Results 11 to 20 of about 732,175 (355)

Progression in translational research on spinal cord injury based on microenvironment imbalance

Bone Research, 2022
Spinal cord injury (SCI) leads to loss of motor and sensory function below the injury level and imposes a considerable burden on patients, families, and society. Repair of the injured spinal cord has been recognized as a global medical challenge for many
Baoyou Fan, Zhijian Wei, Shiqing Feng
doaj   +2 more sources

Spinal cord injury: molecular mechanisms and therapeutic interventions

Signal Transduction and Targeted Therapy, 2023
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate. The challenges of SCI repair include its complex pathological mechanisms and the difficulties of neural regeneration in the central nervous system.
Xiao Hu, Wei Xu, Yilong Ren, Zhaojie Wang, Xiaolie He, Runzhi Huang, Bei Ma, Jingwei Zhao, Rongrong Zhu, Liming Cheng   +9 more
semanticscholar   +1 more source

Walking naturally after spinal cord injury using a brain–spine interface

Nature, 2023
A reliable digital bridge restored communication between the brain and spinal cord and enabled natural walking in a participant with spinal cord injury. A spinal cord injury interrupts the communication between the brain and the region of the spinal cord
H. Lorach, Andrea Gálvez, Valeria Spagnolo, Félix Martel, Serpil Karakas, Nadine Intering, M. Vat, Olivier Faivre, C. Harte, Salif Komi, Jimmy Ravier, Thibault Collin, Laure Coquoz, Icare Sakr, Edeny Baaklini, Sergio D. Hernandez-Charpak, Grégory Dumont, R. Buschman, Nicholas Buse, T. Denison, I. V. van Nes, L. Asboth, A. Watrin, L. Struber, F. Sauter-Starace, Lilia Langar, V. Auboiroux, S. Carda, S. Chabardès, T. Aksenova, Robin Demesmaeker, G. Charvet, J. Bloch, G. Courtine   +33 more
semanticscholar   +1 more source

The PI3K/AKT signalling pathway in inflammation, cell death and glial scar formation after traumatic spinal cord injury: Mechanisms and therapeutic opportunities

Cell Proliferation, 2022
Traumatic spinal cord injury (TSCI) causes neurological dysfunction below the injured segment of the spinal cord, which significantly impacts the quality of life in affected patients.
Xuegang He, Ying Li, Bo Deng, Ai-xin Lin, Guangzhi Zhang, Miao Ma, Yonggang Wang, Yong Yang, Xuewen Kang   +8 more
semanticscholar   +1 more source

International Standards for Neurological Classification of Spinal Cord Injury: Revised 2019.

Topics in Spinal Cord Injury Rehabilitation, 2021
This booklet contains the eighth edition of the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) that describes the examination (referred to as the International Standards examination) as well as the classification ...
R. Rupp, F. Biering-Sørensen, S. Burns, D. Graves, J. Guest, L. Jones, M. Read, G. Rodriguez, C. Schuld, Keith E Tansey-Md, K. Walden, S. Kirshblum   +11 more
semanticscholar   +1 more source

Inflammation after spinal cord injury: a review of the critical timeline of signaling cues and cellular infiltration

Journal of Neuroinflammation, 2021
Traumatic spinal cord injury (SCI) is a devastating neurological condition that results in a loss of motor and sensory function. Although extensive research to develop treatments for SCI has been performed, to date, none of these treatments have produced
Daniel J. Hellenbrand, Charlie Quinn, Zachariah J. Piper, Carolyn N. Morehouse, J. Fixel, Amgad S. Hanna   +5 more
semanticscholar   +1 more source

Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury

Signal Transduction and Targeted Therapy, 2022
Spinal cord injury (SCI) involves diverse injury responses in different cell types in a temporally and spatially specific manner. Here, using single-cell transcriptomic analyses combined with classic anatomical, behavioral, electrophysiological analyses,
Chen Li, Zhourui Wu, Liqiang Zhou, Jingliang Shao, Xiao Hu, Wei Xu, Yilong Ren, Xingfei Zhu, W. Ge, Kunshan Zhang, Jiping Liu, Runzhi Huang, Jing Yu, Dandan Luo, Xuejiao Yang, Wenmin Zhu, Rongrong Zhu, Changhong Zheng, Y. Sun, Liming Cheng   +19 more
semanticscholar   +1 more source

Spinal Cord Injury: Pathophysiology, Multimolecular Interactions, and Underlying Recovery Mechanisms

International Journal of Molecular Sciences, 2020
Spinal cord injury (SCI) is a destructive neurological and pathological state that causes major motor, sensory and autonomic dysfunctions. Its pathophysiology comprises acute and chronic phases and incorporates a cascade of destructive events such as ...
A. Anjum, Muhammad Da'in Yazid, Muhammad Fauzi Daud, Jalilah Idris, A. M. Ng, Amaramalar Selvi Naicker, Ohnmar Htwe Rashidah Ismail, Ramesh Kumar Athi Kumar, Y. Lokanathan   +8 more
semanticscholar   +1 more source

Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain

Nature Communications, 2022
Activation of microglia in the spinal cord following peripheral nerve injury is critical for the development of long-lasting pain hypersensitivity. However, it remains unclear whether distinct microglia subpopulations or states contribute to different ...
Shannon N Tansley, Sonali Uttam, Alba Ureña Guzmán, Moein Yaqubi, Alain S Pacis, M. Parisien, Haley Deamond, Calvin Wong, O. Rabau, Nicole Brown, L. Haglund, J. Ouellet, Carlo Santaguida, A. Ribeiro-da-Silva, Soroush Tahmasebi, M. Prager-Khoutorsky, J. Ragoussis, Ji Zhang, M. Salter, L. Diatchenko, Luke M. Healy, J. Mogil, A. Khoutorsky   +22 more
semanticscholar   +1 more source

Zinc attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury by activating Nrf2/GPX4 defense pathway

CNS Neuroscience & Therapeutics, 2021
Spinal cord injury (SCI) involves multiple pathological processes. Ferroptosis has been shown to play a critical role in the injury process. We wanted to explore whether zinc can inhibit ferroptosis, reduce inflammation, and then exert a neuroprotective ...
Ming-hao Ge, He Tian, Liang Mao, Daoyong Li, Jiaquan Lin, Hengshuo Hu, Shuo Huang, Chuanjie Zhang, X. Mei   +8 more
semanticscholar   +1 more source