Results 71 to 80 of about 42,556 (266)

Structural and molecular distinctions of primary and secondary spines in the sea urchin Lytechinus variegatus

Scientific Reports
Sea urchins (echinoids) are common model organisms for research in developmental biology and for their unusual transition from a bilaterally organized larva into a post-metamorphic adult with pentaradial body symmetry.
Elise Hebert, Madison Silvia, Gary M. Wessel   +2 more
doaj   +1 more source

Application of Ibuprofen Sodium Dihydrate for Thermochemical Energy Storage

Advanced Functional Materials, EarlyView.
Ibuprofen sodium dihydrate is introduced as a durable organic salt hydrate for low‐temperature thermochemical energy storage, operating within 60°C–110°C with high energy density. At the material level, it delivers ∼99.9% cycling efficiency over 150 cycles without deliquescence, enabled by a dual energy‐storage mechanism coupling dehydration and phase ...
Kavin Chakravarthy Thangaraj, Hannah F. Chang, Shannon J. Lee, Mark E. Bowden, J. David Bazak, Vaithiyalingam Shutthanandan, Venkateshkumar Prabhakaran, Xiao Zhang, David M. Reed, Ajay S. Karakoti, Vijayakumar Murugesan   +10 more
wiley   +1 more source

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

Advanced Functional Materials, EarlyView.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins, Callan D. McLoughlin, Wan‐Kyu Ko, Hye Kyu Choi, Brandon Conklin, Joshua B. Stein, Yannan Hou, Hongwon Kim, Rohan Khulbe, Ki‐Bum Lee   +9 more
wiley   +1 more source

The 2nd Berlin BedRest study: protocol and implementation [PDF]

, 2010
Long-term bed-rest is used to simulate the effect of spaceflight on the human body and test different kinds of countermeasures. The 2nd Berlin BedRest Study (BBR2-2) tested the efficacy of whole-body vibration in addition to high-load resisitance ...
Bock, O., Salanova, M., Stegeman, Dick F, Blottner, Dieter, Bock, Oliver, de Heer, M., Habazettl, Helmut, Cerretelli, Paolo, Börst, Hendrikje, Gast, Ulf, Salanova, Michele, Soll, Henning, Degner, C., Beller, G., Habazettl, h., Stegeman, D.F., Belavy, D. L., Stegeman, D. F., de Haan, A., Felsenberg, D., de Haan, Arnold, Heer, M. de, Armbrecht, G., Haan, A. de, Blottner, D., Gelfi, Cecilia, Belavy, D.L., Rittweger, J., Borst, H., Heer, M., Heer, Martina, Rittweger, Jörn, Degner, Corinna, Kornak, Uwe, Armbrecht, Gabriele, Gast, U., Cerretelli, P., Gelfi, C., Beller, Gisela, Soll, H., Belavy, Daniel, Kornak, U., Felsenberg, Dieter   +42 more
core  

Polyphyllin I Ameliorates Collagen-Induced Arthritis by Suppressing the Inflammation Response in Macrophages Through the NF-κB Pathway

Frontiers in Immunology, 2018
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disorder, characterized by an increased number of M1-like macrophages in the joints. Polyphyllin I (PPI), one of the main components in the Rhizoma of Paris polyphyllin, displays a selective ...
Qiong Wang, Qiong Wang, Qiong Wang, Xin Zhou, Yongjian Zhao, Yongjian Zhao, Yongjian Zhao, Jun Xiao, Yao Lu, Qi Shi, Qi Shi, Qi Shi, Yongjun Wang, Yongjun Wang, Yongjun Wang, Yongjun Wang, Hongyan Wang, Qianqian Liang, Qianqian Liang, Qianqian Liang   +19 more
doaj   +1 more source

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

Association between vitamin D receptor gene polymorphism (rs731236) and aggrecan gene VNTR polymorphism with the risk of lumbar intervertebral disc degeneration

Caspian Journal of Internal Medicine, 2022
Background: Low back pain is one of the most common causes of referral to physicians. Lumbar disc degeneration (LDD) is the main cause of back pain in different countries. It seems that genetic factors are more effective than environmental factors in the
Kaveh Haddadi, Mohammad Sahebi, Abdolkarim Mahrooz, Masoud Shayestehazar, Mohammad Bagher Hashemi-Soteh   +4 more
doaj  

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

Dexime: A Selectively Enzyme‐Degradable Hydrogel for Protein Therapeutic Release

Advanced Materials, EarlyView.
A dextrin‐oxime hydrogel (dexime) is produced using ketone or aldehyde modified dextrin and tetra‐oxyamine modified poly(ethylene glycol). The rheological and mechanical properties of dexime are tunable. Dexime is injectable, cytocompatible, hydrolytically stable, and selectively degradable by α‐amylase.
Quinton E. A. Sirianni, Nitzan Letko Khait, Adam Forman, Edward A. Armstrong, Karim Fouad, Molly S. Shoichet   +5 more
wiley   +1 more source

N-methyl-D-aspartate (NMDA) receptor composition modulates dendritic spine morphology in striatal medium spiny neurons. [PDF]

, 2012
Dendritic spines of medium spiny neurons represent an essential site of information processing between NMDA and dopamine receptors in striatum. Even if activation of NMDA receptors in the striatum has important implications for synaptic plasticity and ...
P. Calabresi, C. Vastagh, Bagetta, Vincenza, V. Bagetta, E. Zianni, C. Giampà, M.M.G. Di Luca, Vastagh, Csaba, F. Gardoni, B. Picconi, J. Stanic, Gardoni, Fabrizio   +11 more
core   +1 more source