Results 41 to 50 of about 457,484 (165)

Organization and receptive fields of primate spinothalamic tract neurons

, 1975
A technique is described for recording from axons belonging to the spinothalamic tract of the monkey. The axons arose from cell bodies located within the spinal cord since the latency of orthodromic activation by afferents within the dorsal funiculus ...
A. E. Applebaum, W. D. Willis, J. E. Beall, R. D. Foreman   +3 more
core   +1 more source

Neuropathic Pain: From Mechanisms to Therapeutic Interventions

MedComm, Volume 7, Issue 10, October 2026.
Neuropathic pain arises from peripheral nerve injury, central sensitization, neurotransmitter imbalance, neuroimmune activation, and maladaptive circuit remodeling. Clinical phenotyping and multimodal imaging can identify dominant peripheral and central mechanisms.
Yaling Dai, Mengquan Tan, Man Yuan, Huixian Zhou, Qin Xie, Jiling Zeng, Yixin Yang, Xinran He, Siyuan Song   +8 more
wiley   +1 more source

Effects of dorsal column stimulation on primate spinothalamic tract neurons

, 1976
The effect of dorsal column stimulation on spinothalamic tract cells was investigated in anesthetized monkeys. The dorsal column stimuli were applied at midthoracic or at cervical levels of the cord, while the responses of spinothalamic tract cells of ...
J. D. Coulter, W. D. Willis, J. E. Beall, R. D. Foreman   +3 more
core   +1 more source

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, Volume 13, Issue 54, 28 September 2026.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

Variations on a Theme: Pure Sensory Stroke Syndromes Secondary to Lesions in the Spinothalamic Tract

Clinical Neuroimaging
Introduction Stroke is one of the leading causes of death and disability in the United States and its clinical presentation depends on which part of the brain is impacted.
Whitley Figge, Thomas C. Varkey, Milan Sivakumar, Luke Kloft, Tamim Sultani, Andrei V. Alexandrov   +5 more
doaj   +1 more source

Crosstalk Between Cortical Plasticity and Peripheral Nervous Injury: Insights, Mechanisms, and Future Directions

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Peripheral nerve injury induces dynamic cortical plasticity, driven by molecular mechanisms such as BDNF and neurotransmitter systems. This review synthesizes subtype‐specific plasticity patterns: compressive injuries trigger rapid reorganization, while metabolic neuropathies lead to maladaptive changes.
Cong Cheng, Dong Gao, Yaojie Shen, Xi Wang, Junxi Dai, Yaoxian Xiang, Zongyuan Jiang, Zongqi You, Junjian Jiang   +8 more
wiley   +1 more source

Hierarchically and Temporally Distinct Ca2+ Signaling Across Thalamic Nuclei During Nociceptive Stimulation

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Fiber photometry revealed Ca2+ dynamics across multiple thalamic nuclei during nociceptive stimulation. Notably, all recorded thalamic nuclei were activated by nociceptive stimulation. Moreover, medial thalamic nuclei exhibited markedly stronger Ca2+ responses than lateral nuclei, suggesting a medial‐lateral difference in thalamic responses.
Yao‐Hua Liu, Tian‐Yu Zhao, Jin Cheng, Li‐Ming Liu, Sha‐Sha Tao, Yu‐Jing Chen, Jia‐Qi Zhu, Fen‐Sheng Huang, Zhi‐Ping Cai, Fei Li, Yun‐Qing Li   +10 more
wiley   +1 more source

Responses of primate spinothalamic tract neurons to electrical stimulation of hindlimb peripheral nerves

, 1975
The responses of spinothalamic tract neurons were studied by extra- and intracellular recordings from the lumbosacral spinal cord in anesthetized rhesus monkeys (Macaca mulatta).
A. E. Applebaum, W. D. Willis, D. L. Trevino, J. E. Beall, R. D. Foreman   +4 more
core   +1 more source

Direct comparison of Hoxb8-driven reporter distribution in the brains of four transgenic mouse lines: towards a spinofugal projection atlas

Frontiers in Neuroanatomy
IntroductionHox genes govern rostro-caudal identity along the developing spinal cord, which has a well-defined division of function between dorsal (sensory) and ventral (motor) halves.
Bridget N. Barraclough, Bridget N. Barraclough, W. Terrence Stubbs, Manon Bohic, Manon Bohic, Aman Upadhyay, Aman Upadhyay, Victoria E. Abraira, Victoria E. Abraira, Matt S. Ramer, Matt S. Ramer   +10 more
doaj   +1 more source

Mapping thalamic-anterior cingulate monosynaptic inputs in adult mice

Molecular Pain, 2022
The anterior cingulate cortex (ACC) is located in the frontal part of the cingulate cortex, and plays important roles in pain perception and emotion. The thalamocortical pathway is the major sensory input to the ACC.
Man Xue, Wan-Tong Shi, Si-Bo Zhou, Ya-Nan Li, Feng-Yi Wu, Qi-Yu Chen, Ren-Hao Liu, Zhao-Xiang Zhou, Yu-Xiang Zhang, Yu-Xin Chen, Fang Xu, Guo-Qiang Bi, Xu-Hui Li, Jing-Shan Lu, Min Zhuo   +14 more
doaj   +1 more source