Results 141 to 150 of about 1,782,642 (314)

Targeted Decompression Under Local Anesthesia versus Extensive Decompression Under General Anesthesia for Octogenarians with Lumbar Degenerative Diseases: A Real-World Propensity Score-Matched Analysis

Clinical Interventions in Aging
Hang Zhang,1,* Huili Cai,2,* Yunzhong Cheng,3,* Xuelin Li,4,* Yang Liu,1 Fengping Liu,1 Jingchuan Sun,5 Haidan Chen1 1Department of Spine Surgery, Yichang Central People’s Hospital, First Clinical Medical College of China ...
Zhang H, Cai H, Cheng Y, Li X, Liu Y, Liu F, Sun J, Chen H   +7 more
doaj  

Engineering Ultrastable Intrinsic Radicals: Graphene Quantum Dots With NIR‐II Emission for Dynamic Deep‐Tissue Bioimaging

Advanced Science, EarlyView.
Stable radicals are attractive for photonic and quantum information technologies but are often limited by instability. We stabilize intrinsic radicals in graphene quantum dots via 2D polymerization of perylene derivatives, where bilayer defect confinement suppresses quenching (100–500 K).
Qin Xu, Yijie Hou, Bingzhe Wang, Tesen Zhang, Yupeng Liu, Shuaiqi Li, Maohua Chen, Guichuan Xing, Dongbo Guo, Songnan Qu   +9 more
wiley   +1 more source

Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain

Advanced Science, EarlyView.
Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan, Peiyi Li, Yufeng Chen, Zishan Dong, Yuanyuan Li, Boyu Liu, Yan Tai, Chuan Wang, Jianqiao Fang, Chengyu Yin, Boyi Liu   +10 more
wiley   +1 more source

Percutaneous Endoscopic Decompression versus Non-Operative Care for Radicular Pain in the Oldest-Old with Lumbar Stenosis: A Target Trial Emulation Focusing on Pain Relief and Deprescribing

Clinical Interventions in Aging
Miao Wang,1 Qiong Wang,2 Guang-Zhou Li,1 Fan-Dong Wang,1 Long Tang,1 Hao Zhang1 1Department of Spine Surgery, Suining Central Hospital, Suining, 629000, People’s Republic of China; 2Department of Pain Management, Suining Central Hospital, Suining, 629000,
Wang M, Wang Q, Li GZ, Wang FD, Tang L, Zhang H   +5 more
doaj  

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source

Success in Esophageal Perforation Repair With Open-Wound Management After Revision Cervical Spine Surgery

, 2015
Study Design. Case report. Objective. To share our successful experience in treating 1 case of esophageal perforation after anterior revision cervical spine surgery with open-wound management. Summary of Background Data.
Liu, Zhongjun, Ji, Hongquan, Liu, Dandan, You, Weitao, Zhou, Fang   +4 more
core   +1 more source

Alternating Shear Force of Respiration Regulates Cell Interactions of Fibroblasts and Macrophages to Promote Soft Tissue Integration of Chest Wall Polyetheretherketone Implants

Advanced Science, EarlyView.
Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang, Yangfan Huo, Jin Liu, Sida Liu, Minghai Ma, Hao Guo, Yuanquan Zhang, Xing Li, Xiao Liang, Jiawei Xiu, Ying Sun, Lijun Huang, Xiaolong Yan, Weiwei Wu, Lei Wang   +14 more
wiley   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

De novo spine surgery as a predictor of additional spine surgery at the same or distant spine regions

GMS German Medical Science, 2011
Introduction: Degenerative spine disorders are steadily increasing parallel to the aging of the population with considerable impact on cost and productivity. In this paper we study the prevalence and risk factors for multiple spine surgery and its impact
Tolaymat, Abdullah, Abbara, Moataz, Robinson III, Joe Sam, Walid, M. Sami, Robinson Jr, Joe Sam   +4 more
doaj  

Electronic Chip‐Mimetic Medical Implants for Controllable Sonothermal Treatments

Advanced Science, EarlyView.
Inspired by the thermal effect of working electronic chips, which consist of various heterostructures, an sonothermal‐responsive platform has been developed through constructing metal‐semiconductor interface on implants. Biofilm infection and deep vein thrombosis can be successfully treated by controllable ultrasound treatments.
Zhengdong Zhang, Pan Liu, Jie Lei, Shuchang Peng, Qiu Chen, Wei Guan, Yizhou Zhu, Gang Liu, Xiaobo Feng, Cao Yang, Lei Tan   +10 more
wiley   +1 more source