Results 31 to 40 of about 23,483 (241)

The Regulatory Roles of Chemerin-Chemokine-Like Receptor 1 Axis in Placental Development and Vascular Remodeling During Early Pregnancy

Frontiers in Cell and Developmental Biology, 2022
Chemerin is an adipokine that regulates metabolism in pregnancy. An elevation of serum chemerin level is associated with pregnancy complications. Consistently, we demonstrated that the chemerin expression was increased in placenta of preeclamptic ...
Qingqing Zhang, Qingqing Zhang, Zhonglin Xiao, Cheuk-Lun Lee, Cheuk-Lun Lee, Yong-Gang Duan, Xiujun Fan, William S. B. Yeung, William S. B. Yeung, Philip C. N. Chiu, Philip C. N. Chiu, Jian V. Zhang, Jian V. Zhang, Jian V. Zhang   +13 more
doaj   +1 more source

Estrogen Actions in Placental Vascular Morphogenesis and Spiral Artery Remodeling: A Comparative View between Humans and Mice

Cells, 2023
Estrogens, mainly 17β-estradiol (E2), play a critical role in reproductive organogenesis, ovulation, and fertility via estrogen receptors. E2 is also a well-known regulator of utero-placental vascular development and blood-flow dynamics throughout ...
Mariam Rusidzé, Adrien Gargaros, Chanaëlle Fébrissy, Charlotte Dubucs, Ariane Weyl, Jessie Ousselin, Jacqueline Aziza, Jean-François Arnal, Françoise Lenfant   +8 more
doaj   +1 more source

Global sensitivity analysis based on Gaussian-process metamodelling for complex biomechanical problems [PDF]

Int J Numer Meth Biomed Engng. 2023;e3675, 2022
Biomechanical models often need to describe very complex systems, organs or diseases, and hence also include a large number of parameters. One of the attractive features of physics-based models is that in those models (most) parameters have a clear physical meaning.
arxiv   +1 more source

Increased angiogenic factor secretion by decidual natural killer cells from pregnancies with high uterine artery resistance alters trophoblast function. [PDF]

, 2014
STUDY QUESTION Are the concentrations of factors secreted by decidual natural killer (dNK) cells from pregnancies at high risk of poor spiral artery remodelling different to those secreted from pregnancies at low risk?
A. E. Wallace, A. P. Johnstone, Athanassiades, Cartwright, Choy, Desai, Engert, Fraser, Furuya, G. S. Whitley, Hanna, J. E. Cartwright, Karamouzis, Kim, King, King, Koga, Meekins, Melchiorre, Moroianu, Nasu, Pijnenborg, Pijnenborg, Pollheimer, Prefumo, Prefumo, R. Fraser, Rehn, S. Gurung, S. S. Goulwara, Santoni, Treiber-Held, van der Harten, Verma, Wei, Zhou   +35 more
core   +1 more source

Vitamin D Promotes Trophoblast Cell Induced Separation of Vascular Smooth Muscle Cells in Vascular Remodeling via Induction of G-CSF

Frontiers in Cell and Developmental Biology, 2020
Vitamin D deficiency is associated with complications of pregnancy such as pre-eclampsia, fetal growth restriction, and miscarriage, all of which are also associated with incomplete spiral artery (SpA) remodeling.
Joy Yue Zhang, Peihuang Wu, Danyang Chen, Fen Ning, Qinsheng Lu, Xiu Qiu, Martin Hewison, Jennifer A. Tamblyn, Mark D. Kilby, Mark D. Kilby, Gendie E. Lash   +10 more
doaj   +1 more source

Uterine Natural Killer Cells and Implantation

Fertility & Reproduction, 2021
Decidual leukocytes make up approximately 30% of all decidual stromal cells in early pregnancy, of which 70% are uterine natural killer (uNK) cells. uNK cells are phenotypically distinct from peripheral blood NK cells, being CD56brightCD16−.
Gendie E. Lash
doaj   +1 more source

A New Approach in Risk Stratification by Coronary CT Angiography. [PDF]

, 2014
For a decade, coronary computed tomographic angiography (CCTA) has been used as a promising noninvasive modality for the assessment of coronary artery disease (CAD) as well as cardiovascular risks.
Budoff, Matthew J, Nakanishi, Rine
core   +3 more sources

Downregulation of Cullin 3 Ligase Signaling Pathways Contributes to Hypertension in Preeclampsia

Frontiers in Cardiovascular Medicine, 2021
Background: Preeclampsia (PE) is a leading cause of maternal and perinatal morbidity and mortality; however, its etiology and pathophysiology remain obscure. PE is initiated by inadequate spiral artery remodeling and subsequent placental ischemia/hypoxia,
Ya Zhang, Gengru Jiang, Chong Zhang
doaj   +1 more source

Impaired decidual natural killer cell regulation of vascular remodelling in early human pregnancies with high uterine artery resistance [PDF]

, 2012
During human pregnancy, natural killer (NK) cells accumulate in the maternal decidua, but their specific roles remain to be determined. Decidual NK (dNK) cells are present during trophoblast invasion and uterine spiral artery remodelling.
Cartwright, JE, Fraser, R, Host, AJ, Johnstone, AP, Sebire, NJ, Thilaganathan, B, Whitley, GS   +6 more
core   +1 more source

Prevalence of placental bed spiral artery pathology in preeclampsia and fetal growth restriction:A prospective cohort study [PDF]

Background: Preeclampsia and fetal growth restriction (PE/FGR) are pregnancy complications known to be associated with poor utero-placental function due to abnormal “physiological” remodeling of spiral arteries and unfavorable maternal cardiovascular ...
Brouwers, Laura, de Gier, Steffie, Franx, Arie, Nikkels, Peter G.J., van Rijn, Bas B., Veerbeek, Jan H.W., Vogelvang, Tatjana E.   +6 more
core   +4 more sources