Results 81 to 90 of about 534,301 (305)
C. elegans chromosomes connect to centrosomes by anchoring into the spindle network
Nature Communications, 2016 The mitotic spindle ensures the faithful segregation of chromosomes. Here we combine the first large-scale serial electron tomography of whole mitotic spindles in early C.
S. Redemann +9 more
semanticscholar +1 more source
Force and the spindle: Mechanical cues in mitotic spindle orientation
Seminars in Cell & Developmental Biology, 2014 The mechanical environment of a cell has a profound effect on its behaviour, from dictating cell shape to driving the transcription of specific genes. Recent studies have demonstrated that mechanical forces play a key role in orienting the mitotic spindle, and therefore cell division, in both single cells and tissues.
Nestor-Bergmann, Alexander +2 more
openaire +3 more sources
The equatorial position of the metaphase plate ensures symmetric cell divisions
eLife, 2015 Chromosome alignment in the middle of the bipolar spindle is a hallmark of metazoan cell divisions. When we offset the metaphase plate position by creating an asymmetric centriole distribution on each pole, we find that metaphase plates relocate to the ...
Chia Huei Tan +6 more
doaj +1 more source
Cells, 2021 Tubulin post-translational modifications regulate microtubule properties and functions. Mitotic spindle microtubules are highly modified. While tubulin detyrosination promotes proper mitotic progression by recruiting specific microtubule-associated ...
Sylvia Fenosoa Rasamizafy +5 more
doaj +1 more source
Logspace computations for Garside groups of spindle type [PDF]
, 2013 M. Picantin introduced the notion of Garside groups of spindle type, generalizing the 3-strand braid group. We show that, for linear Garside groups of spindle type, a normal form and a solution to the conjugacy problem are logspace computable. For linear
Elder, Murray, Kalka, Arkadius
core
eLife, 2016 Mitotic spindle orientation is used to generate cell fate diversity and drive proper tissue morphogenesis. A complex of NuMA and dynein/dynactin is required for robust spindle orientation in a number of cell types.
L. Seldin, A. Muroyama, T. Lechler
semanticscholar +1 more source
The spindle assembly checkpoint [PDF]
Current Biology, 2008 (Current Biology 18, R391–R395; July 22, 2008)Because of an editorial mistake, Figure 1Figure 1 of this Primer shows pairs of kinetochores (indicated by pairs of yellow dots) during telophase, instead of single kinetochores as indicated in the corrected figure that appears here. The journal regrets this error.Figure 1The SAC as a synchronization device(
Varetti, Gianluca, Musacchio, Andrea
openaire +6 more sources
Reverse engineering of force integration during mitosis in the Drosophila embryo
Molecular Systems Biology, 2008 The mitotic spindle is a complex macromolecular machine that coordinates accurate chromosome segregation. The spindle accomplishes its function using forces generated by microtubules (MTs) and multiple molecular motors, but how these forces are ...
Roy Wollman +3 more
doaj +1 more source
eLife, 2018 Regulation of size and growth is a fundamental problem in biology. A prominent example is the formation of the mitotic spindle, where protein concentration gradients around chromosomes are thought to regulate spindle growth by controlling microtubule ...
Franziska Decker +3 more
doaj +1 more source
Open Biology, 2023 In somatic cells, mitotic transcription of major satellite non-coding RNAs is tightly regulated and essential for heterochromatin formation and the maintenance of genome integrity.
Claudia Baumann +3 more
doaj +1 more source