Results 51 to 60 of about 425,515 (269)

THE SURGERY OF THE SPINE

Annals of Surgery, 1889
n ...
openaire   +3 more sources

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Surgical Treatment of Lumbar Degenerative Problems with CD HORIZON BalanC Spinal System

Global Spine Journal, 2015
Introduction Adjacent segment degeneration (ASD) is a common (34%) problem following posterior spinal fusions which may deteriorate functional outcomes in long-term follow-up.
Meric Enercan, Bahadir Gokcen, Tunay Sanli, Neron Popovski, Sinan Kahraman, Erden Erturer, Cagatay Ozturk, Azmi Hamzaoglu   +7 more
doaj   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Dissecting the Genetic Basis of Low Back Pain Independent of BMI Through Genomic Structural Equation Modeling

Journal of Pain Research
Litao Huo,* Lin Tan,* Fei Wang,* Jing Sun, Yifan Niu, Ying Jiang, Mengzi Wu, Jialin Shi, Yongyu Hao, Jiaxu Wang, Shibo Huang, Zhiming Chen Department of Spine Surgery, The Ninth Medical Center of PLA General Hospital, Beijing ...
Huo L, Tan L, Wang F, Sun J, Niu Y, Jiang Y, Wu M, Shi J, Hao Y, Wang J, Huang S, Chen Z   +11 more
doaj  

Sacral Fractures

Global Spine Journal, 2016
Introduction Sacral fractures can result from a range of injury mechanisms. While sacral fractures typically result from high-energy injuries, there is increasing identification of low-energy insufficiency fractures of the sacrum and pelvis in elderly ...
Maria Luz Suarez-Huerta, Jesus Betegon-Nicolas, Paula Casas-Ramos, Marta Esteban-Blanco, Julio Villar-Perez, Jose Hernandez Encinas, Ana Isabel Lozano-Muñoz, Manuel Fernandez-Gonzalez   +7 more
doaj   +1 more source

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Self sliding growth guidance for early-onset scoliosis: Clinical and radiological results after a minimum of five years (5-13) of follow-up

Brain and Spine, 2021
Mustafa Eltayep, Recep Dincer, Ahmet Ates, Sina Coskun, Ugur Tasci, Ayhan Mutlu, Seray Gur, Sinan Kahraman, Tunay Sanli, Selhan Karadereler, Meric Enercan, Azmi Hamzaoglu   +11 more
doaj   +1 more source

Prognostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protein in ALD‐Related Myelopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background X‐linked adrenoleukodystrophy (X‐ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1, leading to slowly progressive spinal cord disease in nearly all affected men. Sensitive biomarkers to quantify disease severity and predict progression are needed for clinical care and trial design.
Eda G. Kabak, Marije M. C. Voermans, Hans Heijst, Charlotte E. Teunissen, Marc Engelen   +4 more
wiley   +1 more source