Results 41 to 50 of about 651,239 (267)

Lumbar Spine Location in Fluoroscopic Images by Evidence Gathering

, 2000
Low back pain (LBP) is a very common problem and lumbar segmental instability is one of the causes. It is important to investigate lumbar spine movement in order to understand instability better and as an aid to diagnosis.
Allen, Robert, Nixon, Mark S., Zheng, Yalin   +2 more
core   +1 more source

Identification of the Hub Genes Involved in Stem Cell Treatment for Intervertebral Disc Degeneration: A Conjoint Analysis of Single-Cell and Machine Learning

Stem Cells International, 2023
Intervertebral disc degeneration (IDD), which is distinguished by a variety of pathologic alterations, is the major cause of low back pain (LBP). Nonetheless, preventative measures or therapies that may delay IDD are scarcely available. In this study, we
Jianfeng Chen, Fuwei Qi, Guanshen Li, Qiaosong Deng, Chenlin Zhang, Xiaojun Li, Yafeng Zhang   +6 more
doaj   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Early Intervention in Post-operative Infectious Spondylodiscitis: Outcome of Aggressive Transforaminal Lumbar Interbody Fusion [PDF]

Malaysian Orthopaedic Journal
Introduction: Conservative and surgical approach timeline in post-operative spondylodiscitis (POS) following lumbar disc herniation (LDH) surgery is ill defined, and patients have a protracted recovery phase with social, psychological, and financial ...
Krishnan A, Dave BR, Degulmadi D, Mayi S, Rai R, Bang P, Dave M, Chauhan V, Bali S, Charde P, Anil A, Krishnan P   +11 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Long Spine Mooring [PDF]

, 1986
In this report we present the specification of the mooring for the long spine model, and a detailed analysis of its static and dynamic characteristics. We describe the experimental investigations of the behaviour of the mooring alone, and coupled to the ...
Retzler, Chris-Heinz
core  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Successful Treatment of Severe Occipitocervical Pain from C1-C2 Osteoarthritis Using a Modified Harms Technique

Global Spine Journal, 2016
Introduction C1-C2 fusion with instrumentation is an established treatment for C1-C2 instability due to trauma or inflammatory disease. C1-C2 fusion for debilitating occipitocervical pain secondary to C1-C2 osteoarthritis has been reported in a small ...
Ara Deukmedjian, Augusto Cianciabella, Bharat Patel, Arias Deukmedjian   +3 more
doaj   +1 more source

Radiographic Outcomes of Adult Spinal Deformity Correction : A Critical Analysis of Variability and Failures Across Deformity Patterns [PDF]

, 2014
Study Design: Multicenter, prospective, consecutive, surgical case series from the International Spine Study Group. Objectives: To evaluate the effectiveness of surgical treatment in restoring spinopelvic (SP) alignment.
PRAVEEN, Mummaneni, KLINEBERG, Eric, HART, Robert, SKALLI, Wafa, SMITH, Justin, RYAN, Devon, OHENEBA, Boachie-Adjei, TERRAN, Jamie, SHAFFREY, Christopher, AMES, Christopher, AMES, Christopher P., LAFAGE, Virginie, SCHWAB, Franck, MOAL, Bertrand, Shaffrey, Christopher I., Hart, Robert A., Schwab, Frank, Virginie, Lafage, Lafage, V, Smith, Justin S., Schwab, F, Shaffrey, CI, Boachie-Adjei, Oheneba, Smith, JS, Boachie-Adjei, O, Mundis, GM, Klineberg, E, Ames, CP, Terran, Jamie S., Hart, RA, Mummaneni, PV, Moal, B, Skalli, W, Terran, JS, Mundis Jr, Gregory M., Ryan, D, Mummaneni, Praveen V.   +36 more
core   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source