Results 51 to 60 of about 51,356 (243)

Grtp1 Safeguards Against Paternal Reproductive Aging and Intergenerational Behavioral Deficits by Preserving Redox Homeostasis

Advanced Science, EarlyView.
This study identifies that Grtp1 maintains germline redox homeostasis by interacting with PRDX1/4‐TXN to antagonize paternal reproductive aging. Growth hormone restores Grtp1 expression, rectifies aberrant sperm DNA methylation, and ameliorates intergenerational anxiety and social deficits, highlighting the GH‐GRTP1 axis as a promising intervention ...
Yingdong Liu, Shanyao Liu, Haixin Liang, Jiani Yang, Yanhe Li, Jiqing Yin, Xueguang Zhang, Yan Zhang, Dandan Bai, Zihui Yan, Zhuoao Zhang, Yanping Jia, Kuisheng Liu, Yifan Sheng, Jiani Xiang, Chenxiang Xi, Baoxing Dong, Xinyi Lei, Jiayu Chen, Hong Wang, Yi Guo, Yanping Zhang, Shaorong Gao, Wenqiang Liu   +23 more
wiley   +1 more source

Mechanically Robust, Self‐Healable, and Cryotolerant GelMA Hydrogel for Wearable Tactile Sensors with Enhanced Durability, Lifetime, and Environmental Stability

Advanced Science, EarlyView.
A mechanically robust, self‐healable, moisturizing, cryotolerant and adhesive GelMA hydrogel is developed by incorporating polyvinyl alcohol, acrylic acid, sodium tetraborate, and glycerol into GelMA matrix via a photoinitiated polymerization process. The hydrogel‐derived omni‐healable ionotronic pressure sensor can sensitively and consistently monitor
Zhikang Li, Gengyu Han, Boqing Jia, Jijian Lu, Changxu Zhang, Bin Wang, Jiaxiang Wang, Kang Zhao, Muhammad Afzal Khan Qureshi, Lan Yu, Min Li, Guoxi Luo, Tong Wang, Qijing Lin, Weishi Li, Libo Zhao, Yumeng Xue   +16 more
wiley   +1 more source

Postdural puncture headache and pregabalin

Journal of Pain Research, 2010
Beyazit ZencirciDepartment of Anesthesiology and Reanimation, Mostas Private Health Hospital, Kahramanmaras, TurkeyBackground: Even if carried out under optimal conditions, postdural puncture headache is still a frustrating and unpleasant complication in
Beyazit Zencirci
doaj  

Acid‐Responsive Nanobot‐Integrated Core‐Shell Microneedles Reprogram the Degenerative Annulus Fibrosus Microenvironment Through Epigenetic Suppression of Ferroptosis

Advanced Science, EarlyView.
An acid‐responsive core‐shell microneedle system normalizes the degenerative annulus fibrosus microenvironment by consuming pathological H+, generating O2, and providing NIR‐amplified redox buffering. Mechanistically, it epigenetically suppresses ferroptosis via DNMT3A‐dependent methylation of the ATF3 promoter, relieving ATF3‐mediated repression of ...
Lu Tan, Yan Zheng, Yue Lan, Zhuo Cheng, Siya Wang, Changqing Li, Yanqiu Wang, Minghan Liu   +7 more
wiley   +1 more source

Comparison of Two Different Pulsed Radiofrequency Modes for Prevention of Postherpetic Neuralgia in Elderly Patients with Acute/Subacute Trigeminal Herpes Zoster

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objective Trigeminal postherpetic neuralgia (PHN) is often refractory to treatment. Pulsed radiofrequency (PRF) neuromodulation can help in preventing PHN after herpes zoster. This study aimed to compare the efficacy and safety of two different PRF modes on gasserian ganglion neuromodulation in elderly patients with acute/subacute trigeminal ...
Cheng‐Fu Wan, Tao Song
wiley   +1 more source

A rare complication of spinal anesthesia: Intracranial subdural hemorrhage

Archives of Clinical and Experimental Surgery, 2015
Spinal (subarachnoid) anesthesia (SA) is a widely used general-purpose anesthesia. Postdural Puncture Headaches (PDPHs) represent one of the principal complications of spinal anesthesia.
Cengiz Kaplan, Ozgur Dandin, Erkan Kaya, Ferhat Cuce, Muzaffer Durmus, Ugur Karapinar, Tuncer Ergin   +6 more
doaj   +1 more source

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

Systematic Literature Review of Spinal Cord Stimulation in Patients With Chronic Back Pain Without Prior Spine Surgery

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objective Low back pain is the leading cause of disability worldwide and one of the most common reasons for seeking healthcare. Despite numerous care strategies, patients with low back pain continue to exhibit poor outcomes. Spinal cord stimulation (SCS) is an evidence‐based therapeutic modality for patients with failed back surgery syndrome ...
Jan M. Eckermann, Julie G. Pilitsis, Christopher Vannaboutathong, Belinda J. Wagner, Rose Province‐Azalde, Markus A. Bendel   +5 more
wiley   +1 more source

Hypobaric unilateral spinal anesthesia with multimodal analgesia enhances recovery in total knee arthroplasty

BMC Anesthesiology
Background Total knee arthroplasty (TKA) is an effective treatment for end-stage knee osteoarthritis, but postoperative pain and delayed recovery remain challenges.
Xiance Meng, Deli Wang, Xu Liu, Shiming Xia, Shunmei Zhang, Wei Wang, Yanan Wu, Guihua Huang   +7 more
doaj   +1 more source

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source