Results 31 to 40 of about 457,484 (165)

Spinal signalling of C-fiber mediated pleasant touch in humans

eLife, 2019
C-tactile afferents form a distinct channel that encodes pleasant tactile stimulation. Prevailing views indicate they project, as with other unmyelinated afferents, in lamina I-spinothalamic pathways.
Andrew G Marshall, Manohar L Sharma, Kate Marley, Hakan Olausson, Francis P McGlone   +4 more
doaj   +1 more source

History of Spinal Cord “Pain” Pathways Including the Pathways Not Taken

Frontiers in Pain Research, 2022
Traditional medical neuroanatomy/neurobiology textbooks teach that pain is generated by several ascending pathways that course in the anterolateral quadrant of the spinal cord, including the spinothalamic, spinoreticular and spinoparabrachial tracts. The
Allan Basbaum
doaj   +1 more source

Decreases in Dorsal Cervical Spinal Cord White Matter Tract Integrity Are Associated with Elevated Levels of Serum MicroRNA Biomarkers in NCAA Division I Collegiate Football Players

Neurotrauma Reports, 2021
This prospective, controlled, observational cohort study assessed the performance of a novel panel of serum microRNA (miRNA) biomarkers relative to findings on cervical spinal cord magnetic resonance imaging (MRI) in collegiate football players.
Linda Papa, Brian Johnson, Alexa E. Walter, James R. Wilkes, Barbara Knollmann-Ritschel, Manish Bhomia, Semyon M. Slobounov   +6 more
doaj   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Neuroanatomy education through the years: Revisiting the teaching slides used by Sir Wilfrid Edward Le Gros Clark

Journal of Anatomy, EarlyView.
This paper examines the life and legacy of British anatomist Sir Wilfrid Le Gros Clark through his neuroanatomical teaching collection at the University of Oxford. The authors catalogued 103 specimens and analyzed selected slides—including cases of multiple sclerosis, amyotrophic lateral sclerosis, tabes dorsalis, syringomyelia, and the pineal gland's ...
Shiva A. Nischal, Kush M. Kale, Katherine Tourigny, Mohammed Abuelem, Gretchen Greene, Rachel Walsh, Zoltán Molnár   +6 more
wiley   +1 more source

Not Hot, but Sharp: Dissociation of Pinprick and Heat Perception in Snake Eye Appearance Myelopathy

Frontiers in Neurology, 2018
Following a traumatic spinal cord injury, a 53-year-old male developed a central cord syndrome with at-level neuropathic pain. Magnetic resonance imaging revealed a classical “snake eye” appearance myelopathy, with marked hyperintensities at C5-C7 ...
Jan Rosner, Michèle Hubli, Pascal Hostettler, Catherine R. Jutzeler, Catherine R. Jutzeler, John L. K. Kramer, Armin Curt   +6 more
doaj   +1 more source

The contribution of peripheral nerves to the pleasure from scratching an itch: Evidence from a neuronopathy participant

The Journal of Physiology, EarlyView.
Abstract figure legend Acute itch was experimentally induced using histamine and cowage in control participants (with no neuronopathy) and in IW, a participant with a large‐fibre sensory neuronopathy resulting in the loss of Aβ afferent function below C3, at the same time as largely preserving Aδ and C‐fibre function.
Adarsh D. Makdani, Andrew G. Marshall, Jonathan Cole, Francis McGlone   +3 more
wiley   +1 more source

Gabapentinoids‐duloxetine combination therapy for chronic pain: A mechanism oriented rational to bridge theoretical knowledge and real life setting

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3333-3353, October 2026.
Chronic pain represents a complex debilitating condition that extends beyond the protective function of physiological pain, often persisting as an independent disease entity. Chronic primary and secondary pain syndromes reflect a multifaceted continuum involving nociceptive, neuropathic and nociplastic mechanisms.
Stefania Nobili, Maurizio Evangelista, Elena Lucarini, Elena G. Giugliano, Carla Ghelardini, Laura Micheli, Lorenzo Di Cesare Mannelli   +6 more
wiley   +1 more source

Brown-Séquard syndrome due to cervical disc herniation

Revista Cubana de Medicina Militar, 2022
Introduction: Brown-Séquard syndrome accounts for 1 to 4 % of all spinal cord injuries, very infrequent. It involves the lateral half of the spinal cord and the structures and/or functions of the dorsal segment, the corticospinal tract and the ...
Héctor Figueredo Acosta, Damarys Maidel Torres de los Rios   +1 more
doaj  

How Affective States Moderate the Relationship of Pain Catastrophizing With Pain Severity in Patients With Acute and Chronic Pain

Brain and Behavior, Volume 16, Issue 10, October 2026.
ABSTRACT Background Psychological factors, including mood, affect, and pain catastrophizing, critically influence pain perception. We aimed to examine the relationships of these factors with pain trajectories in both acute postsurgical pain (APSP) and chronic non‐cancer pain (CNCP) cohorts.
Quinte T. Y. Kuper, Jasmijn E. Willemen, Richel Lousberg, Ruud J. M. Severeijns, Therese A. M. J. van Amelsvoort, Andrea J. R. Balthasar   +5 more
wiley   +1 more source