Results 41 to 50 of about 670,877 (408)

Unresolved excess accumulation of myelin-derived cholesterol contributes to scar formation after spinal cord injury [PDF]

arXiv, 2022
Background: Spinal cord injury triggers complex pathological cascades, resulting in destructive tissue damage and incomplete tissue repair. Scar formation is generally considered as a barrier for regeneration in central nervous system (CNS), while the intrinsic mechanism of scar-forming after spinal cord injury has not been completed deciphered ...
arxiv  

The Biology of Regeneration Failure and Success After Spinal Cord Injury.

Physiological Reviews, 2018
Since no approved therapies to restore mobility and sensation following spinal cord injury (SCI) currently exist, a better understanding of the cellular and molecular mechanisms following SCI that compromise regeneration or neuroplasticity is needed to ...
A. Tran, P. Warren, J. Silver
semanticscholar   +1 more source

Ulnar nerve integrity predicts 1-year outcome in cervical spinal cord injury

Neurological Research and Practice, 2019
Background Accurate predictors of neurological recovery after cervical spinal cord injury are needed. Particularly, to tailor adequate rehabilitation plans. However, objective and quantifiable predictors are sparse.
Andreas Hug, Christian Schuld, Bettina Mürle, Markus Böttinger, EMSCI study group, Norbert Weidner, Rüdiger Rupp   +6 more
doaj   +1 more source

Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury

Nature Communications, 2019
The role of microglia in spinal cord injury (SCI) remains poorly understood and is often confused with the response of macrophages. Here, we use specific transgenic mouse lines and depleting agents to understand the response of microglia after SCI.
V. Bellver-Landete, Floriane Bretheau, Benoit Mailhot, Nicolas Vallières, Martine Lessard, Marie-Ève Janelle, N. Vernoux, M. Tremblay, Tobias Fuehrmann, M. Shoichet, S. Lacroix   +10 more
semanticscholar   +1 more source

The Animal Model of Spinal Cord Injury as an Experimental Pain Model [PDF]

, 2011
Pain, which remains largely unsolved, is one of the most crucial problems for spinal cord injury patients. Due to sensory problems, as well as motor dysfunctions, spinal cord injury research has proven to be complex and difficult. Furthermore, many types
Hosokawa, Ko, Mashimo, Takashi, Nakae, Aya, Nakai, Kunihiro, Shibata, Masahiko, Yano, Kenji   +5 more
core   +3 more sources

Mediolateral damping of an overhead body weight support system assists stability during treadmill walking

Journal of NeuroEngineering and Rehabilitation, 2020
Background Body weight support systems with three or more degrees of freedom (3-DoF) are permissive and safe environments that provide unloading and allow unrestricted movement in any direction.
M. Bannwart, S. L. Bayer, N. König Ignasiak, M. Bolliger, G. Rauter, C. A. Easthope   +5 more
doaj   +1 more source

The patient-related factors in revision procedures on tibia of patients with osteogenesis imperfecta treated with the Peter-Williams nail

Journal of Orthopaedic Surgery and Research, 2023
Objective To investigate the patient-related factors that affect the revision rate for the tibia in patients with osteogenesis imperfecta treated with the Peter-Williams nail, and to explore the relationship between the risk factors and complications ...
Wenbiao Zhu, Yang Xiong, Bo Li, Hongjiang Yang, Cong Xing, Xiuzhi Ren, Guangzhi Ning   +6 more
doaj   +1 more source

Delayed microglial depletion after spinal cord injury reduces chronic inflammation and neurodegeneration in the brain and improves neurological recovery in male mice

Theranostics, 2020
Neuropsychological deficits, including impairments in learning and memory, occur after spinal cord injury (SCI). In experimental SCI models, we and others have reported that such changes reflect sustained microglia activation in the brain that is ...
Yun Li, Rodney M. Ritzel, Niaz Z. Khan, T. Cao, Junyun He, Zhuofan Lei, Jessica J. Matyas, B. Sabirzhanov, Simon Liu, Hui Li, B. Stoica, David J. Loane, A. Faden, Junfang Wu   +13 more
semanticscholar   +1 more source

Beyond treatment of chronic pain: a scoping review about epidural electrical spinal cord stimulation to restore sensorimotor and autonomic function after spinal cord injury

Neurological Research and Practice, 2023
Epidural electrical epinal cord stimulation (ESCS) is an established therapeutic option in various chronic pain conditions. In the last decade, proof-of-concept studies have demonstrated that ESCS in combination with task-oriented rehabilitative ...
Antonia Luz, Rüdiger Rupp, Rezvan Ahmadi, Norbert Weidner   +3 more
doaj   +1 more source

Reviving the use of inhibitors of matrix metalloproteases in spinal cord injury:a case for specificity [PDF]

, 2023
At present, there are no restorative therapies in the clinic for spinal cord injury, with current treatments offering only palliative treatment options.
Ahmed, Zubair
core   +1 more source