Results 141 to 150 of about 315,999 (305)

Pulsatilla saponin D regulates ras-related C3 botulinum toxin substrate 3 (RAC3) to overcome resistance to paclitaxel in lung adenocarcinoma cells

BMC Cancer
Background Paclitaxel, a tubulin-binding agent, is a Food and Drug Administration-approved first-line drug for the treatment of non-small cell lung cancer (NSCLC), for both squamous and non-squamous cell lung carcinoma, with paclitaxel/carboplatin ...
Yanyan Lu, Wubin He, Xiaoxu Huang, Xuyang Xiao   +3 more
doaj   +1 more source

Neuroimmune Microenvironment Reprogramming via Immuno‐piezoelectric Transducers for Synergistic Stem Cell Therapy in Traumatic Brain Injury

Advanced Materials, EarlyView.
A novel immuno‐piezoelectric transducer is innovatively developed. This device promotes neural stem cell (NSC) differentiation and maturation via ultrasound‐induced electrical stimulation and it amplifies the therapeutic efficacy of NSC in traumatic brain injury (TBI) by modulating the immune microenvironment. This piezoelectric transducer with “immune‐
Linlin Liang, Xin Li, Kai Hu, Pingqiang Cai, Jianwu Wang, Jing Yu, Shasha Wang, Yuwei Zhao, Changgeng Xu, Siwei Li, Hong Liu, Changyong Wang, Jin Zhou   +12 more
wiley   +1 more source

The adhesion-GPCR ADGRF5 fuels breast cancer progression by suppressing the MMP8-mediated antitumorigenic effects

Cell Death and Disease
ADGRF5 (GPR116) has been identified as a facilitator of breast cancer cell migration and metastasis, yet the underlying mechanisms remain largely elusive.
Yalan Wu, Huixia Liu, Zhe Sun, Jieling Liu, Kai Li, Ronghui Fan, Fujun Dai, Hui Tang, Qi Hou, JinSong Li, Xiaolong Tang   +10 more
doaj   +1 more source

Estradiol: Mediator of memories, spine density and cognitive resilience to stress in female rodents

Journal of Steroid Biochemistry and Molecular Biology, 2016
V. Luine
semanticscholar   +1 more source

Dynamic, Reconfigurable, and Hierarchical Biosynthetic Composites via Collagen Self‐Assembly within Highly Crowded Microgel Pastes

Advanced Materials, EarlyView.
A new approach to extracellular matrix‐mimetic, hierarchical biomaterials is presented. Soft gels composed of overpacked hydrogel microparticle arrays present a biomolecularly crowded environment permissive to the self‐assembly of collagen networks.
Elif Narbay, Abbygail Caine, Sanika Pandit, Gabrielle Montgomery, Marion Harper, E. Daniel Cárdenas‐Vásquez, Hatte Hamilton, Megan Hicks, Daniel Mattar, Kyle Choy, Marco Bisoffi, L. Andrew Lyon   +11 more
wiley   +1 more source

Tumor suppressor BAP1 suppresses disulfidptosis through the regulation of SLC7A11 and NADPH levels

Oncogenesis
BAP1, BRCA1-Associated Protein 1, serves as a novel tumor suppressor through the deubiquitination of monoubiquitination of H2A and subsequent gene transcriptional regulation.
Jin Wang, Minglin Wang, Shaobo Wu, Yanan Zhu, Kexin Fan, Yuhan Chen, Zhengtao Xiao, Jing Chen, Kangsheng Tu, Dongsheng Huang, Yilei Zhang, Qiuran Xu   +11 more
doaj   +1 more source

Ferroelectrics Hybrids: Harnessing Multifunctionality of 2D Semiconductors in the Post‐Moore Era

Advanced Materials, EarlyView.
In this Review, the state of art of ferroelectric hybrid systems—combining ferroelectrics, 2D semiconductors, and molecular switches is presented—as next‐generation platforms for high‐density, multifunctional electronics. By discussing 2D FeFET applications, nanoscale material downscaling, M3D integration, and emerging ferroelectrics, it highlights ...
Haixin Qiu, Xiaoshi Qian, Dahong Qian, Paolo Samorì   +3 more
wiley   +1 more source

Study protocol for putting the ‘Person’ in the PiCTuRE: an exploratory sequential mixed methods-based design, exploring how precision medicine is implemented and experienced by people living with a primary tumour of the craniospinal axis

BMC Cancer
Introduction Primary tumours of the brain and spine are rare, heterogeneous, and frequently associated with significant morbidity and mortality. Advances in precision oncology and personalised medicine offer the potential to accelerate diagnosis, improve
Gerard Mawhinney, Helen Higham, Simon Leedham, Olaf Ansorge   +3 more
doaj   +1 more source

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

Piezoelectric Stimulation of Neural Cells: Exploring the Synergistic Potential of Hybrid Scaffolds for Enhanced Regeneration

Advanced Materials Interfaces, EarlyView.
Hybrid piezoelectric scaffolds offer a promising route for Central Nervous System regeneration by combining structural and electrical cues to support neural stem cell growth. This review highlights their potential to overcome current challenges in neural tissue engineering by exploring porous hybrid materials, their biological interactions, and ...
Heather F. Titterton, Chris R. Bowen, Hamideh Khanbareh   +2 more
wiley   +1 more source