The Locus Coeruleus‐Periaqueductal Gray GABAergic Projection Regulates Comorbid Pain and Depression
Advanced Science, EarlyView.LC‐GABA neurons exhibit elevated activity to noxious and aversive stimuli in chronic pain, and their activation alleviates pain‐ and depression‐like behaviors. While LC‐GABA neurons target LC‐NA neurons and GABA and Glu neurons in the vlPAG, they modulate the pain responses of LC‐NA neurons but regulate pain‐ and depression‐like behaviors through their
Yuan Gao +7 more
wiley +1 more source
The impact of the SARS-CoV-2 pandemic on referral characteristics in a national tertiary spinal injuries unit. [PDF]
Ir J Med Sci, 2022 O'Halloran L +10 more
europepmc +1 more source
Advanced Science, EarlyView.This study develops a cartilage‐targeted DNA origami system (OCS) that protects and delivers si‐Stat3 to chondrocytes. OCS reduces MMP13 expression, enhances extracellular matrix stability, and lowers oxidative stress while improving cell survival. In vivo, OCS decreases cartilage degradation biomarkers and promotes tissue repair factors, demonstrating
Qi Lv +8 more
wiley +1 more source
Diagnostic Value of Magnetic Resonance Imaging Scan, Multislice Spiral Computed Tomography Three-Dimensional Reconstruction Combined with Plain Film X-Ray in Spinal Injuries. [PDF]
Contrast Media Mol Imaging, 2022 Xin D, Lei L.
europepmc +1 more source
Delayed Transplantation of Neural Stem Cells Improves Initial Graft Survival after Stroke
Advanced Science, EarlyView.Delayed transplantation of human iPSC‐derived neural progenitor cells (NPCs) enhances graft survival, proliferation, and axonal sprouting after stroke. Using bioluminescence imaging and histology in a mouse model of stroke, it is shown that NPC delivery at 7 days post‐stroke is more effective than acute transplantation, highlighting the importance of ...
Rebecca Z Weber +6 more
wiley +1 more source
Predictive ability of frailty scores in surgically managed patients with traumatic spinal injuries: a TQIP analysis. [PDF]
Eur J Trauma Emerg SurgForssten MP +6 more
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The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis
Advanced Science, EarlyView.This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen +6 more
wiley +1 more source
Improving the rehabilitation of individuals admitted to England's National Spinal Injuries Centre with traumatic brain injury. [PDF]
Spinal Cord Ser CasesFalshaw L, King N, Cotter I.
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Incidence and characteristics of spinal injuries in the victims of intimate partner violence (IPV). [PDF]
Emerg Radiol, 2021 Watane GV +6 more
europepmc +1 more source
Advanced Science, EarlyView.Compared with those on the pTi surface, macrophages on the TNTs surface present reduced myosin II contractility, which facilitates the nuclear translocation of the UTX. This reduction decreases the enrichment of the repressive H3K27me3 histone modification at the Abca1 gene locus, which promotes the transcription and protein expression of ABCA1 ...
Hengji Jia +8 more
wiley +1 more source