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Closed-Loop Spinal Cord Stimulation in Chronic Pain Management: Mechanisms, Clinical Evidence, and Emerging Perspectives [PDF]

Biomedicines
Background: Chronic pain remains a major clinical challenge, which is often resistant to conventional treatments. Spinal cord stimulation has been used for decades to manage refractory pain, traditionally relying on open-loop systems with fixed-output ...
Nicholas Mangano, Andrew Torpey, Catherine Devitt, George A. Wen, Christopher Doh, Abhishek Gupta   +5 more
doaj   +2 more sources

Comparison of the Interference Effects on Somatosensory Evoked Potential from Tonic, Burst, and High-dose Spinal Cord Stimulations

Neurologia Medico-Chirurgica, 2022
Spinal cord stimulations have been used widely to treat intractable neuropathic pain. The conventional spinal cord stimulation paradigm, the “tonic” type, suppresses excessive activation of wide dynamic range neurons in the dorsal horn via the collateral
Eiichirou URASAKI, Yasushi MIYAGI, Shogo MURAMATSU, Yasutaka EZAKI   +3 more
doaj   +1 more source

Epidural electrical stimulation for spinal cord injury

Neural Regeneration Research, 2021
A long-standing goal of spinal cord injury research is to develop effective repair strategies, which can restore motor and sensory functions to near-normal levels.
Elliot H Choi, Sandra Gattas, Nolan J Brown, John D Hong, Joshua N Limbo, Alvin Y Chan, Michael Y Oh   +6 more
doaj   +1 more source

A Fully Implantable Miniaturized Liquid Crystal Polymer (LCP)-Based Spinal Cord Stimulator for Pain Control

Sensors, 2022
Spinal cord stimulation is a therapy to treat the severe neuropathic pain by suppressing the pain signal via electrical stimulation of the spinal cord.
Seunghyeon Yun, Chin Su Koh, Jungmin Seo, Shinyong Shim, Minkyung Park, Hyun Ho Jung, Kyungsik Eom, Jin Woo Chang, Sung June Kim   +8 more
doaj   +1 more source

Complex Electrical Stimulation Systems in Motor Function Rehabilitation after Spinal Cord Injury

Complexity, 2021
Spinal cord injury (SCI) is an existing incurable disease that brings great pain and life obstacles to patients. Spinal cord electrical stimulation is an effective means to alleviate spinal cord injury.
Jiange Kou, Maolin Cai, Fei Xie, Yixuan Wang, Na Wang, Meng Xu   +5 more
doaj   +1 more source

Mesenchymal stem cells, extracellular vesicles, and transcranial magnetic stimulation for ferroptosis after spinal cord injury

Neural Regeneration Research, 2023
Spinal cord injury is characterized by different aetiologies, complex pathogenesis, and diverse pathological changes. Current treatments are not ideal, and prognosis is generally poor.
Qi-Feng Song, Qian Cui, Ya-Shi Wang, Li-Xin Zhang   +3 more
doaj   +1 more source

Nerve root magnetic stimulation improves locomotor function following spinal cord injury with electrophysiological improvements and cortical synaptic reconstruction

Neural Regeneration Research, 2022
Following a spinal cord injury, there are usually a number of neural pathways that remain intact in the spinal cord. These residual nerve fibers are important, as they could be used to reconstruct the neural circuits that enable motor function. Our group
Ya Zheng, Dan Zhao, Dong-Dong Xue, Ye-Ran Mao, Ling-Yun Cao, Ye Zhang, Guang-Yue Zhu, Qi Yang, Dong-Sheng Xu   +8 more
doaj   +1 more source

Epidural electrical stimulation effectively restores locomotion function in rats with complete spinal cord injury

Neural Regeneration Research, 2021
Epidural electrical stimulation can restore limb motor function after spinal cord injury by reactivating the surviving neural circuits. In previous epidural electrical stimulation studies, single electrode sites and continuous tetanic stimulation have ...
Song Wang, Li-Cheng Zhang, Hai-Tao Fu, Jun-Hao Deng, Gao-Xiang Xu, Tong Li, Xin-Ran Ji, Pei-Fu Tang   +7 more
doaj   +1 more source

A flexible electrode array for determining regions of motor function activated by epidural spinal cord stimulation in rats with spinal cord injury

Neural Regeneration Research, 2022
Epidural stimulation of the spinal cord is a promising technique for the recovery of motor function after spinal cord injury. The key challenges within the reconstruction of motor function for paralyzed limbs are the precise control of sites and ...
Guang-Wei Mao, Jian-Jun Zhang, Hao Su, Zhi-Jun Zhou, Lin-Sen Zhu, Xiao-Ying Lü, Zhi-Gong Wang   +6 more
doaj   +1 more source

Changes in spinal cord hemodynamics reflect modulation of spinal network with different parameters of epidural stimulation

NeuroImage, 2020
In this study functional ultrasound (fUS) imaging has been implemented to explore the local hemodynamics response induced by electrical epidural stimulation and to study real-time in vivo functional changes of the spinal cord, taking advantage of the ...
Shanshan Tang, Carlos A. Cuellar, Pengfei Song, Riazul Islam, Chengwu Huang, Hai Wen, Bruce E. Knudsen, Ping Gong, U-Wai Lok, Shigao Chen, Igor A. Lavrov   +10 more
doaj   +1 more source