Results 201 to 210 of about 132,886 (258)

Multiomics Profiling of Toxins in the Venom of the Amazonian Spider Acanthoscurria juruenicola.

Journal of Proteome Research, 2022
Acanthoscurria juruenicola is an Amazonian spider described for the first time almost a century ago. However, little is known about their venom composition. Here, we present a multiomics characterization of A.
Erika S Nishiduka, T. F. Abreu, Fernanda Midori Abukawa, U. C. Oliveira, Caio E O Tardivo, S. M. Nascimento, G. O. Meissner, O. Chaim, M. Juliano, Eduardo S Kitano, A. Zelanis, Solange M. T. Serrano, P. D. da Silva, I. Junqueira-de-Azevedo, M. Y. Nishiyama-Jr, A. Tashima   +15 more
semanticscholar   +1 more source

Spider Venomics: Implications for Drug Discovery

Future Medicinal Chemistry, 2014
Over a period of more than 300 million years, spiders have evolved complex venoms containing an extraordinary array of toxins for prey capture and defense against predators. The major components of most spider venoms are small disulfide-bridged peptides that are highly stable and resistant to proteolytic degradation.
Pineda, Sandy S., Undheim, Eivind A. B., Rupasinghe, Darshani B., Ikonomopoulou, Maria P., King, Glenn F.   +4 more
openaire   +3 more sources

Pharmacology and biochemistry of spider venoms

Toxicon, 2002
Spider venoms represent an incredible source of biologically active substances which selectively target a variety of vital physiological functions in both insects and mammals. Many toxins isolated from spider venoms have been invaluable in helping to determine the role and diversity of neuronal ion channels and the process of exocytosis.
Rash, Lachlan D., Hodgson, Wayne C.
openaire   +3 more sources

Polypeptide neurotoxins from spider venoms

European Journal of Biochemistry, 1999
Spider venoms contain a variety of toxic components. The polypeptide toxins are divided into low and high molecular mass types. Small polypeptide toxins interacting with cation channels display spatial structure homology. They can affect the functioning of calcium, sodium, or potassium channels.
openaire   +2 more sources

Venomous snake bites, scorpions, and spiders

2014
Neurologic dysfunction due to natural neurotoxins is an important, but neglected, public health hazard in many parts of the world, particularly in the tropics. These toxins are produced by or found among a variety of live forms that include venomous snakes, arthropods such as scorpions, spiders, centipedes, stinging insects (Hymenoptera), ticks ...
S A M, Kularatne, Nimal, Senanayake
openaire   +2 more sources

Neurotoxins from Spider Venoms

2002
In his excellent book “Arachnida,” rich in learned citations, T. Savory (1) writes: “The spider is the dominant arachnid; it surpasses all others in the number and variety of its species, in the complexity of its habits, and in the breadth of its range across the world.
Alfonso Grasso, Stefano Rufini
openaire   +1 more source

Improving therapeutic potential of antibacterial spider venom peptides: coarse-grain molecular dynamics guided approach.

Future Medicinal Chemistry, 2018
AIM Spider venom is a rich source of antibacterial peptides, whose hemolytic activity is often excessive. METHODOLOGY How to get rid of it? Using latarcins from Lachesana tarabaevi and oxyopinin Oxt 4a from Oxyopes takobius spider venoms we performed ...
P. Dubovskii, A. Ignatova, P. Volynsky, I. Ivanov, M. Zhmak, A. Feofanov, R. Efremov   +6 more
semanticscholar   +1 more source

[Venomous spiders and their venoms].

Tierarztliche Praxis, 1985
The history of araneidism is long and confusing. The superstition seems to be inexterminatable that tropical mygalomorphs and mediterranean tarantulas are dangerous for humans. It can be looked up even in the most recent edition of the widespread clinical dictionary of Pschyrembel.
openaire   +1 more source

Structure and pharmacology of spider venom neurotoxins

Biochimie, 2000
Spider venoms are complex mixtures of neurotoxic peptides, proteins and low molecular mass organic molecules. Their neurotoxic activity is due to the interaction of the venom components with cellular receptors, in particular ion channels. Spider venoms have proven to be a rich source of highly specific peptide ligands for selected subtypes of potassium,
P, Escoubas, S, Diochot, G, Corzo
openaire   +2 more sources

Neuroactive Toxins of Spider Venoms

Journal of Toxicology: Toxin Reviews, 1991
AbstractA variety of neuroactive toxins have been found in the venom of spiders. The venom of Latrodectus mactans(black widow spider) is known as a potent neurotoxin, fatal to humans and animals. The effective component, α-latrotoxin (Mr=130,000) acts on the nerve terminals, causing massive release of transmitters and depletion of the synaptic vesicles,
openaire   +1 more source