Results 41 to 50 of about 1,059,853 (352)

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

Dendritic spine geometry and spine apparatus organization govern the spatiotemporal dynamics of calcium. [PDF]

, 2019
Dendritic spines are small subcompartments that protrude from the dendrites of neurons and are important for signaling activity and synaptic communication. These subcompartments have been characterized to have different shapes.
Bartol, Tom, Bell, Miriam, Rangamani, Padmini, Sejnowski, Terrence   +3 more
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Application of Percutaneous Dynamic Interspinous Stabilization in Lumbar Spine in Combination with Percutaneous Intradiscal Laser Nucleotomy

Global Spine Journal, 2012
Study Design Comparison outcome treatment of pain syndromes in lumbar degenerative disk disease (DDD) in application two combined minimally invasive methods of treatment in intervertebral disk (IVD) herniations.
S. K. Makirov, N. G. Goncharov, V. G. Golubev, S. V. Susin, O. A. Zuraev, V. V. Vasilyev, B. A. Sychenikov, R. M. Nurmukhametov, A. P. Tarasov   +8 more
doaj   +1 more source

Resolving the Fan-Spine Reconnection Geometry of a Small-Scale Chromospheric Jet Event with the New Solar Telescope

, 2016
Jets present ubiquitously in both quiet and active regions on the Sun. They are widely believed to be driven by magnetic reconnection. A fan-spine structure has been frequently reported in some coronal jets and flares, regarded as a signature of ongoing ...
Cao, Wenda, Chen, Bin, Goode, Philip R., Ji, Haisheng, Zeng, Zhicheng   +4 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Identification of the Hub Genes Involved in Stem Cell Treatment for Intervertebral Disc Degeneration: A Conjoint Analysis of Single-Cell and Machine Learning

Stem Cells International, 2023
Intervertebral disc degeneration (IDD), which is distinguished by a variety of pathologic alterations, is the major cause of low back pain (LBP). Nonetheless, preventative measures or therapies that may delay IDD are scarcely available. In this study, we
Jianfeng Chen, Fuwei Qi, Guanshen Li, Qiaosong Deng, Chenlin Zhang, Xiaojun Li, Yafeng Zhang   +6 more
doaj   +1 more source

Iatrogenic Spinal Cord Injury Resulting From Cervical Spine Surgery. [PDF]

, 2017
STUDY DESIGN: Retrospective cohort study of prospectively collected data. OBJECTIVE: To examine the incidence of iatrogenic spinal cord injury following elective cervical spine surgery.
Arnold, Paul M., Buser, Zorica, Currier, Bradford L., Daniels, Alan H., Fehlings, Michael G., Fish, David E., Hart, Robert A., Hilibrand, Alan S., Lord, Elizabeth L., Mroz, Thomas E., Nassr, Ahmad, Riew, K. Daniel, Sebastian, Arjun S., Stroh, D. Alex, Tortolani, P. Justin, Wang, Jeffrey C.   +15 more
core   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Successful Treatment of Severe Occipitocervical Pain from C1-C2 Osteoarthritis Using a Modified Harms Technique

Global Spine Journal, 2016
Introduction C1-C2 fusion with instrumentation is an established treatment for C1-C2 instability due to trauma or inflammatory disease. C1-C2 fusion for debilitating occipitocervical pain secondary to C1-C2 osteoarthritis has been reported in a small ...
Ara Deukmedjian, Augusto Cianciabella, Bharat Patel, Arias Deukmedjian   +3 more
doaj   +1 more source