Results 191 to 200 of about 4,814 (215)
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Effect of mazindol on brain dopamine turnover in spiperone-treated rats
Journal of Neural Transmission, 1979Mazindol, an anorexic drug, caused a large increase in brain 3, 4-dihydroxyphenylacetic acid (DOPAC) concentration in spiperone-pretreated rats. The increase was dose-related over a 1--10 mg/kg dose range of mazindol and was maximum within 1 hour after maxzindol injection into rats pretreated 1 hour previously with spiperone.
R W, Fuller, H D, Snoddy
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The effect of cholecystokinin octapeptide on rat striatal 3H spiperone binding
Biochemical Pharmacology, 1985In the rat striatum sulphated CCK8 has no significant effect on equilibrium binding of 3H-spiperone but has a considerable, although transient, effect under non-equilibrium conditions. Under non-equilibrium conditions (during the association phase of ligand binding) and at high ligand concentrations (1 nM), CCK8 displaces specific binding and at low ...
C, O'Shaughnessy +2 more
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Dopamine D2 receptor binding in adrenal medulla: Characterization using [3H]spiperone
Biochemical Pharmacology, 1987The possibility that dopamine may function as a neuromodulator or neurotransmitter in the adrenal gland, and not merely serve as a precursor to the catecholamines, has been suggested. If this hypothesis is correct, receptors for dopamine should be identifiable in the adrenal.
M, Quik +3 more
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[3H] Spiperone Binding to Lymphocytes in Psychiatric Disorders
1990There is ample evidence indicating that the central nervous system and the immune system are functionally linked. The exact mode of neural — immune interaction is still not certain, however the presence of specific neurotransmitter receptors on these cells appears to be important in mediating an intracellular event which could then lead to alterations ...
B. Bondy, B. Peuker, M. Ackenheil
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Effects of spiperone on feeding performance in a food preference test
Psychopharmacology, 1979Spiperone reduced latency to feed and prolonged the total duration of feeding in a food-preference test in which novel and familiar foods were presented simultaneously to food-deprived rats. The increase in feeding duration could be accounted for in terms of an increase in time devoted to eating the novel foods, leaving the time devoted to eating the ...
S J, Cooper, K F, Sweeney, F M, Toates
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3H-Spiperone binding to peripheral mononuclear cells in psychiatric in-patients
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 19961. There is an ongoing controversy, if increased binding of 3H-spiperone to lymphocytes might discriminate between schizophrenia and other psychiatric diseases or even be a genetic vulnerability marker for schizophrenia, or predict the response to neuroleptic treatment. 2.
N, Wodarz, J, Fritze, P, Riederer
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[3H]Spiperone binding sites in brain: autoradiographic localization of multiple receptors
Brain Research, 1981[3H]Spiperone ([3H]SP) binding sites were localized by light microscopic autoradiography, after in vitro labeling. The kinetic and pharmacological characteristics of these binding sites were studied in slide-mounted sections of rat forebrain, and optimal labeling conditions were defined.
J M, Palacios, D L, Niehoff, M J, Kuhar
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[3H]Spiperone binding to lymphocyte in extrapyramidal disease and in aging
Brain, Behavior, and Immunity, 1987[3H]Spiperone binding to lymphocytes in Parkinson's disease (PD), Wilson's disease (WD), and age-matched control groups was studied. In the untreated PD group, [3H]spiperone binding was lower than in young controls, but did not differ from elderly healthy persons. After treatment with levodopa, the number of [3H]spiperone binding sites increased. In WD,
A, Członkowska +2 more
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Pharmacologic characterization of [3H]Dopamine and [3H]spiperone binding in mouse cerebellum
Neurochemistry International, 19921. [3H]Dopamine and [3H]spiperone binding to cerebellar homogenates was characterized utilizing dopaminergic agonists, antagonists and non-dopaminergic drugs. 2. The [3H]DA binding to low affinity binding sites reveals a heterogeneous population consisting of dopaminergic as well as serotonergic and noradrenergic sites.
N T, Panagopoulos, N A, Matsokis
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3H-spiperone binding in normal and schizophrenic post-mortem human brain
Life Sciences, 1978The neuroleptic ligand 3H-spiperone binds saturably to areas of human and rat brain which are rich in either dopamine (DA) or 5- hydroxytryptamine (5-HT). 2-Amino-6, 7-dihydroxytetralin (ADTN) and cinanserin were found to displace 3H-spiperone selectively from DA and 5-HT receptor sites respectively.
A V, Mackay +5 more
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