Results 51 to 60 of about 982,626 (335)

Activation of tyrosine kinases by mutation of the gatekeeper threonine. [PDF]

, 2008
Protein kinases targeted by small-molecule inhibitors develop resistance through mutation of the gatekeeper threonine residue of the active site. Here we show that the gatekeeper mutation in the cellular forms of c-ABL, c-SRC, platelet-derived growth ...
Azam, Mohammad, Daley, George, Gray, Nathanael, KURIYAN, John, Seeliger, Markus   +4 more
core   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1 [PDF]

, 2016
Brief periods of sleep loss have long-lasting consequences such as impaired memory consolidation. Structural changes in synaptic connectivity have been proposed as a substrate of memory storage.
Abel, Ted, Aton, Sara J., Baillie, George S., Bruinenberg, Vibeke M., Day, Jonathan P., Ferri, Sarah L., Hansen, Rolf T., Havekes, Robbert, Houslay, Miles D., Luczak, Vincent G., Meerlo, Peter, Park, Alan J., Poplawski, Shane G., Radwanska, Kasia, Tudor, Jennifer C.   +14 more
core   +5 more sources

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Safety and Efficacy of Polyetheretherketone (PEEK) Cages and Cadaveric Allografts in Transforaminal Lumbar Interbody Fusion (TLIF) for Treating Lumbar Pyogenic Spondylodiscitis

Mediators of Inflammation, 2023
Purpose. There have been many studies in the operative management of pyogenic spondylodiscitis with foreign materials. However, it still remains an issue of debate on whether the allografts may be used in pyogenic spondylodiscitis.
Huo-Liang Zheng, Bo Li, Shao-Kuan Song, Peng-Bo Chen, Xin-Feng Zheng, Lei-Sheng Jiang, Sheng-Dan Jiang   +6 more
doaj   +1 more source

Biophysical characterization and ion transport with cell‐based and proteoliposome reconstitution assays of invertebrate K+‐Cl− cotransporters

FEBS Open Bio, EarlyView.
The K+‐Cl− cotransporters (KCCs) facilitate the symport of ions across the plasma membrane. They participate in physiological processes including neuronal regulation. Here, we characterized KCCs from Drosophila and Hydra vulgaris. Comparative analyses of transporters provide insights into the mechanism of KCC ion transport, regulation, and evolution ...
Satoshi Fudo, Marina Verkhovskaya, Coralie Di Scala, Claudio Rivera, Tommi Kajander   +4 more
wiley   +1 more source

Beyond p‐values: Assessing clinical significance in acupuncture research

Advanced Chinese Medicine, EarlyView.
Abstract In acupuncture randomized controlled trials (RCTs), the proper interpretation of results requires a thorough understanding of key statistical concepts such as p‐value, effect size, and the minimal clinically important difference (MCID). This paper explores the relationships among these metrics and their implications for assessing the clinical ...
Changzhen Gong
wiley   +1 more source

Transforaminal lumbar interbody fusion with a tantalum cage: lumbar lordosis redistribution and sacral slope restoration with a modified posterior technique

Journal of Orthopaedics and Traumatology, 2023
Background Transforaminal lumbar interbody fusion (TLIF), a commonly used procedure in spine surgery, has the advantage of a lower incidence of nerve lesions compared to the posterior lumbar interbody fusion (PLIF) technique. The intersomatic arthrodesis
Marcello Ferraro, Francesco Puglia, Andrea Della Valle, Vincenzo Cerbone, Alfonso Cicatelli, Donata Rita Peroni, Davide Cecconi, Bernardo Misaggi, Giovanni Andrea La Maida   +8 more
doaj   +1 more source

Acoustic Power Absorption and its Relation with Vector Magnetic Field of a Sunspot

, 2010
The distribution of acoustic power over sunspots shows an enhanced absorption near the umbra--penumbra boundary. Earlier studies revealed that the region of enhanced absorption coincides with the region of strongest transverse potential field. The aim of
A. Lagg, B. Pontieu De, B. Pontieu De, B.W. Hindman, B.W. Hindman, B.W. Lites, B.W. Lites, B.W. Lites, D. Berghmans, D. Wang, D.C. Braun, D.C. Braun, D.N. Rachkovsky, D.S. Bloomfield, E.N. Parker, G.B. Scharmer, H. Schunker, H. Zirin, I. Moortel De, J.A. Ionson, J.M. Davila, J.V. Hollweg, K. Ichimoto, K. Langhans, M. Landolfi, M.L. Demidov, P. Venkatakrishnan, P. Venkatakrishnan, P. Venkatakrishnan, P.H. Scherrer, P.S. Cally, R.B. Leighton, R.K. Ulrich, S. Chandrasekhar, S. Gosain, S. K. Mathew, S. Tsuneta, S.K. Mathew, T. Kosugi, T. Tran, W. Unno   +40 more
core   +1 more source

Shoulder pain due to cervical radiculopathy: an underestimated long-term complication of herpes zoster virus reactivation? [PDF]

, 2018
Purpose To evaluate if herpes zoster virus (HZV) reactivation may be considered in the aetiology of cervical radiculopathy. Methods The study group was composed of 110 patients (52 M-58F;mean age ± SD:46.5 ± 6.12; range:40-73) with a clinical ...
AS Hilibrand, B Kuijper, Ciro Villani, DA Perez-Martienz, Daniele Passaretti, DH Gilden, E Viikari-Juntura, H Sandmark, HC Tong, I Steiner, JP Makela, K Radhakrishnan, KC Shah, KM Abbed, MC Sanchez, MM Ban Le, MM Vargo, MT Modic, MT Modic, NA Peterslund, PG Kennedy, PW Detwiler, R Atkinson, RE Yoss, RS Wainner, RW Johnson, S Gumina, S Shabat, Stefano Gumina, T Fujy, Vittorio Candela, W Frobin, W Frobin, W Frobin, Y Uematsu   +34 more
core   +1 more source