Results 11 to 20 of about 1,760,803 (361)

Identification of novel gene signatures and immune cell infiltration in intervertebral disc degeneration using bioinformatics analysis

Frontiers in Molecular Biosciences, 2023
Background: Intervertebral disc degeneration (IDD) is the leading cause of lower back pain, and an overall understanding of the molecular mechanisms related to IDD is still lacking. The purpose of this study was to explore gene signatures and immune cell
Tao Tang, Tao Tang, Zhongyuan He, Zhongyuan He, Zhengya Zhu, Fuan Wang, Fuan Wang, Hongkun Chen, Fu Zhang, Jiaxiang Zhou, Jianmin Wang, Baoliang Li, Baoliang Li, Xizhe Liu, Zhiyu Zhou, Zhiyu Zhou, Shaoyu Liu, Shaoyu Liu   +17 more
doaj   +1 more source

DLX5 regulates the osteogenic differentiation of spinal ligaments cells derived from ossification of the posterior longitudinal ligament patients via NOTCH signaling

JOR Spine, 2023
Background Ossification of the posterior longitudinal ligaments (OPLL) is common disorder characterized by heterotopic ossification of the spinal ligaments. Mechanical stimulation (MS) plays an important role in OPLL.
Tao Tang, Zhengya Zhu, Zhongyuan He, Fuan Wang, Hongkun Chen, Shengkai Liu, Mingbin Zhan, Jianmin Wang, Wei Tian, Dafu Chen, Xinbao Wu, Xizhe Liu, Zhiyu Zhou, Shaoyu Liu   +13 more
doaj   +1 more source

Identification of immunodiagnostic blood biomarkers associated with spinal cord injury severity

Frontiers in Immunology, 2023
Blood always shows some immune changes after spinal cord injury (SCI), and detection of such changes in blood may be helpful for diagnosis and treatment of SCI.
Jianfeng Li, Jianfeng Li, Xizhe Liu, Jianmin Wang, Jianmin Wang, Fuan Wang, Fuan Wang, Zhengya Zhu, Zhengya Zhu, Tao Tang, Tao Tang, Jun Wang, Jun Wang, Zhiyu Zhou, Zhiyu Zhou, Manman Gao, Manman Gao, Shaoyu Liu, Shaoyu Liu   +18 more
doaj   +1 more source

Intradiscal injection for the management of low back pain

JOR Spine, 2022
Low back pain (LBP) is a common clinical problem and a major cause of physical disability, imposing a prominent socioeconomic burden. Intervertebral disc degeneration (IDD) has been considered the main cause of LBP.
Fu Zhang, Songjuan Wang, Baoliang Li, Wei Tian, Zhiyu Zhou, Shaoyu Liu   +5 more
doaj   +1 more source

Intradural angiomatous meningioma arising from a thoracic nerve root [PDF]

, 2017
BACKGROUND: Spinal intradural meningiomas that arise purely from a nerve root without dural attachments are extremely rare. Spinal meningiomas arise from arachnoidal cap cells in the spinal canal, and growth of these tumors exerts pressure on the spinal ...
Domenicucci, Maurizio, Grazia Elefante, Maria, Missori, Paolo, Palmarini, Valeria, Paolini, Sergio, Scapeccia, Marco   +5 more
core   +1 more source

Interfacing peripheral nerve with macro-sieve electrodes following spinal cord injury [PDF]

, 2017
Macro-sieve electrodes were implanted in the sciatic nerve of five adult male Lewis rats following spinal cord injury to assess the ability of the macro-sieve electrode to interface regenerated peripheral nerve fibers post-spinal cord injury. Each spinal
Birenbaum, Nathan K, MacEwan, Matthew R, Ray, Wilson Z   +2 more
core   +3 more sources

Effect of cyclic mechanical loading on immunoinflammatory microenvironment in biofabricating hydroxyapatite scaffold for bone regeneration

Bioactive Materials, 2021
It has been proven that the mechanical microenvironment can impact the differentiation of mesenchymal stem cells (MSCs). However, the effect of mechanical stimuli in biofabricating hydroxyapatite scaffolds on the inflammatory response of MSCs remains ...
Penghui Zhang, Xizhe Liu, Peng Guo, Xianlong Li, Zhongyuan He, Zhen Li, Martin J. Stoddart, Sibylle Grad, Wei Tian, Dafu Chen, Xuenong Zou, Zhiyu Zhou, Shaoyu Liu   +12 more
doaj   +1 more source

Inter-strain differences of serotonergic inhibitory pain control in inbred mice [PDF]

, 2010
Background: Descending inhibitory pain control contributes to the endogenous defense against chronic pain and involves noradrenergic and serotonergic systems.
Wijnvoord, Nina, Albuquerque, Boris, Häussler, Annett, Myrczek, Thekla, Popp, Laura, Tegeder, Irmgard   +5 more
core   +2 more sources

CXCL12/CXCR4 signaling contributes to neuropathic pain via central sensitization mechanisms in a rat spinal nerve ligation model

CNS Neuroscience & Therapeutics, 2019
Previous studies have demonstrated that the CXCL12/CXCR4 signaling axis is involved in the regulation of neuropathic pain (NP). Here, we performed experiments to test whether the CXCL12/CXCR4 signaling pathway contributes to the pathogenesis of ...
Zhiyuan Liu, Zhi-Wen Song, Shiwu Guo, Junsheng He, Shenglong Wang, Jianguo Zhu, Hui-lin Yang, Jin-Bo Liu   +7 more
semanticscholar   +1 more source

Patients having surgery for ulnar nerve compression at the elbow rarely have affection of the spinal nerve root at C8-Th1 levels

Frontiers in Surgery, 2022
Cervical pathology may contribute to residual problems after surgery for ulnar nerve compression. We aimed to evaluate the presence of pathological conditions in spinal cord and cervical spinal nerve roots in patients surgically treated for ulnar nerve ...
Erika Nyman, Erika Nyman, Alice Giöstad, Alice Giöstad, Kasim Abul-Kasim, Lars B. Dahlin, Lars B. Dahlin, Lars B. Dahlin   +7 more
doaj   +1 more source