Results 81 to 90 of about 412,161 (357)

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

`Spindles' in symmetric spaces [PDF]

Journal of the Mathematical Society of Japan, 2006
We study families of submanifolds in symmetric spaces of compact type arising as exponential images of s-orbits of variable radii. Special attention is given to the cases where the s-orbits are symmetric.
openaire   +5 more sources

Coupling DNA Replication and Spindle Function in Saccharomyces cerevisiae

Cells, 2021
In the yeast Saccharomyces cerevisiae DNA replication and spindle assembly can overlap. Therefore, signaling mechanisms modulate spindle dynamics in order to ensure correct timing of chromosome segregation relative to genome duplication, especially when ...
Dimitris Liakopoulos
doaj   +1 more source

Phenotypic plasticity in a novel set of EGFR tyrosine kinase inhibitor‐adapted non‐small cell lung cancer cell lines

FEBS Open Bio, EarlyView.
Phenotypic plasticity in a newly established set of EGFR inhibitor‐adapted NSCLC cell lines during adaptation and in established cell lines. Here, we introduce novel sublines of the EGFR‐mutant non‐small cell lung cancer (NSCLC) cell lines HCC827 and HCC4006 adapted to the EGFR kinase inhibitors gefitinib (HCC827rGEFI2μm, HCC4006rGEFI1μm), erlotinib ...
Tharsagini V. Nanthaprakash, Campbell W. Gourlay, Ina Oehme, Michelle D. Garrett, Jindrich Cinatl Jr, Mark N. Wass, Martin Michaelis   +6 more
wiley   +1 more source

The mechanism of anaphase spindle elongation: uncoupling of tubulin incorporation and microtubule sliding during in vitro spindle reactivation. [PDF]

, 1988
To study tubulin polymerization and microtubule sliding during spindle elongation in vitro, we developed a method of uncoupling the two processes. When isolated diatom spindles were incubated with biotinylated tubulin (biot-tb) without ATP, biot-tb was ...
CANDE, W. Zacheus, Masuda, H, McDonald, K   +2 more
core  

On the Mass of Population III Stars [PDF]

, 1998
Performing 1D hydrodynamical calculations coupled with non-equilibrium processes for H2 formation, we pursue the thermal and dynamical evolution of filamentary primordial clouds and attempt to make an estimate on the mass of population III stars.
Black J., Carlberg R. G., Castor J. I., de Araujo J. C. N., Fumitaka Nakamura, Galli D., Kawachi T., Larson L., Larson L., Masayuki Umemura, Miyama S. M., Nakamura F., Penston M. V., Rees M. J., Silk J., Stodolkiewicz J. S., Sunyaev R. A., Yoneyama T., Yoshii Y., Zel'dovich Ya. B.   +19 more
core   +3 more sources

The spindle assembly checkpoint [PDF]

Current Biology, 2008
(Current Biology 18, R391–R395; July 22, 2008)Because of an editorial mistake, Figure 1Figure 1 of this Primer shows pairs of kinetochores (indicated by pairs of yellow dots) during telophase, instead of single kinetochores as indicated in the corrected figure that appears here. The journal regrets this error.Figure 1The SAC as a synchronization device(
Varetti, Gianluca, Musacchio, Andrea
openaire   +6 more sources

Intra-spindle Microtubule Assembly Regulates Clustering of Microtubule-Organizing Centers during Early Mouse Development

Cell Reports, 2016
Errors during cell division in oocytes and early embryos are linked to birth defects in mammals. Bipolar spindle assembly in early mouse embryos is unique in that three or more acentriolar microtubule-organizing centers (MTOCs) are initially formed and ...
Sadanori Watanabe, Go Shioi, Yasuhide Furuta, Gohta Goshima   +3 more
doaj   +1 more source

Effect of a Recliner Chair with Rocking Motions on Sleep Efficiency

Sensors, 2021
In this study, we analyze the effect of a recliner chair with rocking motions on sleep quality of naps using automated sleep scoring and spindle detection models.
Suwhan Baek, Hyunsoo Yu, Jongryun Roh, Jungnyun Lee, Illsoo Sohn, Sayup Kim, Cheolsoo Park   +6 more
doaj   +1 more source

Exploring patients’ profiles associated with the resolution of acute calcium pyrophosphate arthritis treatedwith colchicine and prednisone: post hoc analysis of a randomized controlled trial

Arthritis Care &Research, Accepted Article.
Objective The objective was to identify factors determining acute arthritis resolution and safety with colchicine and prednisone in acute calcium pyrophosphate (CPP) crystal arthritis. Methods We conducted a post hoc analysis of the COLCHICORT trial, which compared colchicine and prednisone for the treatment of acute CPP crystal arthritis, using a ...
Tristan Pascart, Laurène Norberciak, Pascal Richette, Pierre Robinet, Aurore Pacaud, Gauthier Marchasson, Thibault Rabin, Hélène Luraschi, Pierre Maciejasz, Anne‐France Georgel, Augustin Latourte, Hang‐Korng Ea, Sébastien Ottaviani, Charlotte Jauffret, Vincent Ducoulombier   +14 more
wiley   +1 more source