Results 111 to 120 of about 1,760,803 (361)

Construction of a nomogram prediction model for the influencing factors for spinal nerve injury in elderly parturients after intraspinal block [PDF]

精准医学杂志
Objective To establish a nomogram model for predicting the influence factors for spinal nerve injury in elderly parturients after intraspinal block. Methods A total of 480 elderly parturients who received intraspinal block for delivery in our hospital ...
SHI Yu, YUE Xiuqin, WANG Zhen
doaj   +1 more source

Toll-like Receptor 2 Mediates Peripheral Nerve Injury-induced NADPH Oxidase 2 Expression in Spinal Cord Microglia*

Journal of Biological Chemistry, 2013
Background: Microglial NADPH oxidase 2 (Nox2) expression is critical for nerve injury-induced spinal cord microglia activation and subsequent pain hypersensitivity.
Hyoungsub Lim, Donghoon Kim, Sung Joong Lee   +2 more
semanticscholar   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

AxonDeepSeg: automatic axon and myelin segmentation from microscopy data using convolutional neural networks [PDF]

, 2017
Segmentation of axon and myelin from microscopy images of the nervous system provides useful quantitative information about the tissue microstructure, such as axon density and myelin thickness. This could be used for instance to document cell morphometry
Antonsanti, Pierre-Louis, Cohen-Adad, Julien, Herman, Victor, Perone, Christian Samuel, Wabartha, Maxime, Zaimi, Aldo   +5 more
core   +3 more sources

Remarkable Recovery After Delayed High‐Dose Methylprednisolone in a Rare Case of Penetrating Spinal Cord Injury

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Traumatic spinal cord injury (TSCI) caused by sharp‐force penetration is exceptionally rare, and the use of high‐dose methylprednisolone (MP) remains highly controversial, especially beyond the conventional 8‐h treatment window. This case report describes a 30‐year‐old male with acute incomplete TSCI following a knife stab wound to the right ...
Honghong Wang, Shuang Liu, Jiale Wang, Kaiyang Xue, Shenwei Li, Zhongheng Du   +5 more
wiley   +1 more source

Mitochondrial superoxide increases excitatory synaptic strength in spinal dorsal horn neurons of neuropathic mice

Molecular Pain, 2018
Reactive oxygen species has been suggested as a key player in neuropathic pain, causing central sensitization by changing synaptic strengths in spinal dorsal horn neurons.
Chilman Bae, Jigong Wang, Hyun Soo Shim, Shao-Jun Tang, Jin Mo Chung, Jun-Ho La   +5 more
doaj   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

CAR T‐Cell Therapy in Neurology: A Scoping Review of Neuro‐Oncology, Autoimmune Diseases & Neurotoxicity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi, Mohammed Dibas, Patricia Tai, Ala Dibas, Osama Souied, Suhair Al‐Ghabeesh   +5 more
wiley   +1 more source

Electrical neurostimulation for chronic pain: on selective relay of sensory neural activities in myelinated nerve fibers [PDF]

, 2015
Chronic pain affects about 100 million adults in the US. Despite their great need, neuropharmacology and neurostimulation therapies for chronic pain have been associated with suboptimal efficacy and limited long-term success, as their mechanisms of ...
Sacré, Pierre, Sarma, Sridevi V., Guan, Yun, Anderson, William S.   +3 more
core   +1 more source

Dynamic Changes in the MicroRNA Expression Profile Reveal Multiple Regulatory Mechanisms in the Spinal Nerve Ligation Model of Neuropathic Pain

PLoS ONE, 2011
Neuropathic pain resulting from nerve lesions or dysfunction represents one of the most challenging neurological diseases to treat. A better understanding of the molecular mechanisms responsible for causing these maladaptive responses can help develop ...
D. von Schack, Michael Agostino, B. Murray, Yizheng Li, P. Reddy, Jin Chen, Sung E. Choe, B. Strassle, Christine Li, B. Bates, Lynn Zhang, Huijuan Hu, S. Kotnis, B. Bingham, W. Liu, G. Whiteside, T. Samad, J. Kennedy, Seena K. Ajit   +18 more
semanticscholar   +1 more source