Results 71 to 80 of about 30,422 (298)
Beilstein Journal of Organic Chemistry, 2018 TEMPO spin labels protected with 2-nitrobenzyloxymethyl groups were attached to the amino residues of three different nucleosides: deoxycytidine, deoxyadenosine, and adenosine.
Timo Weinrich +4 more
doaj +1 more source
Estimation of Absolute Spin Counts in Nitronyl Nitroxide-Bearing Graphene Nanoribbons
Magnetochemistry, 2019 The degrees of spin labeling of a polyphenylene-based polymer and its graphitized derivative with a stable nitronyl nitroxide were evaluated by estimating the absolute numbers of spins in a set of samples using continuous wave (CW) electron spin ...
Dmitri Stass, Evgeny Tretyakov
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
EPR investigations of organic non-covalent assemblies with spin labels and spin probes [PDF]
, 2011 The object of the present report is to review the articles appeared in the literature in the last few years describing the use of EPR spectroscopy to investigate the properties of purely organic non-covalent assemblies in liquid solution with spin labels
LUCARINI, MARCO, MEZZINA, ELISABETTA
core +1 more source
Probing the Y2 Receptor on Transmembrane, Intra- and Extra-Cellular Sites for EPR Measurements
Molecules, 2020 The function of G protein-coupled receptors is intrinsically linked to their conformational dynamics. In conjugation with site-directed spin labeling, electron paramagnetic resonance (EPR) spectroscopy provides powerful tools to study the highly dynamic ...
Jeannette M. Laugwitz +6 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Distance measurements using pulsed EPR: Noncovalently bound nitroxide and trityl spin labels [PDF]
, 2013 The function of biomacromolecules is controlled by their structure and conformational flexibility. Investigating the structure of biologically important macromolecules can, therefore, yield information that could explain their complex biological function.
Gunnar Widtfeldt Reginsson 1976-
core +2 more sources
Frontiers in Molecular Biosciences, 2015 Proteins are highly variable biological systems, not only in their structures but also in their dynamics. The most extreme example of dynamics is encountered within the family of Intrinsically Disordered Proteins (IDPs), which are proteins lacking a well-
Nolwenn eLe Breton +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
The Influence of Blood and Serum Microenvironment on Spin-Labeled Magnetic Nanoparticles
MagnetismThe investigation and clarification of the properties of surface-functionalized superparamagnetic nanoparticles in a biological environment are key challenges prior to their medical applications.
Tomasz Kubiak
doaj +1 more source