Results 21 to 30 of about 42,472 (219)

Artesunate Regulates Neurite Outgrowth Inhibitor Protein B Receptor to Overcome Resistance to Sorafenib in Hepatocellular Carcinoma Cells

Frontiers in Pharmacology, 2021
The multireceptor tyrosine kinase inhibitor sorafenib is a Food and Drug Administration-approved first-line drug for the treatment of advanced liver cancer that can reportedly extend overall survival in patients with advanced hepatocellular carcinoma ...
Wubin He, Xiaoxu Huang, Bradford K. Berges, Yue Wang, Ni An, Rongjian Su, Yanyan Lu   +6 more
doaj   +1 more source

Update to the dataset of cerebral ischemia in juvenile pigs with evoked potentials

Scientific Data, 2021
Measurement(s) Abnormal auditory evoked potentials • Abnormality of somatosensory evoked potentials • high frequency oscillations • brain activity Technology Type(s) Electrocorticography • electrothalamography Factor Type(s) anesthesia • analgosedation •
Martin G. Frasch, Bernd Walter, Christoph Anders, Reinhard Bauer   +3 more
doaj   +1 more source

Sa12b-Modified Functional Self-Assembling Peptide Hydrogel Enhances the Biological Activity of Nucleus Pulposus Mesenchymal Stem Cells by Inhibiting Acid-Sensing Ion Channels

Frontiers in Cell and Developmental Biology, 2022
Various hydrogels have been studied for nucleus pulposus regeneration. However, they failed to overcome the changes in the acidic environment during intervertebral disc degeneration.
Letian Han, Letian Han, Ziyu Wang, Haoyu Chen, Haoyu Chen, Jie Li, Shengquan Zhang, Sumei Zhang, Shanzhong Shao, Shanzhong Shao, Yinshun Zhang, Yinshun Zhang, Cailiang Shen, Cailiang Shen, Hui Tao, Hui Tao   +15 more
doaj   +1 more source

Gene therapy genetic aspects and possibilities for degenerative diseases of intervertebral disks treatment

Ukrainian Neurosurgical Journal, 2008
At the beginning of 90th past century, due to intensive development of molecular biology and tissue engineering, knowledge accumulation about growth factors influence on the intervertebral disc cells, became possible.
E. G. Pedachenko, K. I. Horbatyuk
doaj   +1 more source

PRIMUS: Comprehensive proteomics of mouse intervertebral discs that inform novel biology and relevance to human disease modelling

Matrix Biology Plus, 2021
Mice are commonly used to study intervertebral disc (IVD) biology and related diseases such as IVD degeneration. Discs from both the lumbar and tail regions are used.
Mateusz Kudelko, Peikai Chen, Vivian Tam, Ying Zhang, Oi-Yin Kong, Rakesh Sharma, Tiffany Y.K. Au, Michael Kai-Tsun To, Kathryn S.E. Cheah, Wilson C.W. Chan, Danny Chan   +10 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Disorientation effects, circulating small ribonucleic acid, and genetic susceptibility on static postural stability

Heliyon, 2023
Background: Motion Sickness increases risk of performance deficits and safety of flight concerns. The etiology of motion sickness is poorly understood.
Ashley Turner, Michael Markey, Peter Le, Ali Reiter, Cyndy Cox, Stacy Simmons, M.B. Rao, Lorenna Altman, Kermit Davis, Dustin Huber, Jonathan S. Dufour, William Marras, Amit Bhattacharya   +12 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source