Results 181 to 190 of about 4,814 (215)

Solubilization of 3H-spiperone binding sites from rat brain

Life Sciences, 1978
Abstract Preliminary evidence indicates that specific 3 H-spiperone binding sites from rat striatum and frontal cortex may be obtained in a solubilized form using digitonin. The ligand-macromolecular complex was separated from the free ligand by means of a gel-filtration procedure.
H, Gorissen, P M, Laduron
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125I-spiperone: A novel ligand for D2 dopamine receptors

Life Sciences, 1984
125I-Spiperone binds with high affinity (KD 0.3 nM) to a single specific site (Bmax 34 pmol/g wet weight) in homogenates of rat corpus striatum. Specific binding is about 40-60 percent of total binding and is displaced stereo-specifically by butaclamol and clopenthixol.
A L, Gundlach, B L, Largent, S H, Snyder
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Haloperidol and spiperone potentiate murine splenic B cell proliferation

Immunopharmacology, 1996
The neuroleptics haloperidol and spiperone potentiated anti-mu induced murine B-lymphocyte proliferation in vitro and lowered the threshold of anti-mu antibody needed to trigger proliferation. Because haloperidol and spiperone are best known for actions at D2, 5HT2, alpha 1 and sigma (sigma) receptors, a series of agonists and antagonists of these ...
Y, Liu, S A, Wolfe
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N-(3-[18F]fluoropropyl)-spiperone: The preferred 18F labeled spiperone analog for positron emission tomographic studies of the dopamine receptor

International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, 1988
The ligands currently used for PET studies of the dopamine receptor are fluorine-18-labeled spiperone (FSp) and carbon-11 or fluorine-18-labeled N-methyl-spiperone. All three of these ligands have drawbacks in either their chemical preparation or their biological behavior.
M.J. Welch, J.A. Katzenellenbogen, C.J. Mathias, J.W. Brodack, K.E. Carlson, D.Y. Chi, C.S. Dence, M.R. Kilbourn, J.S. Perlmutter, M.E. Raichle, M.M. Ter-Pogossian   +10 more
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Chronic proglumide increases [3H]spiperone binding in the rat brain

European Journal of Pharmacology, 1985
The cholecystokinin (CCK) antagonist, proglumide, administered chronically (41.0-53.5 mg/kg per day, 14 days) to rats via osmotic mini-pumps, produced a significant 13% increase in the number of [3H]spiperone labeled binding sites (Bmax) in the striatum. There was no associated change in the affinity (Kd) of [3H]spiperone for the striatal binding sites.
A J, Bean, W J, Baldy, G E, Martin
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[3H]spiperone binding in the nigrostriatal system in human brain

European Journal of Pharmacology, 1984
The characteristics of [3H]spiperone binding in human brain were compared in three areas of the nigrostriatal pathway: areas containing the nerve terminals (caudate nucleus, putamen and pallidum); the area containing the cell bodies (substantia nigra pars compacta); the area containing the dendrites (pars reticulata).
M, Ruberg, B, Bokobza, F, Javoy-Agid, J C, Montfort, Y, Agid   +4 more
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Synthesis of no-carrier-added N-([18F]fluoroalkyl)spiperone derivatives

International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, 1986
3-N-([18F]fluoroalkyl)spiperone derivatives (2,3) can be prepared by N-alkylation of spiperone (1) with fluoroalkyl halides. The fluoroalkylating species 2-[18F]fluoroethyl bromide (7), 3-[18F]fluoropropyl bromide (8) and 4-[18F]fluorobutyl bromide (9) were prepared by [18F]fluoride ion displacement of the corresponding trifluoromethanesulfonates ...
D Y, Chi, M R, Kilbourn, J A, Katzenellenbogen, J W, Brodack, M J, Welch   +4 more
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Alzheimer'S disease: Monoamines and spiperone binding reduced in nucleus basalis

Annals of Neurology, 1986
AbstractLevels of dopamine and serotonin, and of their precursors and metabolites, were measured in the nucleus basalis of Meynert (nbM) of patients with Alzheimer's disease and control patients. [3H]Spiperone binding to membrane homogenates of the nbM, indicative of both dopaminergic and serotonergic receptors, was also measured. The nbM from patients
D L, Sparks, W R, Markesbery, J T, Slevin   +2 more
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3H-spiperone binding capacity in mononuclear cells: A family study

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1993
1. A family study was carried out using a putative biological vulnerability trait in families of schizophrenics and schizoaffective indexprobands to investigate, if the clinical phenotype and a biological marker for schizophrenia are cosegregating within families. 2.
B, Bondy, M, Ackenheil, M, Ertl, G, Minelli, C, Mundt, B, Peuker, G, Schleuning, H, Sauer   +7 more
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Binding of3H-spiperone in the mouse brain after intraperitoneal injection

Bulletin of Experimental Biology and Medicine, 1985
In experiments on mice 3H-spiperone binding after intraperitoneal injection was studied. The binding of 3H-spiperone was saturable in the frontal cortex and subcortical structures, whereas in the cerebellum, the amount of radioactivity increased in a linear manner and was referred to as nonspecific binding.
A M, Zharkovskiĭ, T A, Zharkovskaia, K S, Chereshka   +2 more
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