Results 121 to 130 of about 76,288 (243)

Free Energy Landscapes for RBD Opening in SARS-CoV-2 Spike Glycoprotein Simulations Suggest Key Interactions and a Potentially Druggable Allosteric Pocket

, 2020
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) an enveloped, positive-sense single-stranded RNA virus that is responsible for the COVID-19 pandemic.
Stephanie, Budhan, Jose, Guerra, Lauren, Raguette, Lucy, Fallon, Yuzhang, Wang, Abbigayle, Cuomo, Carlos, Simmerling, Robert, Rizzo, Kellon, Belfon, Christopher, Corbo, Darya, Stepanenko, Sarah, Varghese   +11 more
core   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Expression, Glycosylation, and Modification of the Spike (S) Glycoprotein of SARS CoV [PDF]

, 2007
The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. To study the maturation pathway of the S glycoprotein of the severe acute respiratory syndrome (SARS)-coronavirus (CoV) within the host cell, a T7/vaccinia virus-based expression system coupled to ...
Shen, Shuo, Tan, Timothy H. P., Tan, Yee-Joo   +2 more
openaire   +2 more sources

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Homodimeric Association of the Spike Glycoproteins G1 and G2 of Uukuniemi Virus

Virology, 1995
We have studied the interactions of the G1 and G2 membrane glycoproteins of Uukuniemi virus, a bunyavirus, in virus particles and in Triton X-100-solubilized virus. The G1 glycoprotein in intact virus or in Triton solution could be oxidized into a covalent homodimer using Cu2+ ion as a catalyst.
Rönkä, Hanne, Hildén, Pekka, Von Bonsdorff, Carl-Henrik, Kuismanen, Esa   +3 more
openaire   +2 more sources

Glycan attachments on the spike glycoprotein.

The COVID-19 pandemic, driven by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spurred an urgent need for effective therapeutic interventions.
Yu-ming M. Huang (569189), Timothy Hasse (18121725), Shristi Pawnikar (10810267), Esra Mantei (18121728), Yinglong Miao (1301934), Jinan Wang (138265), Rezvan Shahoei (3807925)   +6 more
core   +1 more source

Human basigin (CD147) does not directly interact with SARS-CoV-2 spike glycoprotein

, 2021
Basigin, or CD147, has been reported as a co-receptor used by SARS-CoV-2 to invade host cells. Basigin also has a well-established role in Plasmodium falciparum malaria infection of human erythrocytes where it is bound by one of the parasite’s invasion ...
Brun, Juliane, Draper, Simon J, Ragotte, Robert J, Pulido, David, Donnellan, Francesca R, Davies, Hannah, Gorini, Giacomo, Skinner, Katherine, King, Lloyd DW   +8 more
core   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

SARS-CoV-2 Omicron Spike shows strong binding affinity and favourable interaction landscape with the TLR4/MD2 compared to other variants

Journal of Genetic Engineering and Biotechnology
Emergences of SARS-CoV-2 variants have made the pandemic more critical. Toll-like receptor 4 (TLR4) recognizes the molecular patterns of pathogens and activates the production of proinflammatory cytokines to restrain the infection.
Chiranjib Chakraborty, Bidyut Mallick, Manojit Bhattacharya, Siddappa N. Byrareddy   +3 more
doaj   +1 more source

Computational Docking Study of the Phytochemical Constituent, Silybin (Silybum marianum) against SARS-CoV-2 Omicron Variant Spike Glycoprotein: An In-silico Approach

, 2023
SARS-CoV-2 is continually evolving with the emergence of new variants with increased viral pathogenicity. The emergence of heavily mutated Omicron (B.1.1.529) with spike protein mutations are known to mediate its higher transmissibility and immune escape
Abhijit Dey, Aanchal Sharma, Deepak Chandran, Poonam Bansal, Raman Kumar, Kuldeep Dhama, Anil K Sharma, Seema Ramniwas, Varruchi Sharma, Anil Panwar   +9 more
core   +1 more source