Results 41 to 50 of about 940,923 (283)

Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1 [PDF]

, 2016
Brief periods of sleep loss have long-lasting consequences such as impaired memory consolidation. Structural changes in synaptic connectivity have been proposed as a substrate of memory storage.
Abel, Ted, Aton, Sara J., Baillie, George S., Bruinenberg, Vibeke M., Day, Jonathan P., Ferri, Sarah L., Hansen, Rolf T., Havekes, Robbert, Houslay, Miles D., Luczak, Vincent G., Meerlo, Peter, Park, Alan J., Poplawski, Shane G., Radwanska, Kasia, Tudor, Jennifer C.   +14 more
core   +6 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Does the Surgical Timing and Decompression Alone or Fusion Surgery in Lumbar Stenosis Influence Outcome in Cauda Equina Syndrome? [PDF]

Asian Spine Journal, 2019
Study Design A retrospective comparative analysis of 64 patients with cauda equina syndrome (CES), who underwent either decompression alone (NF) or fusion (F) surgery. Purpose We compared the outcomes and timing effects.
Bharat Rajendraprasad Dave, Puspak Samal, Romin Sangvi, Devanand Degulmadi, Denish Patel, Ajay Krishnan   +5 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Posterior lumbar fusion surgery doesn’t change sexual activities in patients with lumbar degenerative disease: an observational study

BMC Musculoskeletal Disorders, 2023
Background There are few studies about sexual function in the patient with posterior lumbar spinal fusion for degenerative lumbar disease. The aim of this study is to investigate sexual activities in patients with lumbar degenerative disease before and ...
Yukitoshi Shimamura, Masahiro Kanayama, Michiko Horio, Ai Yamaguchi, Fumihiro Oha, Takeru Tsujimoto, Masaru Tanaka, Yuichi Hasegawa, Tsutomu Endo, Tomoyuki Hashimoto   +9 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Acoustic Power Absorption and its Relation with Vector Magnetic Field of a Sunspot

, 2010
The distribution of acoustic power over sunspots shows an enhanced absorption near the umbra--penumbra boundary. Earlier studies revealed that the region of enhanced absorption coincides with the region of strongest transverse potential field. The aim of
A. Lagg, B. Pontieu De, B. Pontieu De, B.W. Hindman, B.W. Hindman, B.W. Lites, B.W. Lites, B.W. Lites, D. Berghmans, D. Wang, D.C. Braun, D.C. Braun, D.N. Rachkovsky, D.S. Bloomfield, E.N. Parker, G.B. Scharmer, H. Schunker, H. Zirin, I. Moortel De, J.A. Ionson, J.M. Davila, J.V. Hollweg, K. Ichimoto, K. Langhans, M. Landolfi, M.L. Demidov, P. Venkatakrishnan, P. Venkatakrishnan, P. Venkatakrishnan, P.H. Scherrer, P.S. Cally, R.B. Leighton, R.K. Ulrich, S. Chandrasekhar, S. Gosain, S. K. Mathew, S. Tsuneta, S.K. Mathew, T. Kosugi, T. Tran, W. Unno   +40 more
core   +1 more source

A relation on 132-avoiding permutation patterns [PDF]

, 2014
Rudolph conjectures that for permutations $p$ and $q$ of the same length, $A_n(p) \le A_n(q)$ for all $n$ if and only if the spine structure of $T(p)$ is less than or equal to the spine structure of $T(q)$ in refinement order.
Aisbett, Natalie
core   +2 more sources

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Geometric principles of second messenger dynamics in dendritic spines. [PDF]

, 2019
Dendritic spines are small, bulbous protrusions along dendrites in neurons and play a critical role in synaptic transmission. Dendritic spines come in a variety of shapes that depend on their developmental state.
Bartol, Thomas M, Cugno, Andrea, Iyengar, Ravi, Rangamani, Padmini, Sejnowski, Terrence J   +4 more
core   +1 more source