Results 41 to 50 of about 222,712 (316)

Trainer in a pocket - proof-of-concept of mobile, real-time, foot kinematics feedback for gait pattern normalization in individuals after stroke, incomplete spinal cord injury and elderly patients

Journal of NeuroEngineering and Rehabilitation, 2018
Background Walking disabilities negatively affect inclusion in society and quality of life and increase the risk for secondary complications. It has been shown that external feedback applied by therapists and/or robotic training devices enables ...
Daniel Schließmann, Maria Nisser, Christian Schuld, Till Gladow, Steffen Derlien, Laura Heutehaus, Norbert Weidner, Ulrich Smolenski, Rüdiger Rupp   +8 more
doaj   +1 more source

A Sonomyography-based Muscle Computer Interface for Individuals with Spinal Cord Injury [PDF]

arXiv, 2023
Impairment of hand functions in individuals with spinal cord injury (SCI) severely disrupts activities of daily living. Recent advances have enabled rehabilitation assisted by robotic devices to augment the residual function of the muscles. Traditionally, non-invasive electromyography-based peripheral neural interfaces have been utilized to sense ...
arxiv  

SARS‐CoV‐2 Is Linked to Brain Volume Loss in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The impact of SARS‐CoV‐2 infection on brain and spinal cord pathology in patients with multiple sclerosis (pwMS) remains unclear. We aimed to describe changes in brain lesion activity and brain and spinal cord volumes following SARS‐CoV‐2 infection.
Tomas Uher, Dominika Stastna, Ingrid Menkyova, Vaclav Capek, Jiri Lindner, Petra Nytrova, Jan Krasensky, Eliza Varju, Miguel D'haeseleer, Eva Kubala Havrdova, Dana Horakova, Manuela Vaneckova, Niels Bergsland   +12 more
wiley   +1 more source

Reliability of patient-specific gait profiles with inertial measurement units during the 2-min walk test in incomplete spinal cord injury

Scientific Reports
Most established clinical walking tests assess specific aspects of movement function (velocity, endurance, etc.) but are generally unable to determine specific biomechanical or neurological deficits that limit an individual’s ability to walk.
Romina Willi, Charlotte Werner, László Demkó, Rob de Bie, Linard Filli, Björn Zörner, Armin Curt, Marc Bolliger   +7 more
doaj   +1 more source

Delayed administration of nafamostat mesylate inhibits thrombin-mediated blood–spinal cord barrier breakdown during acute spinal cord injury in rats

Journal of Neuroinflammation, 2022
Background Nafamostat mesylate (nafamostat, NM) is an FDA-approved serine protease inhibitor that exerts anti-neuroinflammation and neuroprotective effects following rat spinal cord injury (SCI).
Chenxi Zhao, Tiangang Zhou, Xiaoqing Zhao, Yilin Pang, Wenxiang Li, Baoyou Fan, Ming Li, Xinjie Liu, Lei Ma, Jiawei Zhang, Chao Sun, Wenyuan Shen, Xiaohong Kong, Xue Yao, Shiqing Feng   +14 more
doaj   +1 more source

Correlation Analysis Between Magnetic Resonance Imaging-Based Anatomical Assessment and Behavioral Outcome in a Rat Contusion Model of Chronic Thoracic Spinal Cord Injury

Frontiers in Neuroscience, 2022
Although plenty of evidences from preclinical studies have led to potential treatments for patients with spinal cord injury (SCI), the failure to translate promising preclinical findings into clinical advances has long puzzled researchers.
Cong Xing, Cong Xing, Cong Xing, Zeyu Jia, Zeyu Jia, Zeyu Jia, Haodong Qu, Haodong Qu, Haodong Qu, Song Liu, Song Liu, Song Liu, Wang Jiang, Hao Zhong, Hao Zhong, Hao Zhong, Mi Zhou, Mi Zhou, Mi Zhou, Shibo Zhu, Shibo Zhu, Shibo Zhu, Guangzhi Ning, Guangzhi Ning, Guangzhi Ning, Shiqing Feng, Shiqing Feng, Shiqing Feng   +27 more
doaj   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

International surveillance study in acute spinal cord injury confirms viability of multinational clinical trials

BMC Medicine, 2022
Background The epidemiological international landscape of traumatic spinal cord injury (SCI) has evolved over the last decades along with given inherent differences in acute care and rehabilitation across countries and jurisdictions.
Lucie Bourguignon, Bobo Tong, Fred Geisler, Martin Schubert, Frank Röhrich, Marion Saur, Norbert Weidner, Rüdiger Rupp, Yorck-Bernhard B. Kalke, Rainer Abel, Doris Maier, Lukas Grassner, Harvinder S. Chhabra, Thomas Liebscher, Jacquelyn J. Cragg, EMSCI study group, John Kramer, Armin Curt, Catherine R. Jutzeler   +18 more
doaj   +1 more source

Spinal Cord Epidural Stimulation Improves Lower Spine Sitting Posture Following Severe Cervical Spinal Cord Injury

Bioengineering, 2023
Cervical spinal cord injury (SCI) leads to impaired trunk motor control, negatively impacting the performance of activities of daily living in the affected individuals.
Kundan Joshi, Enrico Rejc, Beatrice Ugiliweneza, Susan J. Harkema, Claudia A. Angeli   +4 more
doaj   +1 more source

Controlled Release of Human Dental Pulp Stem Cell‐Derived Exosomes from Hydrogels Attenuates Temporomandibular Joint Osteoarthritis

Advanced Healthcare Materials, EarlyView.
Exosomes can reduce tissue damage in temporomandibular joint osteoarthritis (TMJOA), but rapid clearance limits their efficacy. This study encapsulates exosomes in hyaluronic acid hydrogels for controlled release. In a rat model, hydrogel‐encapsulated exosomes outperform free exosomes in preserving bone integrity and reducing tissue destruction ...
Victor Diez‐Guardia, Yajing Tian, Yunzhe Guo, Jiaying Li, Shengjie Cui, Cécile A. Dreiss, Eileen Gentleman, Xuedong Wang   +7 more
wiley   +1 more source