Results 11 to 20 of about 260,916 (317)

Sciatic Nerve Block Combined with Flurbiprofen Inhibits Spinal Cord Inflammation and Improves Postoperative Pain in Rats with Plantar Incision

Journal of Pain Research, 2023
Meihong Li,1 Kaiwen Zhang,1 Ting Li,2 Yuye Chen,1 Hu Zang,1 Yingjie Hu,1 Wenlong Yao1 1Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Department of Anesthesiology,
Li M, Zhang K, Li T, Chen Y, Zang H, Hu Y, Yao W   +6 more
doaj   +1 more source

Lack of evidence for sprouting of Aβ afferents into the superficial laminas of the spinal cord dorsal horn after nerve section [PDF]

, 2003
The central arborizations of large myelinated cutaneous afferents normally extend as far dorsally as the ventral part of lamina II in rat spinal cord. Woolf et al. (1992) reported that after nerve injury some of these afferents sprouted into lamina I and
Todd, A.J., Riddell, J.S., Dugald T. Scott, John S. Riddell, Andrew J. Todd, Scott, D.T., David I. Hughes, Hughes, D.I.   +7 more
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Upregulation of substance P in low-threshold myelinated afferents is not required for tactile allodynia in the chronic constriction injury and spinal nerve ligation models [PDF]

, 2007
It has been proposed that substance P and calcitonin gene-related peptide (CGRP) are upregulated in low-threshold myelinated primary afferents after certain types of nerve injury, and that release of substance P from these afferents contributes to the ...
Todd, A.J., Riddell, J.S., Scott, D.T., Hughes, D.I.   +3 more
core   +1 more source

Patients having surgery for ulnar nerve compression at the elbow rarely have affection of the spinal nerve root at C8-Th1 levels

Frontiers in Surgery, 2022
Cervical pathology may contribute to residual problems after surgery for ulnar nerve compression. We aimed to evaluate the presence of pathological conditions in spinal cord and cervical spinal nerve roots in patients surgically treated for ulnar nerve ...
Erika Nyman, Erika Nyman, Alice Giöstad, Alice Giöstad, Kasim Abul-Kasim, Lars B. Dahlin, Lars B. Dahlin, Lars B. Dahlin   +7 more
doaj   +1 more source

Loss of neurons from laminas I-III of the spinal dorsal horn is not required for development of tactile allodynia in the spared nerve injury model of neuropathic pain [PDF]

, 2005
It has been proposed that death of inhibitory interneurons in the dorsal horn contributes to the neuropathic pain that follows partial nerve injury. In this study, we have used two approaches to test whether there is neuronal death in the dorsal horn in ...
Polgar, Erika, Todd, A.J., Arham, A.Z., Hughes, D.I.   +3 more
core   +1 more source

Effects of guanidine on synaptic transmission in the spinal cord of the frog [PDF]

, 1977
The effects of guanidine on motoneurons of the isolated frog spinal cord were studied by adding the drug to the solution bathing the cord during intracellular recording. Guanidine (5·10–4 M) did not alter the membrane potential of motoneurons.
Kühnerl, A., Sonnhof, U., Grafe, Peter
core   +1 more source

Nerve root magnetic stimulation improves locomotor function following spinal cord injury with electrophysiological improvements and cortical synaptic reconstruction

Neural Regeneration Research, 2022
Following a spinal cord injury, there are usually a number of neural pathways that remain intact in the spinal cord. These residual nerve fibers are important, as they could be used to reconstruct the neural circuits that enable motor function. Our group
Ya Zheng, Dan Zhao, Dong-Dong Xue, Ye-Ran Mao, Ling-Yun Cao, Ye Zhang, Guang-Yue Zhu, Qi Yang, Dong-Sheng Xu   +8 more
doaj   +1 more source

R-flurbiprofen reduces neuropathic pain in rodents by restoring endogenous cannabinoids [PDF]

, 2010
Background: R-flurbiprofen, one of the enantiomers of flurbiprofen racemate, is inactive with respect to cyclooxygenase inhibition, but shows analgesic properties without relevant toxicity. Its mode of action is still unclear.
Geisslinger, Gerd, Gerd Geisslinger, Ziebell Simone, Julia Metzner, Ziebell, Simone, Koch, Marco, Myrczek, Thekla, Marian, Claudiu, Dehghani, Faramarz, Rohini Kuner, Schmidt Helmut, Bechmann Ingo, Marian Claudiu, Nina Wijnvoord, Dehghani Faramarz, Philipp Bishay, Bishay, Philipp, Kuner, Rohini, Helmut Schmidt, Faramarz Dehghani, Koch Marco, Bechmann, Ingo, Metzner, Julia, Geisslinger Gerd, Irmgard Tegeder, Tegeder Irmgard, Simone Ziebell, Wijnvoord, Nina, Tegeder, Irmgard, Claudiu Marian, Kuner Rohini, Costigan, Michael, Wijnvoord Nina, Annett Häussler, Ingo Bechmann, Michael Costigan, Schmidt, Helmut, Häussler, Annett, Bechmann, Ingo Jürgen, Myrczek Thekla, Bishay Philipp, Häussler Annett, Marco Koch, Costigan Michael, Thekla Myrczek, Metzner Julia   +45 more
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Regulation of nerve growth and patterning by cell surface protein disulphide isomerase

eLife, 2020
Contact repulsion of growing axons is an essential mechanism for spinal nerve patterning. In birds and mammals the embryonic somites generate a linear series of impenetrable barriers, forcing axon growth cones to traverse one half of each somite as they ...
Geoffrey MW Cook, Catia Sousa, Julia Schaeffer, Katherine Wiles, Prem Jareonsettasin, Asanish Kalyanasundaram, Eleanor Walder, Catharina Casper, Serena Patel, Pei Wei Chua, Gioia Riboni-Verri, Mansoor Raza, Nol Swaddiwudhipong, Andrew Hui, Ameer Abdullah, Saj Wajed, Roger J Keynes   +16 more
doaj   +1 more source

Adrenomedullin is an Important Pathological Mediator in Progression of Chronic Neuropathic Pain

Frontiers in Bioscience-Landmark, 2022
Background: The characterization of neuropathic pain is maladaptive plasticity within the nociceptive system. Multiple alterations contribute to complex pain phenotypes. Adrenomedullin (AM) has been documented to be a pain mediator.
Chunmei Wang, Yaping Xue, Qiuhua Lu, Yonghui Shi, Wei Tang, Dongmei Wang   +5 more
doaj   +1 more source