Results 11 to 20 of about 42,472 (219)

Synaptic micromechanics and brain softening as a mechanobiological hypothesis for Alzheimer’s disease [PDF]

Frontiers in Neuroscience
Alzheimer’s disease (AD) is usually framed as a proteinopathy and network disorder, but this view may be incomplete. We propose a mechanobiological hypothesis in which synaptic micromechanics, regional brain softening, vascular pulsatility, and ...
Denis Le Bihan
doaj   +2 more sources

The temporal and spatial expression of sclerostin and Wnt signaling factors during the maturation of posterolateral lumbar spine fusions

JOR Spine, 2021
The bone healing environment in the posterolateral spine following arthrodesis surgery is one of the most challenging in all of orthopedics and our understanding of the molecular signaling pathways mediating osteogenesis during spinal fusion is limited ...
John Rodriguez‐Feo, Lorenzo Fernandes, Anuj Patel, Thanh Doan, Scott D. Boden, Hicham Drissi, Steven M. Presciutti   +6 more
doaj   +1 more source

Multimodal pathophysiological dataset of gradual cerebral ischemia in a cohort of juvenile pigs

Scientific Data, 2021
Measurement(s) EEG with persistent abnormal rhythmic activity • electrocardiogram • Electrothalamogram • cerebral blood flow measurement • positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure •
Martin G. Frasch, Bernd Walter, Christophe L. Herry, Reinhard Bauer   +3 more
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Induction of Skeletal Muscle Injury by Intramuscular Injection of Cardiotoxin in Mouse

Bio-Protocol, 2023
Skeletal muscle is the most abundant tissue in the human body and has a tremendous capability to regenerate in response to muscle injuries and diseases. Induction of acute muscle injury is a common method to study muscle regeneration in vivo. Cardiotoxin
Xin Fu, Sheng Li, Minzhi Jia, Wenjun Yang, Ping Hu   +4 more
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First person – Hao Lu

Biology Open, 2020
First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers.
doaj   +1 more source

Inflammatory Profiling of Patients Undergoing Lumbar Interbody Fusion by Different Approaches: In Search for Markers of Mini-invasiveness

Global Spine Journal, 2016
Introduction Minimally-invasive surgeries have become routinely adopted due to reduced tissue trauma and damage. In spine surgery, and particularly lumbar interbody fusion (LIF) procedures, several minimal invasive approaches are available.
Giovanni Lombardi, Pedro Berjano, Riccardo Cecchinato, Silvia Perego, Veronica Sansoni, Fulvio Tartara, Giuseppe Banfi, Claudio Lamartina   +7 more
doaj   +1 more source

The combination of three-dimensional and rotary cell culture system promotes the proliferation and maintains the differentiation potential of rat BMSCs

Scientific Reports, 2017
Bone marrow mesenchymal stem cells (BMSCs) are a good candidate for tissue engineering and clinical application. One of the challenges in its cell therapy is how to quickly obtain an adequate number of seed cells and meanwhile maintain suitable ...
Yilong Tang, Yan Xu, Zhifeng Xiao, Yannan Zhao, Jing Li, Sufang Han, Lei Chen, Bin Dai, Ling Wang, Bing Chen, Hong Wang   +10 more
doaj   +1 more source

Elevated Antibody Titers to Epstein–Barr Virus and Cytomegalovirus in Patients with Drug-Induced Lupus

Viruses, 2023
Systemic lupus erythematosus (SLE) is an autoimmune disease, which has been associated with Epstein–Barr virus (EBV) and Cytomegalovirus (CMV) infection.
Julie Knudsen, Nicole Hartwig Trier, Anette Holck Draborg, Christoffer Tandrup Nielsen, Søren Jacobsen, Peter Højrup, Gunnar Houen   +6 more
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Hypoxia-sensitive long noncoding RNA CASC15 promotes lung tumorigenesis by regulating the SOX4/β-catenin axis

Journal of Experimental & Clinical Cancer Research, 2021
Background Accumulating evidence has demonstrated that long non-coding RNAs (lncRNAs) are involved in the hypoxia-related cancer process and play pivotal roles in enabling malignant cells to survive under hypoxic stress.
Jianyong Sun, Yanlu Xiong, Kuo Jiang, Bo Xin, Tongtong Jiang, Renji Wei, Yuankang Zou, Hong Tan, Tao Jiang, Angang Yang, Lintao Jia, Lei Wang   +11 more
doaj   +1 more source

Is Minimally Invasive Spine Surgery Also Minimally Pro-Inflammatory? Muscular Markers, Inflammatory Parameters and Cytokines to Quantify the Operative Invasiveness Assessment in Spine Fusion

European Journal of Inflammation, 2014
Over the last decades, minimally invasive surgery (MIS) techniques entered in the surgical routine due to their major advantage in reducing the unnecessary exposure of tissue and, thus, the trauma.
G. Lombardi, D. Grasso, P. Berjano, G. Banfi, C. Lamartina   +4 more
doaj   +1 more source