Results 121 to 130 of about 888,799 (202)

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, Volume 13, Issue 58, 19 October 2026.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Correlation of Survival Motor Neuron Expression in Leukocytes and Spinal Cord in Spinal Muscular Atrophy

, 2011
Survival motor neuron (SMN) messenger RNA and protein levels in spinal muscular atrophy (SMA) model mice and in patients with SMA were measured. There was a high correlation between leukocyte and spinal cord SMN expression in SMA model mice and a ...
蔡力凱;楊智超;丁振紘;蘇怡寧;胡務亮;李鴻, TSAI, LI-KAI;YANG, CHIH-CHAO;TING, CHEN-HON;SU, YI-NING;HWU, WUH-LIANG;LI, HUNG   +1 more
core   +1 more source

Investigation of cerebellar pathology in mouse models for amyotrophic lateral sclerosis and spinal muscular atrophy [PDF]

The cerebellum was investigated in different mouse models for neurodegenerative diseases Amyotrophic Lateral Sclerosis (ALS) and Spinal Muscular Atrophy (SMA).
Menedo, Christian
core   +3 more sources

Cognitive impairment in children with 5q-associated spinal muscular atrophy type 1: two case reports and the review of the literature

Frontiers in Pediatrics
Spinal muscular atrophy (SMA) is an autosomal recessive disease caused by mutations in the survival motor neuron 1 (SMN1) gene on chromosome 5, leading to the degeneration of lower motor neurons.
Hua Yang, Hua Yang, Jie Yang, Jie Yang, Yawen Xue, Lihui Liao, Qianyun Cai, Qianyun Cai, Rong Luo, Rong Luo   +9 more
doaj   +1 more source

Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation

Advanced Science, Volume 13, Issue 60, 28 October 2026.
Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang, Wenhui Xie, Lei Yang, Zhengrong Wang, Yi Huang, Peng Huang, Yuan Liu, Jun Hu   +7 more
wiley   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Development and Translation of Therapies for Spinal Muscular Atrophy [PDF]

, 2016
Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder characterised by widespread loss of lower motor neurons from the spinal cord, leading to progressive weakness and muscle atrophy.
Shorrock, Hannah K., Gillingwater, Thomas, Thomas H. Gillingwater, Hannah K. Shorrock   +3 more
core   +1 more source

Assessing the Assisted Six-Minute Cycling Test as a Measure of Endurance in Non-Ambulatory Patients with Spinal Muscular Atrophy (SMA). [PDF]

J Clin Med, 2023
Tang WJ, Gu B, Montalvo S, Dunaway Young S, Parker DM, de Monts C, Ataide P, Ni Ghiollagain N, Wheeler MT, Tesi Rocha C, Christle JW, He Z, Day JW, Duong T.   +13 more
europepmc   +1 more source

Botanical, Phytochemistry, Pharmacology and Applications of Genus Heracleum: A Review

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
This manuscript presents a comprehensive review of plant species in the genus Heracleum, from botanical classification and distribution to medicinal uses, phytochemistry, pharmacology, and applications, aiming to provide references for further exploration of their therapeutic value and research development.
Nan Zhang, Yuan Li, Zhi‐Yuan Guo, Ye‐Zi Ma, Miao‐Miao Xu, Dong‐Dong Zhang   +5 more
wiley   +1 more source

Emerging Gene Therapy Approaches in the Management of Spinal Muscular Atrophy (SMA): An Overview of Clinical Trials and Patent Landscape. [PDF]

Int J Mol Sci, 2023
Ponomarev AS, Chulpanova DS, Yanygina LM, Solovyeva VV, Rizvanov AA.   +4 more
europepmc   +1 more source