Results 11 to 20 of about 42,556 (266)

Molecular Developmental Biology of Fibrodysplasia Ossificans Progressiva: Measuring the Giant by Its Toe

Biomolecules
When a genetic disease is characterized by the abnormal activation of normal molecular pathways and cellular events, it is illuminating to critically examine the places and times of these activities both in health and disease.
O. Will Towler, Eileen M. Shore, Frederick S. Kaplan   +2 more
doaj   +2 more sources

ADP-ribosylation factor 6 (ARF6) bidirectionally regulates dendritic spine formation depending on neuronal maturation and activity [PDF]

, 2018
Recent studies have reported conflicting results regarding the role of ARF6 in dendritic spine development, but no clear answer for the controversy has been suggested.
Kim Y., Kim M., Lee S.-E., Daehee Hwang, Park J., Chang S., Lee B.   +6 more
core   +2 more sources

The temporal and spatial expression of sclerostin and Wnt signaling factors during the maturation of posterolateral lumbar spine fusions

JOR Spine, 2021
The bone healing environment in the posterolateral spine following arthrodesis surgery is one of the most challenging in all of orthopedics and our understanding of the molecular signaling pathways mediating osteogenesis during spinal fusion is limited ...
John Rodriguez‐Feo, Lorenzo Fernandes, Anuj Patel, Thanh Doan, Scott D. Boden, Hicham Drissi, Steven M. Presciutti   +6 more
doaj   +1 more source

Study of dendritic spine compartmentalization : a correlative fluorescence light microscopy-electron microscopy approach [PDF]

, 2014
Neurons communicate with each other through synapses. Most excitatory synapses contact small protrusions called dendritic spines. Spines are connected to dendrites by a very thin stalk called the “spine neck” which restricts diffusion between the spine ...
Cyprien, Vivien
core   +1 more source

Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice [PDF]

, 2010
The pathology of Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β (Aβ) peptide, hyperphosphorylated tau protein, neuronal death, and synaptic loss.
Fuhrmann Martin, Kretzschmar Hans, Ochs, Simon M., Herms Jochen, Simon M Ochs, Burgold Steffen, Jochen Herms, Frank M LaFerla, Burgold, Steffen, Herms, Jochen, Hans Kretzschmar, Gerda Mitteregger, Fuhrmann, Martin, Kretzschmar, Hans, Ochs Simon M., Frank M. Laferla, LaFerla Frank M., Hoffmann, Nadine, LaFerla, Frank M., Bittner, Tobias, Bittner Tobias, Mitteregger, Gerda, Nadine Hoffmann, Simon M. Ochs, Martin Fuhrmann, Tobias Bittner, Hoffmann Nadine, Steffen Burgold, Mitteregger Gerda   +28 more
core   +1 more source

Induction of Skeletal Muscle Injury by Intramuscular Injection of Cardiotoxin in Mouse

Bio-Protocol, 2023
Skeletal muscle is the most abundant tissue in the human body and has a tremendous capability to regenerate in response to muscle injuries and diseases. Induction of acute muscle injury is a common method to study muscle regeneration in vivo. Cardiotoxin
Xin Fu, Sheng Li, Minzhi Jia, Wenjun Yang, Ping Hu   +4 more
doaj   +1 more source

Multimodal pathophysiological dataset of gradual cerebral ischemia in a cohort of juvenile pigs

Scientific Data, 2021
Measurement(s) EEG with persistent abnormal rhythmic activity • electrocardiogram • Electrothalamogram • cerebral blood flow measurement • positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure •
Martin G. Frasch, Bernd Walter, Christophe L. Herry, Reinhard Bauer   +3 more
doaj   +1 more source

Spinal cord trauma and the molecular point of no return [PDF]

, 2012
A mechanical trauma to the spinal cord can be followed by the development of irreversible and progressive neurodegeneration, as opposed to a temporary or partially reversible neurological damage.
Yip, PK, Malaspina Andrea, Andrea Malaspina, Yip Ping K, Malaspina, A, Ping K Yip   +5 more
core   +1 more source

Dendritic spines as chemical and electrical compartments : a two-photon imaging study in the hippocampus of the rat [PDF]

, 2008
Most excitatory synapses are located on small dendritic protrusions called spines. So far, the function of dendritic spines is not fully understood. Imaging experiments have shown that spines can compartmentalize second messengers such as Ca2+.
Müller-Grunditz, Åsa
core   +1 more source

First person – Hao Lu

Biology Open, 2020
First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers.
doaj   +1 more source