Results 31 to 40 of about 723,074 (354)

Opposite modulation of functional recovery following contusive spinal cord injury in mice with oligodendrocyte-selective deletions of Atf4 and Chop/Ddit3

Scientific Reports, 2023
The integrated stress response (ISR)-activated transcription factors ATF4 and CHOP/DDIT3 may regulate oligodendrocyte (OL) survival, tissue damage and functional impairment/recovery in white matter pathologies, including traumatic spinal cord injury (SCI)
Yonglin Gao, George Z. Wei, Michael D. Forston, Benjamin Rood, Emily R. Hodges, Darlene Burke, Kariena Andres, Johnny Morehouse, Christine Armstrong, Charles Glover, Lukasz P. Slomnicki, Jixiang Ding, Julia H. Chariker, Eric C. Rouchka, Sujata Saraswat Ohri, Scott R. Whittemore, Michal Hetman   +16 more
doaj   +1 more source

Microdialysis to optimize cord perfusion and drug delivery in spinal cord injury. [PDF]

, 2016
OBJECTIVE: There is lack of monitoring from the injury site to guide management of patients with acute traumatic spinal cord injury. Here we describe a bedside microdialysis monitoring technique for optimizing spinal cord perfusion and drug delivery at ...
Abrahamsson, Abrahamsson, Balis, Bernards, Bracken, Bracken, Carpenter, Casha, Dahyot-Fizelier, Fehlings, Fehlings, Frasca, Hutchinson, Hutchinson, Inoue, Kitagawa, Kobayakawa, Lee, Okon, Papadopoulos, Phang, Phang, Phang, Phang, Plock, Quan, Saadoun, Saadoun, Shannon, Timofeev, Vandenabeele, Varsos, Walters, Werndle, Werndle, Werndle   +35 more
core   +1 more source

Effects of diet and/or exercise in enhancing spinal cord sensorimotor learning. [PDF]

, 2012
Given that the spinal cord is capable of learning sensorimotor tasks and that dietary interventions can influence learning involving supraspinal centers, we asked whether the presence of omega-3 fatty acid docosahexaenoic acid (DHA) and the curry spice ...
Bhatia, Harsharan S, Cruz, Rusvelda, Edgerton, V Reggie, Gomez-Pinilla, Fernando, Joseph, M Selvan, Roy, Roland R, Tillakaratne, Niranjala JK, Wu, Aiguo, Ying, Zhe, Zhong, Hui, Zhuang, Yumei   +10 more
core   +5 more sources

Schwann cell-derived exosomes containing MFG-E8 modify macrophage/microglial polarization for attenuating inflammation via the SOCS3/STAT3 pathway after spinal cord injury

Cell Death and Disease, 2023
Macrophage/microglia polarization acts as an important part in regulating inflammatory responses in spinal cord injury (SCI). However, the regulation of inflammation of Schwann cell-derived exosomes (SCDEs) for SCI repair is still unclear.
Jie Ren, Bin Zhu, Guangjin Gu, Wencan Zhang, Junjin Li, Hongda Wang, Min Wang, Xiaomeng Song, Zhijian Wei, Shiqing Feng   +9 more
doaj   +1 more source

Neurotropin exerts neuroprotective effects after spinal cord injury by inhibiting apoptosis and modulating cytokines

Journal of Orthopaedic Translation, 2021
Background/objective: Spinal cord injury (SCI) severely and irreversibly damages the central nervous system. Neurotropin (NTP), a nonprotein extract obtained from inflamed rabbit skin inoculated with vaccinia virus, is a drug that has been used for more ...
Xue Yao, Chao Sun, Baoyou Fan, Chenxi Zhao, Yan Zhang, Huiquan Duan, Yilin Pang, Wenyuan Shen, Bo Li, Xu Wang, Chang Liu, Hengxing Zhou, Xiaohong Kong, Shiqing Feng   +13 more
doaj   +1 more source

Iatrogenic Spinal Cord Injury Resulting From Cervical Spine Surgery. [PDF]

, 2017
STUDY DESIGN: Retrospective cohort study of prospectively collected data. OBJECTIVE: To examine the incidence of iatrogenic spinal cord injury following elective cervical spine surgery.
Arnold, Paul M., Buser, Zorica, Currier, Bradford L., Daniels, Alan H., Fehlings, Michael G., Fish, David E., Hart, Robert A., Hilibrand, Alan S., Lord, Elizabeth L., Mroz, Thomas E., Nassr, Ahmad, Riew, K. Daniel, Sebastian, Arjun S., Stroh, D. Alex, Tortolani, P. Justin, Wang, Jeffrey C.   +15 more
core   +2 more sources

Preserved gait kinematics during controlled body unloading

Journal of NeuroEngineering and Rehabilitation, 2017
Background Body weight supported locomotor training was shown to improve walking function in neurological patients and is often performed on a treadmill.
L. Awai, M. Franz, C. S. Easthope, H. Vallery, A. Curt, M. Bolliger   +5 more
doaj   +1 more source

Limited Functional Effects of Subacute Syngeneic Bone Marrow Stromal Cell Transplantation after Rat Spinal Cord Contusion Injury

Cell Transplantation, 2016
Cell transplantation might be one means to improve motor, sensory, or autonomic recovery after traumatic spinal cord injury (SCI). Among the different cell types evaluated to date, bone marrow stromal cells (BMSCs) have received considerable interest due
Beatrice Sandner, Mareva Ciatipis, Melanie Motsch, Irina Soljanik, Norbert Weidner, Armin Blesch Ph.D.   +5 more
doaj   +1 more source

Investigation of perfusion impairment in degenerative cervical myelopathy beyond the site of cord compression

Scientific Reports, 2023
The aim of this study was to determine tissue-specific blood perfusion impairment of the cervical cord above the compression site in patients with degenerative cervical myelopathy (DCM) using intravoxel incoherent motion (IVIM) imaging.
Anna Lebret, Simon Lévy, Nikolai Pfender, Mazda Farshad, Franziska C. S. Altorfer, Virginie Callot, Armin Curt, Patrick Freund, Maryam Seif   +8 more
doaj   +1 more source

Origins of Neural Progenitor Cell-Derived Axons Projecting Caudally after Spinal Cord Injury. [PDF]

, 2019
Neural progenitor cells (NPCs) transplanted into sites of spinal cord injury (SCI) extend large numbers of axons into the caudal host spinal cord. We determined the precise locations of neurons in the graft that extend axons into the caudal host spinal ...
Anil, Selin, Dobkins, Gabriel, Ferguson, Adam R, Gomes-Leal, Walace, Graham, Lori, Huie, J Russell, Lu, Paul, Tuszynski, Mark   +7 more
core   +1 more source