Results 111 to 120 of about 911,002 (345)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Driving unit design and motion analysis for a spiral propulsion mechanism in wetlands

Mechanical Engineering Journal, 2014
Environmental problems related to wetlands have attracted strong concern around the world during past decades. Mobile mechanisms of many kinds have been developed to satisfy demands of environmental investigation of wetlands.
Qunpo LIU, Naohiko HANAJIMA, Kunio KAWAUCHI, Toshiharu KAZAMA, Hidekazu KAJIWARA   +4 more
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

John Barth's "Dunyazadiad": A Postmodern Reading of an Eastern Frame

آداب الكوفة, 2017
The frame-tale technique is one of the most ancient narrative techniques, its roots go back to the oral tradition. It refers to a set of embedded stories which are encircled by a larger framework, hence creating a hierarchical pattern of stories within ...
Qassim Salman Sarhan, Marwa Ali Al-Shara
doaj   +1 more source

Quantum fluctuations in the spiral phase of the Hubbard model

, 1995
We study the magnetic excitations in the spiral phase of the two--dimensional Hubbard model using a functional integral method. Spin waves are strongly renormalized and a line of near--zeros is observed in the spectrum around the spiral pitch $\pm{\bf Q}$
C. Zhou, H. J. Schulz, H. J. Schulz, T. E. Mason, T. E. Mason   +4 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The Galactic Branches as a Possible Evidence for Transient Spiral Arms

, 2015
With the use of a background Milky-Way-like potential model, we performed stellar orbital and magnetohydrodynamic (MHD) simulations. As a first experiment, we studied the gaseous response to a bisymmetric spiral arm potential: the widely employed cosine ...
Gómez, Gilberto C., Pichardo, Bárbara, Pérez-Villegas, Angeles   +2 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

«Лабиринты» Молдажара

Искусство Евразии, 2018
В наскальном искусстве западной части хребта Тарбагатай (Восточный Казахстан) выявлены спиралевидные фигуры, которые, по-видимому, изображали лабиринты – такие фигуры достаточно распространены в петроглифах Евразии и обычно связываются с представлениями ...
Байтенов, Эскандер Муслимович
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source