Results 61 to 70 of about 2,689,938 (292)

Spinal dystonia and other spinal movement disorders

Dystonia, 2023
While traditionally considered a disorder of the basal ganglia, brainstem, and cerebellum, multiple reports have shown that spinal cord pathologies may lead to dystonia.
Shlok Sarin, Shlok Sarin, Temitope Lawal, Hesham Abboud, Hesham Abboud   +4 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Phillygenin inhibits neuroinflammation and promotes functional recovery after spinal cord injury via TLR4 inhibition of the NF-κB signaling pathway

Journal of Orthopaedic Translation
Background: Spinal cord injuries (SCIs) trigger a cascade of detrimental processes, encompassing neuroinflammation and oxidative stress (OS), ultimately leading to neuronal damage.
Yu Zhang, Shining Xiao, Fan Dan, Geliang Yao, Shu'e Hong, Jiaming Liu, Zhili Liu   +6 more
doaj   +1 more source

Neurogenesis and apoptosis in the developmentally regulated loss of spinal cord regeneration. [PDF]

, 2006
Unlike the adult mammal, the chick can successfully regenerate its spinal cord until embryonic day (E) 13. Multiple factors may contribute to the subsequent loss of regenerative capacity, although most research has concentrated on axonal re-growth ...
Whalley, K.A., Whalley, Katherine Ann
core  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source

Biomechanical advantages of double-trajectory screws technique combined with multiple-rod constructs in lumbar pedicle subtraction osteotomy: a finite element analysis study

Frontiers in Bioengineering and Biotechnology
IntroductionAlthough multi-rods constructs (Multi-RCs) have been demonstrated to reduce the risk of rod fracture (RF) following pedicle subtraction osteotomy (PSO), they offer limited improvement in terms of screw-related complications.
Hu Lyu, Hu Lyu, Hu Lyu, Qiyang Wang, Qiyang Wang, Qiyang Wang, Hongbang Liu, Hongbang Liu, Hongbang Liu, Fengyi Jiang, Fengyi Jiang, Fengyi Jiang, Tiannan Zou, Tiannan Zou, Tiannan Zou, Qiunan Lyu, Qiunan Lyu, Qiunan Lyu   +17 more
doaj   +1 more source

Robotics Training Algorithms for Optimizing Motor Learning in Spinal Cord Injured Subjects [PDF]

, 2007
The circuitries within the spinal cord are remarkably robust and plastic. Even in the absence of supraspinal control, such circuitries are capable of generating functional movements and changing their level of excitability based on a specific ...
Cai, Lance Lin-Lan
core   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

FractalSpiNet: Fractal-Based U-Net for Automatic Segmentation of Cervical Spinal Cord and MS Lesions in MRI

IEEE Access
The spinal cord is an important part of the central nervous system, responsible for transmitting nerve signals throughout the body. The cervical spinal cord contains eight nerve bundles located in the neck region of the spinal cord that transmit to the ...
Rukiye Polattimur, Emre Dandil, Mehmet Suleyman Yildirim, Suleyman Ulucay, Utku Senol   +4 more
doaj   +1 more source