Results 111 to 120 of about 888,799 (202)

Forced oscillation technique in spinal muscular atrophy

, 2022
BACKGROUND: Spinal muscular atrophy (SMA) causes respiratory compromise that is difficult to assess in young children. The forced oscillation technique (FOT) is commercially available for children as young as 2 years of age and is nonvolitional.
L A Keeling (13374360), Peter Sly (13095165), L M Gauld (13374357), C E Shackleton (13374363)   +3 more
core  

Spinal bracing and lung function in type-2 spinal muscular atrophy [PDF]

, 2019
Respiratory muscle weakness associated with scoliosis in type-2 spinal muscular atrophy (SMA) leads to respiratory impairment. Spinal brace, generally utilized to slow scoliosis progression and support sitting, could worsen lung function and hamper cough
Benini, Franca, Di Pede, Chiara, MOTTA, MATTEO, Ferrari, Adriano, Agosto, Caterina, Salamon, Eleonora   +5 more
core   +1 more source

Addressing Missing Data in Clinical Trials With a Hybrid Control Arm

Statistics in Medicine, Volume 45, Issue 25-27, November 2026.
ABSTRACT Randomized trials have long been the standard for evaluating experimental treatments in medical and pharmacological studies, but the associated time and cost have spurred research into designs that augment randomized studies with data from external sources.
Joshua Wasserman, Herbert Pang, Jiawen Zhu   +2 more
wiley   +1 more source

Forced oscillation technique in spinal muscular atrophy

, 2014
BACKGROUND: Spinal muscular atrophy (SMA) causes respiratory compromise that is difficult to assess in young children. The forced oscillation technique (FOT) is commercially available for children as young as 2 years of age and is nonvolitional.
Sly, P.D., Gauld, L.M., Keeling, L.A., Shackleton, C.E.   +3 more
core   +1 more source

Initial Review of Government‐Funded Reproductive Carrier Screening for Cystic Fibrosis, Spinal Muscular Atrophy and Fragile X Syndrome

Prenatal Diagnosis, EarlyView.
Paul A. Scuffham, Edwin P. Kirk, Martin B. Delatycki, Martin Downes, Nigel G. Laing   +4 more
wiley   +1 more source

Intrahousehold aggression in two dogs with pain experience as the primary motivational factor of the dogs’ aggressive behaviours

Veterinary Record Case Reports, Volume 14, Issue 4, November 2026.
Abstract We present two cases of intrahousehold aggression in dogs experiencing undiagnosed physical discomfort, including pain. Pain was expected to be a motivational factor, as a physical issue marked the start of the aggression and as not all stimuli were related to the dogs’ direct external environment, pointing at possible internal stimuli. Victim‐
I. R. van Herwijnen, S. M. A. Gardeweg, C. M. Vinke, P. Schulte, D. Hartman   +4 more
wiley   +1 more source

Outcomes of children and young people with cerebral palsy receiving long‐term respiratory support: A systematic review

Developmental Medicine &Child Neurology, Volume 68, Issue 11, Page 1514-1524, November 2026.
Outcomes of children with cerebral palsy receiving long‐term respiratory support. This systematic review is commented by Cooper on pages 1492–1493 of this issue. Abstract Aim To systematically review the current knowledge gap in, and impact of, long‐term respiratory support in children and young people (CYP) with cerebral palsy (CP). Method We searched
Rajkumar Dhandayuthapani, Alasdair Campbell, Catherine M McDougall, Florian Gahleitner, Steve Cunningham, Don S Urquhart   +5 more
wiley   +1 more source

Rapid Access to Photoswitchable RNA Binders: Fluorination Enhances Protein Rescue by Exon Inclusion

Chemistry – A European Journal, Volume 32, Issue 39, 22 October 2026.
An adaptable approach, many light‐switchable RNA binders. We report a versatile strategy for rapidly synthesizing photoswitchable RNA binders. The ligands can target SMN2 pre‐mRNA, restoring the levels of the corresponding protein by exon‐inclusion rescue.
Lei Zhang, Nemanja Djokovic, Alexander Herr, Anna Wacker, Emily Swanson Hay, Daniel Santana, Amanda E. Hargrove, Harald Schwalbe, Katarina Nikolic, Frank Abendroth, Olalla Vázquez   +10 more
wiley   +1 more source

Measuring Fatigue and Fatigability in Spinal Muscular Atrophy (SMA): Challenges and Opportunities. [PDF]

J Clin Med, 2023
Rodriguez-Torres RS, Uher D, Gay EL, Coratti G, Dunaway Young S, Rohwer A, Muni Lofra R, De Vivo DC, Hirano M, Glynn NW, Montes J.   +10 more
europepmc   +1 more source

Bottom‐Up Engineering of a Human Neuromuscular System for Modeling Activity‐Induced Remodeling, Metabolic Stress, and Endothelial‐Modulated Excitability

Advanced Materials, Volume 38, Issue 60, 27 October 2026.
Using a bottom‐up approach, we engineered a human neuromuscular microchip to investigate distinct adaptive responses to neural stimulation and metabolic stress. Further integration of endothelial cells revealed their critical role in modulating neuromuscular excitability, establishing a comprehensive neurovascular‐muscular model.
Jinchul Ahn, Min‐seop Kim, Ju‐Hee Kim, Seok‐Hyeon Kang, Dain Lee, Hui‐Wen Liu, Seung‐cheol Shin, Kyuhwan Na, Yesl Jun, Oak‐Kee Hong, Ji Hun Yang, Jin‐A Kim, Hwanseok Jang, Hong Nam Kim, Roger D. Kamm, Ji‐Hoon Kim, Jang‐Won Son, Seok Chung   +17 more
wiley   +1 more source