Results 61 to 70 of about 7,577 (219)

NaV1.7 mRNA and Protein Expression in Resident Neurons of the Human Spinal Dorsal Horn

Journal of Comparative Neurology, Volume 534, Issue 5, May 2026.
We identified Nav1.7 mRNA and protein in human spinal cord neurons, a subset of which co‐expressed putative projection neuron markers, TACR1 and GPR83. These neurons relay nociceptive signals from the periphery to the brain. While Nav1.7 loss‐of‐function mutations cause congenital insensitivity to pain, traditionally linked to sensory neurons, our ...
Stephanie Shiers, Nwasinachi A. Ezeji, Carla Lima‐Truax, Jeffrey L. Krajewski, Geoffrey Funk, Anna Cervantes, Peter Horton, Gregory Dussor, Stephanie Hennen, Theodore J. Price   +9 more
wiley   +1 more source

Mapping thalamic-anterior cingulate monosynaptic inputs in adult mice

Molecular Pain, 2022
The anterior cingulate cortex (ACC) is located in the frontal part of the cingulate cortex, and plays important roles in pain perception and emotion. The thalamocortical pathway is the major sensory input to the ACC.
Man Xue, Wan-Tong Shi, Si-Bo Zhou, Ya-Nan Li, Feng-Yi Wu, Qi-Yu Chen, Ren-Hao Liu, Zhao-Xiang Zhou, Yu-Xiang Zhang, Yu-Xin Chen, Fang Xu, Guo-Qiang Bi, Xu-Hui Li, Jing-Shan Lu, Min Zhuo   +14 more
doaj   +1 more source

Dysphagia as the Sole Presentation of Lateral Medullary Syndrome in an Octagerian: A Diagnostic Challenge

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Lateral medullary syndrome (LMS) or Wallenberg's syndrome is usually caused by a cerebrovascular accident of the vertebral artery or the posterior inferior cerebellar artery (PICA), leading to damage to the dorsolateral aspects of the medulla oblongata.
Abera Kuma, Bereket A. Tegene, Sosena Sheleme, Shamil Nuri, Abdulkerim Girma, Sinetibeb Tadesse Amsalu   +5 more
wiley   +1 more source

Direct comparison of Hoxb8-driven reporter distribution in the brains of four transgenic mouse lines: towards a spinofugal projection atlas

Frontiers in Neuroanatomy
IntroductionHox genes govern rostro-caudal identity along the developing spinal cord, which has a well-defined division of function between dorsal (sensory) and ventral (motor) halves.
Bridget N. Barraclough, Bridget N. Barraclough, W. Terrence Stubbs, Manon Bohic, Manon Bohic, Aman Upadhyay, Aman Upadhyay, Victoria E. Abraira, Victoria E. Abraira, Matt S. Ramer, Matt S. Ramer   +10 more
doaj   +1 more source

Electroacupuncture Modulates Multiple Pathways for Neuroprotection and Neurorepair in Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
EA exerts therapeutic effects in ischemic stroke through multiple mechanisms: it alleviates acute injury by suppressing neuroinflammation, excitotoxicity, oxidative stress, apoptosis, pyroptosis, ferroptosis, autophagy dysregulation, and blood–brain barrier disruption, while enhancing cerebral blood flow, angiogenesis, and neurogenesis to support ...
Mingyue Zhao, Hangyu Shen, Xu Yan, Xiang Gao, Yuchun Liu, Shengjun Zhou, Jingxian Sun, Jie Sun, Yi Huang   +8 more
wiley   +1 more source

Actions of opioids on primate spinothalamic tract neurons [PDF]

The Journal of Neuroscience, 1986
The effects of iontophoretically applied opiates were tested on 24 spinothalamic tract cells in 12 anesthetized monkeys. The drugs used were chosen because of their agonist actions on different classes of opiate receptors (mu, morphine; kappa, dynorphin; delta, methionine enkephalinamide; sigma, N-allylnormetazocine or SKF 10047 and phencyclidine). The
W S, Willcockson, J, Kim, H K, Shin, J M, Chung, W D, Willis   +4 more
openaire   +2 more sources

Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment

MedComm, Volume 7, Issue 4, April 2026.
Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Xiaofeng Dai, Chongxiang Wang, Ping Jiang, Xiaopeng Mei   +3 more
wiley   +1 more source

Contemporary and Emerging Therapies in the Management of Refractory Angina: A Clinical Review

Catheterization and Cardiovascular Interventions, Volume 107, Issue 4, Page 869-884, March 1, 2026.
ABSTRACT Refractory angina (RA) represents a growing challenge in clinical cardiology, particularly in patients with obstructive coronary artery disease (CAD) who remain symptomatic despite optimal medical therapy and who are not candidates for revascularization.
Alex Angers‐Goulet, Siddhartha Mengi, David Garcia Labbé, Can Manh Nguyen, Jean‐Michel Paradis   +4 more
wiley   +1 more source

Hyperhomocysteinemia presenting as Wallenberg syndrome: A report of two cases and review of literature

Medical Journal of Dr. D.Y. Patil University, 2015
Wallenberg syndrome or lateral medullary syndrome occurs due to infarction of the lateral medulla usually supplied by the posterior inferior cerebellar artery (PICA).
Puneet Chabbra, Nikhil Gupta, Arun Garg, Sakshi Khurana   +3 more
doaj   +1 more source

The cornucopia of central disinhibition pain – An evaluation of past and novel concepts

Neurobiology of Disease, 2020
Central disinhibition (CD), as applied to pain, decreases thresholds of endogenous systems. This provokes onset of spontaneous or evoked pain in an individual beyond the ability of the nervous system to inhibit pain resulting from a disease or tissue ...
Julia Forstenpointner, Delany Berry, Ralf Baron, David Borsook   +3 more
doaj   +1 more source