identified, which are specifically activated by the two serum lipids, sphingosine-1-phosphate and lysophosphatidic acid. Sphingosine-1-phosphate can also act intracellularly to release Ca2+ from intracellular stores.
D, Meyer zu Heringdorf +6 more
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Recently, a family of G-protein-coupled receptors named endothelial differentiation gene (Edg) receptor family has been identified, which are specifically activated by the two serum lipids, sphingosine-1-phosphate and lysophosphatidic acid. Sphingosine-1-phosphate can also act intracellularly to release Ca2+ from intracellular stores.
D, Meyer zu Heringdorf +6 more
openaire +2 more sources
2022
Sphingosine-1-phosphate (S1P) is a lipid that binds and activates five distinct receptor subtypes, S1P1, S1P2, S1P3, S1P4, S1P5, widely expressed in different cells, tissues and organs. In the cardiovascular system these receptors have been extensively studied, but no drug acting on them has been approved so far for treating cardiovascular diseases. In
Spampinato, Simona Federica +2 more
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Sphingosine-1-phosphate (S1P) is a lipid that binds and activates five distinct receptor subtypes, S1P1, S1P2, S1P3, S1P4, S1P5, widely expressed in different cells, tissues and organs. In the cardiovascular system these receptors have been extensively studied, but no drug acting on them has been approved so far for treating cardiovascular diseases. In
Spampinato, Simona Federica +2 more
openaire +4 more sources
Sphingosine 1-phosphate receptors modulate intracellular Ca2+ homeostasis
Biochemical and Biophysical Research Communications, 2007Ligation of sphingosine 1-phosphate (S1P) to a set of specific receptors named S1P receptors (S1PRs) regulates important biological processes. Although the ability of S1P to increase cytosolic Ca2+ in various cell types is well known, the role of the individual S1PRs has not been fully characterized.
RAPIZZI, ELENA +5 more
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Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism
Nature Chemical Biology, 2021Zhenmei Xu +12 more
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Vascular sphingosine-1-phosphate S1P1 and S1P3 receptors
Drug News & Perspectives, 2004The sphingolipid sphingosine-1-phosphate (S1P) acts on five subtypes of G-protein- coupled receptors, termed S1P(1) (formerly endothelial differentiation gene-1 [Edg-1]), S1P(2) (Edg-5), S1P(3) (Edg-3), S1P(4) (Edg-6) and S1P(5) (Edg-8), and possibly several other "orphan" receptors, such as GPR3, GPR6 and GPR12.
WAEBER C +2 more
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Sphingosine 1-phosphate receptor modulators in multiple sclerosis and other conditions
The Lancet, 2021Marisa P. McGinley, Jeffrey A. Cohen
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Sphingosine 1-Phosphate Receptor Subtype 1 as a Therapeutic Target for Brain Trauma
Journal of Neurotrauma, 2018Traumatic brain injury (TBI) provokes secondary pathological mechanisms, including ischemic and inflammatory processes. The new research in sphingosine 1-phosphate (S1P) receptor modulators has opened the door for an effective mechanism of reducing ...
S. Cuzzocrea +6 more
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Sphingosine 1-phosphate receptor, a new therapeutic direction in different diseases.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022Hongyu Chen +7 more
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[Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 1 and T cell migration].
Yao xue xue bao = Acta pharmaceutica Sinica, 2018Lipid second messenger sphingosine-1-phosphate (S1P) can activate sphingosine-1-phosphate receptors (S1PRs) and participate in many biological processes, such as central nervous system homeostasis, cytokine production and T cell migration. S1PR1 is the main S1PR expressed on T cell surface.
Xin-pin, Zhuang, Qing, Zhu
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