Results 31 to 40 of about 1,760,803 (361)

TNF-α Differentially Regulates Synaptic Plasticity in the Hippocampus and Spinal Cord by Microglia-Dependent Mechanisms after Peripheral Nerve Injury

Journal of Neuroscience, 2017
Clinical studies show that chronic pain is accompanied by memory deficits and reduction in hippocampal volume. Experimental studies show that spared nerve injury (SNI) of the sciatic nerve induces long-term potentiation (LTP) at C-fiber synapses in ...
Yong Liu, Li-Jun Zhou, Jun Wang, Dai Li, W. Ren, Jiyun Peng, Xiao Wei, Ting Xu, Wen-Jun Xin, R. Pang, Yongyong Li, Zhi-hai Qin, Madhuvika Murugan, M. Mattson, Long-Jun Wu, Xian-Guo Liu   +15 more
semanticscholar   +1 more source

Toll-like receptor signaling adapter proteins govern spread of neuropathic pain and recovery following nerve injury in male mice. [PDF]

, 2013
BackgroundSpinal Toll-like receptors (TLRs) and signaling intermediaries have been implicated in persistent pain states. We examined the roles of two major TLR signaling pathways and selected TLRs in a mononeuropathic allodynia.MethodsL5 spinal nerve ...
A Ledeboer, AI de la Llave-Rincon, AL Oaklander, AS Jaggi, BJ Marsh, C Erridge, C Fernandez-de-las-Penas, C Fernandez-de-las-Penas, CA Christianson, CC Bowman, CF Kim, CI Svensson, CR Stewart, CS Jack, D Kim, D Kim, F Kozin, F Marchand, FY Tanga, H Cao, H Hacker, H Hashizume, H Tsujino, H Yanai, I Bettoni, J Mika, J Zhang, JA DeLeo, JA Stokes, JA Stokes, Jennifer A Stokes, JL Hylden, JM Chung, Jonathan Cheung, K Hoebe, K Honda, K Hoshino, K Kariko, KA Cavassani, Kelly Eddinger, KH Konopka, L Cao, L Nicotra, L Znaor, LA O’Neill, LA Panagio, LH Guo, M Bsibsi, M Calvo, M Chacur, M Hossaini, M Koltzenburg, M Yamamoto, Maripat Corr, MR Hutchinson, MR Hutchinson, NE Saade, O Adachi, O Saito, O Takeuchi, P Hu, P Hu, Q Xu, Q Zhang, R Wang, RE Sorge, RG Chen, RG Zanon, S Akira, S Akira, S Hosmane, S Lehnardt, S Nadeau, S Pu, S Rivest, S Sakaguchi, SR Chaplan, SW Mitchell, T Kawai, T King, T Liu, T Shichita, T Tanaka, Tony L Yaksh, TW Vanderah, V Huge, V Raghavendra, V Raghavendra, XY Hua, Y Ohmichi, YR Wen   +90 more
core   +1 more source

Analysis of current density and related parameters in spinal cord stimulation [PDF]

, 1998
A volume conductor model of the spinal cord and surrounding anatomical structures is used to calculate current (and current density) charge per pulse, and maximum charge density per pulse at the contact surface of the electrode in the dorsal epidural ...
Boom, Herman B.K., Holsheimer, Jan, Wesselink, Wilbert A.   +2 more
core   +3 more sources

Spinal Microgliosis Due to Resident Microglial Proliferation Is Required for Pain Hypersensitivity after Peripheral Nerve Injury.

Cell Reports, 2016
Peripheral nerve injury causes neuropathic pain accompanied by remarkable microgliosis in the spinal cord dorsal horn. However, it is still debated whether infiltrated monocytes contribute to injury-induced expansion of the microglial population.
N. Gu, Jiyun Peng, Madhuvika Murugan, Xi Wang, Ukpong B. Eyo, Dongming Sun, Yi Ren, E. Dicicco-Bloom, W. Young, Hailong Dong, Long-Jun Wu   +10 more
semanticscholar   +1 more source

The glia response after peripheral nerve injury: A comparison between Schwann cells and olfactory ensheathing cells and their uses for neural regenerative therapies [PDF]

, 2017
The peripheral nervous system (PNS) exhibits a much larger capacity for regeneration than the central nervous system (CNS). One reason for this difference is the difference in glial cell types between the two systems.
Barton, Matthew J., Clarke, Mary, Ekberg, Jenny, St. John, James, Wright, Alison   +4 more
core   +2 more sources

Basic mechanisms of peripheral nerve injury and treatment via electrical stimulation

Neural Regeneration Research, 2022
Previous studies on the mechanisms of peripheral nerve injury (PNI) have mainly focused on the pathophysiological changes within a single injury site. However, recent studies have indicated that within the central nervous system, PNI can lead to changes ...
Xiaolei Chu, Xizi Song, Qi Li, Yu-Ru Li, Feng He, Xiaosong Gu, Dong Ming   +6 more
semanticscholar   +1 more source

Neuronal Control of Swimming Behavior: Comparison of Vertebrate and Invertebrate Model Systems [PDF]

, 2011
Swimming movements in the leech and lamprey are highly analogous, and lack homology. Thus, similarities in mechanisms must arise from convergent evolution rather than from common ancestry.
Buchanan, James T., Friesen, W. Otto, Hackett, John, Mullins, Olivia   +3 more
core   +2 more sources

Bilateral abducens nerve palsy from post-spinal-anesthesia-induced bilateral chronic subdural hematoma: case report

Frontiers in Anesthesiology, 2023
BackgroundA chronic cranial subdural hematoma arising after post-spinal anesthesia is a rare but serious and life-threatening complication of spinal anesthesia. It usually mimics the typical post-spinal-anesthesia headache or post-dural-puncture headache,
Mestet Yibeltal Shiferaw, Tsegazeab Laeke T/Mariam, Abenezer Tirsit Aklilu, Kibruyisfaw Zewudie Shumbash, Yemisirach Bizuneh Akililu, Bethelhem Yishak Worku, Mengistu Ayele   +6 more
doaj   +1 more source

Spinal Cord and Spinal Nerve Root Involvement (Myeloradiculopathy) in Tuberculous Meningitis

Medicine, 2015
Most of the information about spinal cord and nerve root involvement in tuberculous meningitis is available in the form of isolated case reports or case series. In this article, we evaluated the incidence, predictors, and prognostic impact of spinal cord
Rahul Gupta, R. Garg, Amita Jain, H. Malhotra, R. Verma, P. Sharma   +5 more
semanticscholar   +1 more source

Functional, morphological and molecular characteristics in a novel rat model of spinal sacral nerve injury-surgical approach, pathological process and clinical relevance

Scientific Reports, 2022
Spinal sacral nerve injury represents one of the most serious conditions associated with many diseases such as sacral fracture, tethered cord syndrome and sacral canal tumor.
Junyang Li, Shiqiang Li, Yu Wang, Aijia Shang   +3 more
doaj   +1 more source