Results 131 to 140 of about 260,916 (317)

GPR124 Alleviates Blood–Brain Barrier Disruption by Enhancing Microvascular Endothelial Function after Traumatic Brain Injury

Advanced Science, EarlyView.
Our study reveals the protective role of GPR124 in maintaining BBB integrity and promoting neurological recovery following TBI. It makes a significant contribution by uncovering a novel molecular interaction between GPR124 and FGFBP1 and linking this to activation of the Wnt/β‐catenin signaling pathway in vascular repair mechanisms.
Chen Wang, Lin Cai, Qiuyuan Gong, Yang Yang, Yuqing Liang, Xinyu Niu, Lai Wei, Ze Liu, Shengju Wu, Yinghui Men, Yaohui Tang, Jun Ding, Hengli Tian, Hao Chen   +13 more
wiley   +1 more source

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

Treatment of spinal cord injury, by restoration of neuronal networks using a combination of surgery and KCL-286, an orally available retinoic acid receptor β drug

Frontiers in Surgery
The most complicated nerve injuries occur in the spinal nerves. Following traumatic injury at the nerve root attachment to the spinal cord (avulsion), there is degeneration of nerve fibres in the root and spinal cord.
Thomas Carlstedt, Jonathan P. T. Corcoran   +1 more
doaj   +1 more source

Nerve entrapment as a cause of shoulder pain in the spinal cord injured patient

, 2017
INTRODUCTION: Many people with chronic spinal cord injury (SCI) develop shoulder pain, which can adversely impact transfers and independence. Yet effective treatments remain elusive.
Curtin, CM, Hultling, C,, Hagert, E,, Hagert, C-G   +3 more
core   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Functional Magnetic Nerve Stimulation: The development of a method of generation of explosive expiratory flows in the intubated patient through abdominal muscle stimulation. [PDF]

, 2012
Functional Magnetic Nerve Stimulation: The development of a method of generation of explosive expiratory flows in the intubated patient through abdominal muscle stimulation.
Turnbull, David
core  

Peripheral Facial Nerve Axotomy in Mice Causes Sprouting of Motor Axons Into Perineuronal Central White Matter: Time Course and Molecular Characterization

, 2010
Generation of new axonal sprouts plays an important role in neural repair In the current study, we examined the appearance, composition and effects of gene deletions on intrabrainstem sprouts following peripheral facial nerve axotomy Axotomy was followed
Werner, A, Galiano, Mathias, Ruff, Crystal, Mathias Galiano, Werner, A., Gonitel, R, Werner, Alexander, Anderson, P., Raivich, G., Patrick N. Anderson, Prakasham Rumajogee, Pararajasingam, A, Bohatschek, M, Behrens, A, Galiano, M., Cuthill, Dan, Bohatschek, M., Acosta-Saltos, A, Makwana, Milan, Dan Cuthill, Rumajogee, P., Anderson, Patrick N., Wallace, A. S., Ulrike Mayer, Acosta-Saltos, Alejandro, Anderson, PN, Behrens, Axel, Raivich, Gennadij, Pararajasingham, A, Gonitel, R., Anderson, P. N., Rumajogee, Prakasham, Ruff, C., Ruff, C, Rumajogee, P, Wallace, AS, Acosta-Saltos, A., Alejandro Acosta‐Saltos, Marion Bohatschek, Axel Behrens, Makwana, M, Wallace, Adam S., Bohatschek, Marion, Gennadij Raivich, Mayer, U, Mayer, Ulrike, Wallace, A., Alexander Werner, Adam S. Wallace, Pararajasingham, Abirami, Behrens, A., Abirami Pararajasingham, Makwana, M., Cuthill, D., Crystal Ruff, Cuthill, D, Galiano, M, Gonitel, Roman, Roman Gonitel, Mayer, U., Milan Makwana, Pararajasingham, A., Raivich, G   +62 more
core   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Intradural Communication of L3 and L4 Ventral Nerve Rootlets of Spinal Nerves

Siriraj Medical Journal, 2004
Normally, the nerve roots within the dural sec never communicate with one another. Even the fusion of the ventral and dorsal nerve roots to form the spinal nerve occurs outside the dural sac.
Kriengkrai Urusopon, Jantima Roongruangchai, Kajee Pilakasiri   +2 more
doaj  

Relationship between median nerve somatosensory evoked potentials and spinal cord injury levels in patients with quadriplegia

, 2015
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Study design: Cross-sectional study. Objectives: To observe if there is a relationship between the level of injury by the American Spinal Cord Injury Association (ASIA) and cortical ...
Cliquet, A, Gaspar, MIFDS, Lima, VMF, de Abreu, DCC   +3 more
core   +1 more source