Results 81 to 90 of about 296,292 (322)
Suicide Gene Therapy By Amphiphilic Copolymer Nanocarrier for Spinal Cord Tumor
Nanomaterials, 2019 Spinal cord tumors (SCT) are uncommon neoplasms characterized by irregular growth of tissue inside the spinal cord that can result in non-mechanical back pain.
So-Jung Gwak, J. Lee
semanticscholar +1 more source
Advanced Science, EarlyView.This study combined microscale 3D‐printing with 2D Ti3C2Tx MXene nanosheets to produce electroconductive microfibrous micro‐meshes. By embedding these MXene‐functionalized micro‐meshes within a growth‐supportive macroporous extracellular matrix (ECM)‐based biomaterial, multifunctional biomimetic MXene‐ECM scaffolds were developed.
Ian Woods +10 more
wiley +1 more source
Integrated ‘Shield‐Spear’ Biological Patch for Fibrosis‐Free Bladder Reconstruction
Advanced Science, EarlyView.Fibrosis‐free bladder reconstruction remains challenging. This study pioneers an integrated “shield‐spear” patch: The outer anionic hydrogel layer captures GATA6+ macrophages to suppress collagen overexpression, while the inner S100 aptamer‐engineered EVs target Schwann cells to downregulate the TGFβ/Smad pathway—inhibiting fibrosis with enhanced wound
Xiaoqi Wu +14 more
wiley +1 more source
Advanced Science, EarlyView.The study in this paper found that activating the α2A receptors of astrocytes in the thoracic spinal cord can reduce the release of inflammatory factors, thereby decreasing the necroptosis of GABAergic neurons and consequently alleviating myocardial injury caused by sepsis.
Ruilin He +9 more
wiley +1 more source
Bioprinted Organoids: An Innovative Engine in Biomedicine
Advanced Science, EarlyView.Bioprinted organoids refer to either the printing of stem cells into tissue shape and subsequent differentiate into organoids, or assembling induced organoids as bioinks to replicate native organ. It enables the creation of miniaturized organs with complex architectures and physiological functions, potentially enhancing reproducibility, throughput, and
Zhengwei Li +11 more
wiley +1 more source
Treatment of primary glial neoplasms of the spinal cord in children: Twenty years of experience from the Childrens Hospital of Philadelphia (CHOP) [PDF]
, 2004 Thomas J. Dilling +9 more
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Advanced Science, EarlyView.This study systematically explores the action mechanism of Pon3 and its regulatory targets in spinal cord injury (SCI). It demonstrates that Dnmt1 regulates Pon3 expression by modulating methylation levels, thereby inhibiting S1PR1‐mediated pyroptosis and improving SCI prognosis.
Birong Peng +8 more
wiley +1 more source
Advanced Science, EarlyView.LSMEM1, an evolutionarily conserved micropeptide with extreme hydrophobicity (aliphatic index═113) and dynamic amphiphilicity (GRAVY═0.017), features a strong α‐helical transmembrane anchor (residues 64‐86). Single‐cell analysis reveals its critical role in renal lipid homeostasis.
Peimin Liu +11 more
wiley +1 more source
Advanced Science, EarlyView.This schematic representation illustrates the interaction mechanisms between polyphenolic compounds and various materials (metals, proteins, polysaccharides, alkaloids, etc.). And explains the potential clinical application value of these materials (nanoparticles, coatings, films, capsules, and hydrogels constructed using polyphenols) in the fields of ...
Songwen Xue +6 more
wiley +1 more source