Results 41 to 50 of about 51,356 (243)

Managing intrathecal administration of nusinersen in adolescents and adults with 5q-spinal muscular atrophy and previous spinal surgery [PDF]

Arquivos de Neuro-Psiquiatria
Background: Spinal muscular atrophy (SMA) is a neurodegenerative disease of lower motor neurons associated with frequent occurrence of spinal deformity.
Rodrigo de Holanda Mendonça, Hermann dos Santos Fernandes, Rafael Barbéro Schimmelpfeng Pinto, Ciro Matsui Júnior, Graziela Jorge Polido, André Macedo Serafim da Silva, Luis Fernando Grossklauss, Umbertina Conti Reed, Edmar Zanoteli   +8 more
doaj   +2 more sources

Electronic Chip‐Mimetic Medical Implants for Controllable Sonothermal Treatments

Advanced Science, EarlyView.
Inspired by the thermal effect of working electronic chips, which consist of various heterostructures, an sonothermal‐responsive platform has been developed through constructing metal‐semiconductor interface on implants. Biofilm infection and deep vein thrombosis can be successfully treated by controllable ultrasound treatments.
Zhengdong Zhang, Pan Liu, Jie Lei, Shuchang Peng, Qiu Chen, Wei Guan, Yizhou Zhu, Gang Liu, Xiaobo Feng, Cao Yang, Lei Tan   +10 more
wiley   +1 more source

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source

POST DURAL PUNCTURE HEADACHE: A COMPARISON OF MIDLINE AND PARAMEDIAN APPROACH OF SPINAL ANESTHESIA

Pakistan Armed Forces Medical Journal, 2020
Objective: To compare the midline and paramedian approaches of spinal anesthesia in terms of incidence of Post Dural Puncture Headache among patients undergoing surgery. Study Design: Comparative prospective study.
Zeeshan Nasir, Saira Mahboob, Tariq Mehmood, Syed Zaheer Haider   +3 more
doaj   +4 more sources

Intrathecal Catheterization by Epidural Catheter: Management of Accidental Dural Puncture and Prophylaxis of PDPH

Indian Journal of Anaesthesia, 2009
Accidental or inadvertent dural puncture during epidural anaesthesia results in high incidence of post dural puncture headache (PDPH). Spinal or intrathecal catheter in such a situation, provides aconduit for administration of appropriate local ...
Ashok Jadon, Swastika Chakraborty, Neelam Sinha, Rajiv Agrawal   +3 more
doaj  

Ultrasound-assisted technique versus the conventional landmark location method in spinal anesthesia for cesarean delivery in parturients with class 3 obesity: a randomized controlled trial

BMC Anesthesiology
Background Spinal anesthesia with the conventional landmark technique can be challenging in parturients with morbid obesity. In the present study, the researchers examined the effects of ultrasound-assisted pre-puncture anesthesia in parturients with ...
Ayşegül Bilge, Betül Başaran
doaj   +1 more source

THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A

Advanced Science, EarlyView.
THSD7A exerts pro‐inflammatory effects and exacerbates atherosclerosis. Mechanistically, THSD7A regulates endothelial cell inflammation and atherosclerosis by activating the αvβ3/CEBPD/IL1A signaling axis. THSD7A is not only a genetic marker but also a potential therapeutic target for coronary artery disease (CAD).
Jiankun Liu, Hongfei Liu, Yiqi Wan, Andong Wu, Jiayu Qiu, Xueting Gong, Ya Zhao, Yuanyuan Li, Bingbing Zhou, Yangyi Zheng, Fang Wu, Yuanzheng Zhu, Weixin Lv, Xueer Li, Qiang Yuan, Xiao‐Li Tian   +15 more
wiley   +1 more source

Assessment of risk factors for postdural puncture headache in women undergoing cesarean delivery in Jordan: a retrospective analytical study

Local and Regional Anesthesia, 2017
Wail N Khraise,1 Mohammed Z Allouh,2 Khaled M El-Radaideh,1 Raed S Said,2 Anas M Al-Rusan1 1Department of Anesthesia, 2Department of Anatomy, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan Purpose: Postdural puncture ...
Khraise WN, Allouh MZ, El-Radaideh KM, Said RS, Al-Rusan AM   +4 more
doaj  

Impaired Chaperone‐Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation

Advanced Science, EarlyView.
This graphical abstract illustrates how chaperone‐mediated autophagy (CMA) regulates intervertebral disc degeneration (IDD). Under normal homeostasis (B), CMA degrades cytoplasmic Midnolin (MIDN) to maintain proteostasis. Under inflammatory stress (A), impaired CMA leads to cytoplasmic MIDN accumulation.
Xianglong Chen, Haiyang Gao, Wang Wu, Pengzhi Shi, Yuhang Chen, Anran Zhang, Zhangrong Cheng, Wenbo Wu, Zimu Yu, Yukun Zhang   +9 more
wiley   +1 more source

Intracranial subdural hematoma after epidural anesthesia: a case report and review of the literature

International Journal of Emergency Medicine, 2018
Background Intracranial subdural hematoma occurring as a result of a procedure that causes a puncture of the spinal dura mater is extremely rare, with less than 100 cases reported.
Victor Szeto, Justin Kosirog, Wesley Eilbert   +2 more
doaj   +1 more source