Results 181 to 190 of about 4,488 (204)

N-(3-[18F]fluoropropyl)-spiperone: The preferred 18F labeled spiperone analog for positron emission tomographic studies of the dopamine receptor

International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, 1988
The ligands currently used for PET studies of the dopamine receptor are fluorine-18-labeled spiperone (FSp) and carbon-11 or fluorine-18-labeled N-methyl-spiperone. All three of these ligands have drawbacks in either their chemical preparation or their biological behavior.
John A. Katzenellenbogen, James W. Brodack, Joel S. Perlmutter, Carla J. Mathias, Michael J. Welch, Dae Yoon Chi, Michael R. Kilbourn, Carmen S. Dence, Marcus E. Raichle, Michel M. Ter-Pogossian, Kathryn E. Carlson   +10 more
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Effects of cations and temperature on the binding of [3H]spiperone to sheep caudate nucleus

Biochemical Pharmacology, 1983
The specific [3H]spiperone binding by sheep caudate nucleus homogenate is increased by divalent cations. The effect of Ca2+ or Mn2+ (5 mM) is temperature-dependent, and it is optimal at about 37 degrees, but is relatively low below 15 degrees and above 50 degrees.
A. Lajtha, C.R. Oliviera, Arsélio P. Carvalho, I. Wajda   +3 more
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Binding of3H-spiperone in the mouse brain after intraperitoneal injection

Bulletin of Experimental Biology and Medicine, 1985
In experiments on mice 3H-spiperone binding after intraperitoneal injection was studied. The binding of 3H-spiperone was saturable in the frontal cortex and subcortical structures, whereas in the cerebellum, the amount of radioactivity increased in a linear manner and was referred to as nonspecific binding.
K. S. Chereshka, Zharkovskaia Ta, A M Zharkovskiĭ   +2 more
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[3H] Spiperone Binding to Lymphocytes in Psychiatric Disorders

1990
There is ample evidence indicating that the central nervous system and the immune system are functionally linked. The exact mode of neural — immune interaction is still not certain, however the presence of specific neurotransmitter receptors on these cells appears to be important in mediating an intracellular event which could then lead to alterations ...
B. Peuker, B. Bondy, Manfred Ackenheil
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Solubilization of 3H-spiperone binding sites from rat brain

Life Sciences, 1978
Abstract Preliminary evidence indicates that specific 3 H-spiperone binding sites from rat striatum and frontal cortex may be obtained in a solubilized form using digitonin. The ligand-macromolecular complex was separated from the free ligand by means of a gel-filtration procedure.
Pierre M. Laduron, H. Gorissen
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Chronic proglumide increases [3H]spiperone binding in the rat brain

European Journal of Pharmacology, 1985
The cholecystokinin (CCK) antagonist, proglumide, administered chronically (41.0-53.5 mg/kg per day, 14 days) to rats via osmotic mini-pumps, produced a significant 13% increase in the number of [3H]spiperone labeled binding sites (Bmax) in the striatum. There was no associated change in the affinity (Kd) of [3H]spiperone for the striatal binding sites.
Gregory E. Martin, Andrew J. Bean, William J. Baldy   +2 more
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The effect of cholecystokinin octapeptide on rat striatal 3H spiperone binding

Biochemical Pharmacology, 1985
In the rat striatum sulphated CCK8 has no significant effect on equilibrium binding of 3H-spiperone but has a considerable, although transient, effect under non-equilibrium conditions. Under non-equilibrium conditions (during the association phase of ligand binding) and at high ligand concentrations (1 nM), CCK8 displaces specific binding and at low ...
Celestine T. O'Shaughnessy, Judith A. Poat, M.J. Turnbull   +2 more
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Comparison of 3H-spiperone binding in caudate nuclei of rabbits and rats

Pharmacology Biochemistry and Behavior, 1987
3H-Spiperone binding and inhibition by competing ligands were studied in caudate nucleus homogenates from Sprague-Dawley rats and New Zealand albino rabbits. 3H-Spiperone binding sites were very similar in the two species and had pharmacological profiles characteristic of D2-dopamine receptors, in accordance with previous reports.
Linda L. Hernandez, Donald A. Powell
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Synthesis of no‐carrier‐added radiobrominated N‐alkylated analogues of spiperone

Journal of Labelled Compounds and Radiopharmaceuticals, 1985
AbstractThe synthesis of a series of p‐bromo‐3‐N‐alkyl spiperone analogues is described. N‐alkylation was achieved via reaction of the potassium salt of the spiperone lactam ring with alkyl iodide; subsequent reactions with elemental bromine gave the p‐brominated isomers.
Gerhard Stöcklin, Peter Laufer, Stephen M. Moerlein   +2 more
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Haloperidol and spiperone potentiate murine splenic B cell proliferation

Immunopharmacology, 1996
The neuroleptics haloperidol and spiperone potentiated anti-mu induced murine B-lymphocyte proliferation in vitro and lowered the threshold of anti-mu antibody needed to trigger proliferation. Because haloperidol and spiperone are best known for actions at D2, 5HT2, alpha 1 and sigma (sigma) receptors, a series of agonists and antagonists of these ...
Seth A. Wolfe, Yuhong Liu
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