Results 31 to 40 of about 189,667 (257)

Integrated cryopreservation-thawing-transplantation platform for neural stem cell-based spinal cord injury repair

Bioactive Materials
Spinal cord injury (SCI) repair lacks clinically validated restorative therapies. Transplantation of exogenous neural stem cells (NSCs) offers significant potential for therapeutic applications; however, challenges remain, including substantial cell loss,
Jie Ren, Junjin Li, Hongda Wang, Haiwen Feng, Huaying Hao, Junyu Chen, Yuanquan Li, Zhengyu Xu, Chuanhao Li, Wang Jiang, Yan Wang, Xiaoyang Zhang, Xiaomeng Song, Guangzhi Ning, Jun Liang, Shiqing Feng   +15 more
doaj   +1 more source

RhoA/Rho kinase in spinal cord injury

Neural Regeneration Research, 2016
A spinal cord injury refers to an injury to the spinal cord that is caused by a trauma instead of diseases. Spinal cord injury includes a primary mechanical injury and a much more complex secondary injury process involving inflammation, oxidation ...
Xiangbing Wu, Xiao-ming Xu
doaj   +1 more source

A potential target gene CD63 for different degrees of intervertebral disc degeneration

Scientific Reports, 2022
Understanding molecular mechanisms of intervertebral disc degeneration (IDD) and providing a novel target for the treatment of IDD have important implications. We sought to explore a new promising gene target for the treatment of IDD.
Sheng Gao, Shu Jia, Xutao Fan, Chengcan Gao, Qingwei Li, Yuxue Wu, Chunyang Meng   +6 more
doaj   +1 more source

Spinal dystonia and other spinal movement disorders

Dystonia, 2023
While traditionally considered a disorder of the basal ganglia, brainstem, and cerebellum, multiple reports have shown that spinal cord pathologies may lead to dystonia.
Shlok Sarin, Shlok Sarin, Temitope Lawal, Hesham Abboud, Hesham Abboud   +4 more
doaj   +1 more source

The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo, Miriam A. Bornhorst, Angela J. Waanders, Sara Zarnegar‐Lumley, Ashwin Lakshman Koppayi, Lucy A. Godley   +5 more
wiley   +1 more source

Phillygenin inhibits neuroinflammation and promotes functional recovery after spinal cord injury via TLR4 inhibition of the NF-κB signaling pathway

Journal of Orthopaedic Translation
Background: Spinal cord injuries (SCIs) trigger a cascade of detrimental processes, encompassing neuroinflammation and oxidative stress (OS), ultimately leading to neuronal damage.
Yu Zhang, Shining Xiao, Fan Dan, Geliang Yao, Shu'e Hong, Jiaming Liu, Zhili Liu   +6 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

FractalSpiNet: Fractal-Based U-Net for Automatic Segmentation of Cervical Spinal Cord and MS Lesions in MRI

IEEE Access
The spinal cord is an important part of the central nervous system, responsible for transmitting nerve signals throughout the body. The cervical spinal cord contains eight nerve bundles located in the neck region of the spinal cord that transmit to the ...
Rukiye Polattimur, Emre Dandil, Mehmet Suleyman Yildirim, Suleyman Ulucay, Utku Senol   +4 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source