Results 121 to 130 of about 73,847 (203)
Advanced Science, Volume 13, Issue 43, 3 August 2026.Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang +17 more
wiley +1 more source
Deep Mutational Scanning for the Study and Engineering of Protein Assemblies
Chemistry–Methods, Volume 6, Issue 8, August 2026.This review explores how deep mutational scanning (DMS) can be used to improve understanding and accelerate engineering of protein assemblies, from natural fibers to engineered nanocages. We discuss various types of protein assemblies and their characterization, provide an introduction to the DMS technique, and then highlight examples in which DMS has ...
Jenna B. Wolfanger +2 more
wiley +1 more source
Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.CD155 is identified as a key driver of anti‐PD‐1 resistance in NSCLC. CD155 promotes tumour glycolysis and malignant progression via the PI3K/AKT/HIF‐1α signalling axis. AAV9_shCD155 combined with anti‐PD‐1 markedly inhibits tumour growth and promotes immune infiltration. Abstract Objective Anti‐PD‐1 therapy resistance remains a critical barrier in non‐
Wei‐Guang Du +11 more
wiley +1 more source
SARS‐CoV‐2 Spike Peptides Trigger Nociceptive Responses Through Spinal TLR4 Pathways
European Journal of Pain, Volume 30, Issue 7, August 2026.ABSTRACT Background Pain is a common neurological manifestation of COVID‐19, yet the mechanisms by which SARS‐CoV‐2 spike protein fragments contribute to nociceptive processing remain poorly understood. We investigated whether spike‐derived peptides directly activate spinal neuroimmune pathways involved in pain signalling.
Bruno Eduardo Silva +15 more
wiley +1 more source
Electrochemical Science Advances, Volume 6, Issue 4, August 2026.CD63‑aptamer zinc–adenine metal‐organic framework (CD63@ZnMOF) captures and concentrates extracellular vesicles (EVs) from serum before transfer to a VCAM‑1 aptamer‑modified gold electrode. This dual‐aptamer design enables specific detection of VCAM‑1+CD63+ endothelial EVs without additional redox labelling probes.
Cong Minh Nguyen +2 more
wiley +1 more source
Journal of Medical Virology, Volume 98, Issue 8, August 2026.ABSTRACT This study examined changes in anti‐Spike (anti‐S) antibodies (Abs) and type I interferon (IFN‐I) following the BNT162b2 vaccine in people living with HIV (PLWH) and analyzed the impact of demographic and immunological factors. In total, 75 PLWH and 28 healthy donors were followed at baseline (T0), at the second dose (T1), after the second ...
Federica Frasca +18 more
wiley +1 more source
A Computational Workflow to Predict Biological Target Mutations: The Spike Glycoprotein Case Study. [PDF]
Molecules, 2023 Cozzini P +3 more
europepmc +1 more source
Expanding the Genotypic Spectrum of POMGNT1‐Related Muscle‐Eye‐Brain Disease: A Case Report
Molecular Genetics &Genomic Medicine, Volume 14, Issue 8, August 2026.Compound heterozygous variants in the POMGNT1 gene expand the genotypic spectrum of Muscle‐Eye‐Brain disease, highlighting severe epilepsy with status epilepticus. Despite long disease duration, seizure freedom was achieved with intensive antiseizure polytherapy, underscoring the importance of continued therapeutic optimization in dystroglycanopathies.
Evripidis Pityrigkas +6 more
wiley +1 more source
CoCryoViS: Collaborative online cryo‐electron tomography visualization system
Protein Science, Volume 35, Issue 8, August 2026.Abstract We present a collaborative, interactive, web‐based visualization and processing system for Cryo‐Electron Tomography (cryo‐ET) data that supports the complete workflow, from raw tilt‐series projections to final 3D segmentations. The system integrates tilt‐series alignment, motion correction, tomographic reconstruction, manual and pseudo ...
Omar Mena +8 more
wiley +1 more source
Small Science, Volume 6, Issue 8, August 2026.Quantum‐capacitance biosensing enables real‐time monitoring of naxitamab in patient samples via laser‐fabricated electrodes and single‐point calibration. The proposed platform provides rapid and sensitive quantification, with the potential to enable therapeutic drug monitoring and patient stratification according to circulating naxitamab levels, while ...
Andy Bruno +8 more
wiley +1 more source