Results 81 to 90 of about 562,858 (399)

Kinesin-5-independent mitotic spindle assembly requires the antiparallel microtubule crosslinker Ase1 in fission yeast

Nature Communications, 2017
Bipolar spindle assembly requires a balance of forces where kinesin-5 produces outward pushing forces to antagonize the inward pulling forces from kinesin-14 or dynein.
Sergio A. Rincon, Adam R. Lamson, R. Blackwell, Viktoriya Syrovatkina, V. Fraisier, A. Paoletti, M. Betterton, P. Tran   +7 more
semanticscholar   +1 more source

Sarilumab in Polyarticular‐Course Juvenile Idiopathic Arthritis: Dose‐Finding and One‐Year Analysis of a Phase 2b, Open‐Label, Multicenter Study

Arthritis Care &Research, Accepted Article.
Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension‐phase). During part 1, three doses were assessed in two weight groups (Group A/B: ≥30–60 kg/≥10–<
Fabrizio De Benedetti, Inmaculada C. Penadés, Irina Nikishina, Ivan Foeldvari, Alberto J. Spindler, Anna Kozlova, Nadina Rubio‐Pérez, Pierre Quartier, Zbigniew Żuber, Raul Barria, Daniel Clemente, Gabriel V. Cornejo, Katherine Marzan, Nancy Liu, Christine Xu, Stephen DiMartino, Angeliki Giannelou, Fei Cao‐Ghoul, Bolanle Akinlade, Lydie Baret‐Cormel   +19 more
wiley   +1 more source

Echinoderm Microtubule Associated Protein Like 1 Is Indispensable for Oocyte Spindle Assembly and Meiotic Progression in Mice

Frontiers in Cell and Developmental Biology, 2021
Completion of the first meiosis is an essential prerequisite for producing a functionally normal egg for fertilization and embryogenesis, but the precise mechanisms governing oocyte meiotic progression remains largely unclear.
Hong Yin, Teng Zhang, Hao Wang, Xin Hu, Xuan Hou, Xianbao Fang, Yaoxue Yin, Hui Li, Lanying Shi, You-Qiang Su, You-Qiang Su, You-Qiang Su, You-Qiang Su   +12 more
doaj   +1 more source

E2F1 promotes cell cycle progression by stabilizing spindle fiber in colorectal cancer cells [PDF]

, 2022
Zejun Fang, Min Lin, Shenghui Chen, Hong Liu, Minjing Zhu, Yanyan Hu, Shanshan Han, Yizhang Wang, Sun Long, Fengjiao Zhu, Chengfu Xu, Chaoju Gong   +11 more
openalex   +1 more source

Liquid Crystal Elastomers Under Confinement: A Review of Template‐Based Fabrication and Applications

Advanced Engineering Materials, EarlyView.
Template‐assisted confinement offers powerful ways to control the alignment, structure, and function of liquid crystal elastomers. This review highlights several templating strategies and details how geometry and interfaces shape material responses.
Meng Zhang, Le Yang, Xinyi Ding, James Phillip Scarbrough, Tushar Narayan Singh, Yuxing Yao, Shucong Li, Xiaoguang Wang   +7 more
wiley   +1 more source

A bacteriophage tubulin harnesses dynamic instability to center DNA in infected cells. [PDF]

, 2014
Dynamic instability, polarity, and spatiotemporal organization are hallmarks of the microtubule cytoskeleton that allow formation of complex structures such as the eukaryotic spindle. No similar structure has been identified in prokaryotes.
Agard, David A, Chaikeeratisak, Vorrapon, Coker, Joanna KC, Erb, Marcella L, Kraemer, James A, Nonejuie, Poochit, Pogliano, Joe   +6 more
core   +2 more sources

A Vascular Microphysiological Model of Lung Fibrosis Reveals That Myofibroblasts and IPF Patient‐Derived Fibroblasts Impair Angiogenesis and Vasculogenesis

Advanced Functional Materials, EarlyView.
A microphysiological lung fibrosis model recapitulates myofibroblast–vascular interactions. Induced myofibroblasts and patient‐derived IPF fibroblasts impair angiogenesis and increase vascular permeability via TGF‐β1–driven signaling. Pharmacological interventions with SB 431542 and VEGF supplementation restore vascular morphology and barrier function.
Elena Cambria, Adriana Blazeski, Eunkyung Clare Ko, Tran Thai, Shania Dantes, David A. Barbie, Sarah E. Shelton, Roger D. Kamm   +7 more
wiley   +1 more source

The equatorial position of the metaphase plate ensures symmetric cell divisions

eLife, 2015
Chromosome alignment in the middle of the bipolar spindle is a hallmark of metazoan cell divisions. When we offset the metaphase plate position by creating an asymmetric centriole distribution on each pole, we find that metaphase plates relocate to the ...
Chia Huei Tan, Ivana Gasic, Sabina P Huber-Reggi, Damian Dudka, Marin Barisic, Helder Maiato, Patrick Meraldi   +6 more
doaj   +1 more source

Mechanical Mechanisms of Chromosome Segregation

Cells, 2021
Chromosome segregation—the partitioning of genetic material into two daughter cells—is one of the most crucial processes in cell division. In all Eukaryotes, chromosome segregation is driven by the spindle, a microtubule-based, self-organizing ...
Maya I. Anjur-Dietrich, Colm P. Kelleher, Daniel J. Needleman   +2 more
doaj   +1 more source

Measuring and modeling polymer gradients argues that spindle microtubules regulate their own nucleation

, 2017
Spindles are self-organized microtubule-based structures that segregate chromosomes during cell division. The mass of the spindle is controlled by the balance between microtubule turnover and nucleation. The mechanisms that control the spatial regulation
Foster, Peter J., Fürthauer, Sebastian, Kaye, Bryan, Needleman, Daniel J., Shelley, Michael J., Stiehl, Olivia   +5 more
core   +1 more source