Results 81 to 90 of about 325,167 (345)

ALS mutant FUS proteins are recruited into stress granules in induced pluripotent stem cells- derived motoneurons [PDF]

, 2015
Patient-derived induced Pluripotent Stem Cells (iPSCs) provide an opportunity to study human diseases mainly in those cases where no suitable model systems are available.
Bozzoni, Irene, Caliendo, Virginia, Calvo, Andrea, Chiò, Adriano, DE SANTIS, Riccardo, Laneve, Pietro, Lenzi, Jessica, Morlando, Mariangela, Rosa, Alessandro, Turris, Valeria de   +9 more
core   +4 more sources

Dorsolateral Cervical Cord T2 Hyperintensity in KIF1C‐Related Disease (Spastic Paraplegia 58): Two Long‐Duration Cases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Pathogenic variants in KIF1C cause Spastic Paraplegia 58 (SPG58), typically presenting with cerebellar ataxia and spastic paraparesis. We report two unrelated patients with spastic paraparesis, cerebellar ataxia, and tremor. Whole‐exome sequence analysis identified novel homozygous variants in the motor domain of KIF1C (NM_006612.6): c.921G>A (
Akihiko Mitsutake, Masao Osaki, Takashi Matsukawa, Miho Osako, Chisen Takeuchi, Hiroyuki Ishiura, Jun Mitsui, Ryo Kurokawa, Harushi Mori, Yuji Takahashi, Jun Goto, Shoji Tsuji, Tatsushi Toda   +12 more
wiley   +1 more source

Myelopathy as the first manifestation of AIDS

AIDS Research and Therapy
Background Human immunodeficiency virus (HIV) is a retrovirus mainly infecting immune cells. Central nervous system diseases in HIV-infected patients can be caused by HIV or opportunistic infections. Neurological diseases associated with HIV have diverse
Yuanyuan Li, Qianru Yang, Hong Lin, Qiong Zhou, Fangfang Ge, Jiankuan Shi   +5 more
doaj   +1 more source

Water channels in the brain and spinal cord—overview of the role of aquaporins in traumatic brain injury and traumatic spinal cord injury

Frontiers in Cellular Neuroscience
Knowledge about the mechanisms underlying the fluid flow in the brain and spinal cord is essential for discovering the mechanisms implicated in the pathophysiology of central nervous system diseases.
Thea Overgaard Wichmann, Marie Hedegaard Højsager, Helle Hasager Damkier   +2 more
doaj   +1 more source

Laboratory Signs of Enteric Failure - Predictors of Pressure Ulcers in Traumatic Spinal Cord Disease [PDF]

, 2021
M. S. Baleev, М. G. Ryabkov, O. Perlmutter, Alexander Petrovich Fraerman, I. Smirnov, Andrey E. Leontiev, G. Е. Sheiko, O. I. Efanov   +7 more
openalex   +1 more source

Age related diffusion and tractography changes in typically developing pediatric cervical and thoracic spinal cord [PDF]

, 2018
Background and objective: Diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT) are two techniques that can measure white matter integrity of the spinal cord. Recently, DTI indices have been shown to change with age.
Alizadeh, Mahdi, Conklin, PhD, Chris, Faro, Scott H., Finsterbusch, Jürgen, Fisher, Joshua, Flanders, Adam, Krisa, PhD, Laura, Middleton, Devon, Mohamed, PhD, Feroze, Mulcahey, M. J., Saksena, PhD, Sona, Sultan, Yusra   +11 more
core   +3 more sources

Daratumumab Treatment for Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP): A Case Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune‐mediated neuropathy featuring progressive weakness, sensory deficits, and areflexia. While corticosteroids, intravenous immunoglobulin, and plasmapheresis are effective first‐line immunotherapies, a subset of patients remains treatment‐refractory.
Xueyu Zhang, Jianli Zhao, Xue Zhao, Xiaowei Hu, Zichun Xiao, Jie Wu, Xiaowen Li, Jing Xu, Yu‐Jing Li   +8 more
wiley   +1 more source

Amyotrophic Lateral Sclerosis [PDF]

, 2019
The word amyotrophic is derived from Greek, and means “without nourishment to muscles”, lateral means to the sides and sclerosis means hardened (“What is ALS?,” n.d.).
Georgetson, Anastasia M.
core   +1 more source

Evaluation of the Efficacy and Safety of Satralizumab in a Pregnant NMOSD Patient With AQP4/MOG‐IgG Dual Seropositive: A Case Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Neuromyelitis Optica Spectrum Disorder (NMOSD) is a chronic autoimmune neuroinflammatory disease, typically characterized by antibodies against aquaporin 4 (AQP4‐IgG) or myelin oligodendrocyte glycoprotein (MOG‐IgG). Simultaneous seropositivity for both antibodies in a single patient is exceedingly rare.
Yeting Luo, Shuhua Xie, Xianghong Liu
wiley   +1 more source

Intramedullary cysticercosis

Journal of Dr. NTR University of Health Sciences, 2020
Neurocysticercosis is one of the most common parasitic diseases of the central nervous system. However, spinal involvement is rare. Here, we report the case of a 28-year-old man with intramedullary cysticercosis in the cervical spinal cord.
J Suneeth, Nimmagadda L Moorthy, Gollapudi P Rao, Doli M Chander, N Anil Kumar   +4 more
doaj   +1 more source