Results 61 to 70 of about 2,427,104 (377)

Perturbation of membrane dynamics in nerve cells as an early event during bilirubin-induced apoptosis

Journal of Lipid Research, 2002
Increased levels of unconjugated bilirubin, the end product of heme catabolism, impair crucial aspects of nerve cell function. In previous studies, we demonstrated that bilirubin toxicity may be due to cell death by apoptosis.
Cecília M.P. Rodrigues, Susana Solá, Rui E. Castro, Pedro A. Laires, Dora Brites, José J.G. Moura   +5 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Probing Small-Angle Molecular Motions with EPR Spectroscopy: Dynamical Transition and Molecular Packing in Disordered Solids

Magnetochemistry, 2022
Disordered molecular solids present a rather broad class of substances of different origin—amorphous polymers, materials for photonics and optoelectronics, amorphous pharmaceutics, simple molecular glass formers, and others.
Sergei A. Dzuba
doaj   +1 more source

Antisymmetry in Strangeness -1 and -2 Three-Baryon Systems

, 2000
Using the generalized Pauli principle by adding particle labels to the usual space and spin labels a symmetric Hamiltonian and a corresponding antisymmetric wavefunction is constructed for systems of three baryons in the strangeness sectors $S=-1$ and -2.
Gloeckle, W., Miyagawa, K.
core   +1 more source

Superselective pseudocontinuous arterial spin labeling [PDF]

Magnetic Resonance in Medicine, 2010
AbstractA new technique for the imaging of flow territories of individual extra‐ and intracranial arteries is presented. The method is based on balanced pseudocontinuous arterial spin labeling but employs additional time‐varying gradients in between the radiofrequency pulses of the long labeling train. The direction of the additional gradient vector is
Helle, M., Norris, D.G., Rufer, S., Alfke, K., Jansen, O., Osch, M.J.P. van   +5 more
openaire   +4 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Topological phase transitions in ultra-cold Fermi superfluids: the evolution from BCS to BEC under artificial spin-orbit fields

, 2011
We discuss topological phase transitions in ultra-cold Fermi superfluids induced by interactions and artificial spin orbit fields. We construct the phase diagram for population imbalanced systems at zero and finite temperatures, and analyze spectroscopic
C. A. R. Sá de Melo, E. M. Lifshitz, E. M. Lifshitz, G. E. Volovik, I. M. Lifshitz, Kangjun Seo, Li Han, M. Nakahara   +7 more
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Rigid and stable nitroxide spin label for high-resolution distance measurements on proteins by DEER experiments

Magnetic Resonance Letters
The distance distributions between two site-specifically anchored spin labels in a protein, measured by pulsed electron-electron double resonance (PELDOR or DEER), provide rich sources of structural and conformational restraints on the proteins or their ...
Ya-Ting Chen, Xing Zhang, Jia-Liang Chen, Bin-Bin Pan, Daniella Goldfarb, Yin Yang, Xun-Cheng Su   +6 more
doaj   +1 more source