Results 141 to 150 of about 236,106 (298)

Confirmation of suboptimal protocols in spinal immobilisation? [PDF]

, 2015
Cummins, Niamh M, Dixon, Mark, Hannigan, Ailish, Keenan, Scott, O'Halloran, Joseph   +4 more
core   +2 more sources

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Trampoline-Associated Cranial and Spinal Injuries: A 10-Year Study in a Pediatric Neurosurgery Center. [PDF]

Cureus, 2023
Das JM, Baig A, Togarepi N, Soon WC, Gallo P, Walsh AR, Solanki GA, Rodrigues D, Lo WB.   +8 more
europepmc   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Integrated spine trauma team protocol: Combined neurosurgical and orthopedic experience for the management of traumatic spinal injuries. [PDF]

J Neurosci Rural Pract, 2023
Giorgi PD, Villa FG, Cenzato M, Capitani D, Antonio DG, Legrenzi S, Puglia F, Picano M, Boeris D, Debernardi A, Schirò GR.   +10 more
europepmc   +1 more source

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

Proprioceptive feedback amplification restores effective locomotion in a neuromechanical model of lampreys with spinal injuries. [PDF]

Proc Natl Acad Sci U S A, 2023
Hamlet C, Fauci L, Morgan JR, Tytell ED.
europepmc   +1 more source

Targeted H2S Delivery System Attenuates Blood‐Spinal Cord Barrier Disruption after Spinal Cord Injury by Reshaping the Ferritinophagy Pathway

Advanced Science, EarlyView.
The αvβ3‐mediated SPRC@MPDA‐RGD targets broken endothelial cells and controllably releases SPRC. CSE is then activated to produce endogenous H2S, which inhibits ferritinophagy. In brief, H2S inhibits autophagy by activating the PI3K/Akt/mTOR pathway, thereby suppressing the ferroptosis process mediated by NCOA4, and ultimately promoting the ...
Zhiheng Chen, Xinkai Pu, Ruiyang Li, Yuezhou Wu, Qirong Zhou, Jian Wang, Yuxuan Qian, Fengjie Lu, Jian‐Yuan Zhao, Zhida Su, Jiacan Su, Xiaofeng Lian   +11 more
wiley   +1 more source

The Cyclophosphamide Story: From Killer Gas to Life-saving Drug for Cancers and Inflammatory Rheumatic and Musculoskeletal Diseases (I-RMDs)

Indian Journal of Rheumatology
Cyclophosphamide (CYC), a derivative of mustard gas, has been a cornerstone in treating life-threatening complications of various inflammatory rheumatic and musculoskeletal diseases (I-RMDs) since the mid-twentieth century, despite its well-documented ...
Niti Yash Kedia, Anand N. Malaviya
doaj   +1 more source

Falls on an inpatient rehabilitation spinal injuries unit: the characteristics, circumstances, and consequences. [PDF]

Spinal Cord, 2023
Marshall K, Fleming J, Atresh S, Scott JR, Gustafsson L, Patterson F.   +5 more
europepmc   +1 more source