Results 131 to 140 of about 1,782,642 (314)

Spine surgery for metastatic spine cancer in the era of advanced radiation therapy

Metastatic spine cancer (MSC), a common complication of advanced malignancies, poses significant challenges due to pain, neurological deficits, and mechanical instability.
Hwang, Chang Ju, Cho, Jae Hwan, Park, Sehan, Lee, Dong-Ho   +3 more
core   +1 more source

A Single‐Amino‐Acid Ligand for LAT1: A Minimalist and Modular Platform for Lysosome‐Targeted Degradation of Membrane Proteins

Advanced Science, EarlyView.
LA‐LYTAC repurposes the cancer‐enriched amino acid transporter LAT1 as a lysosomal trafficking receptor for targeted membrane‐protein degradation. A single phenylalanine‐derived ligand, modularly linked to antibodies or small‐molecule binders, recruits PD‐L1, EGFR, or integrins to LAT1, triggering transporter‐mediated internalization, lysosomal ...
Liquan Zhu, Ke Liu, Haotian Liu, Chaoqi He, Xiaozhen Liu, Xin Zeng, Misha Mao, Yuxiao Mu, Ying Li, Qinghui Zheng, Hongchao Tang, Da Qian, Xuli Meng   +12 more
wiley   +1 more source

Endothelial YAP Signaling Promotes Blood‐Spinal Cord Barrier Repair in Mice After Spinal Cord Injury

Advanced Science, EarlyView.
Endothelial YAP is required for blood‐spinal cord barrier repair after spinal cord injury. YAP‐dependent vascular repair is associated with ANGPT1/PI3K/AKT signaling in vivo and may involve endothelial‐pericyte paracrine interactions. By supporting vascular remodeling, tight junction restoration, restored pericyte coverage, and astrocyte‐vascular ...
Jiawei Wang, Yaozhi He, Yanjiao Wang, Jingjing Zhang, Qishun Liang, Mengxian Jia, Yumin Wu, Zongjie Yuan, Ziwei Fan, Yuxuan Li, Huihui Zhang, Qinjiao Fu, Ying Wang, Zhihui Huang, Honglin Teng   +14 more
wiley   +1 more source

Differential Tissue‐Coupled Powering for Battery‐Free Injectable Electroceuticals

Advanced Science, EarlyView.
A thread‐like injectable neural stimulator is powered through differential tissue‐coupled powering (DTCP), which harvests RF‐frequency tissue potentials with an elongated receiver while preserving a injectable cross‐section. The system integrates an ASIC, stimulation electrodes, and a portable transmitter, enabling wireless peripheral nerve stimulation,
Han Wu, Sultan Mahmud, Mali Halac, Asif Iftekhar Omi, Domenica Sofia Baez Rodas, Jeremiasz Dados, Chaojun Cheng, Anyu Jiang, Cameron Wallace, Anvi Singh, Erin Patrick, Baibhab Chatterjee, Shriya Srinivasan, Adam Khalifa   +13 more
wiley   +1 more source

Rare Complications of Cervical Spine Surgery: Pseudomeningocoele.

, 2019
This study was a retrospective, multicenter cohort study.Rare complications of cervical spine surgery are inherently difficult to investigate. Pseudomeningocoele (PMC), an abnormal collection of cerebrospinal fluid that communicates with the subarachnoid
Smith, Zachary A, Lee, Sungho, Hsu, Wellington K, Fish, David E, Nassr, Ahmad, Traynelis, Vincent C, Massicotte, Eric M, Smith, Gabriel A, Hilibrand, Alan S, Corriveau, Mark, Sebastian, Arjun S, Pace, Jonathan, Ailon, Tamir, Lord, Elizabeth L, Riew, K Daniel, Steinmetz, Michael P, Than, Khoi D, Buser, Zorica, Wang, Jeffrey C, Mroz, Thomas E, Fehlings, Michael G, Chou, Dean, Shaffrey, Christopher, Sasso, Rick C, Arnold, Paul M, Smith, Justin S, Mummaneni, Praveen V   +26 more
core   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Dysphagia after anterior cervical spine surgery: a systematic review of potential preventative measures

, 2015
Background context Anterior cervical spine surgery is one of the most common spinal procedures performed around the world, but dysphagia is a frequent postoperative complication.
Joaquim, A.F., Patel, A.A., Murar, J., Savage, J.W.   +3 more
core   +1 more source

Effectiveness of Fu’s Subcutaneous Needling for Managing Postoperative Axial Symptoms After Cervical Laminoplasty: A Retrospective Observational Study

Journal of Pain Research
Hong-Zhen Li,1,* Yu-Qiao Li,2,* Peng-Hui Xia,3,* Yue-Jiao Zhang,4 Chong Zhao,1 Wei-Wei Xia,1 Yong-Hao Wu,1 Chen-Fei Zhang,1 Hai-Ying Liu,1 Pan-Feng Yu1 1Department of Spine Surgery, Peking University People’s Hospital, Beijing ...
Li HZ, Li YQ, Xia PH, Zhang YJ, Zhao C, Xia WW, Wu YH, Zhang CF, Liu HY, Yu PF   +9 more
doaj  

Prolonged operative time significantly impacts on the incidence of complications in spinal surgery

Journal of Orthopaedic Surgery and Research
Background In spinal surgery adverse events (AE) and surgical complications (SC) significantly affect patient’s outcome and quality of life. The duration of surgery has been investigated in different surgical field as risk factor for complications.
Annalisa Monetta, Cristiana Griffoni, Luigi Falzetti, Gisberto Evangelisti, Luigi Emanuele Noli, Giuseppe Tedesco, Carlotta Cavallari, Stefano Bandiera, Silvia Terzi, Riccardo Ghermandi, Marco Girolami, Valerio Pipola, Alessandro Gasbarrini, Giovanni Barbanti Brodano   +13 more
doaj   +1 more source

Stress Hyperglycemia Drives CD4+ T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

Advanced Science, EarlyView.
High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao, Xuemei Miao, Wei Luo, Tao Liu, Yang Wang, Jiaying Li, Di Fu, Weiyun Shen, Yan Luo, Kang Chen, Ruping Dai, Hui Li   +11 more
wiley   +1 more source