Results 31 to 40 of about 13,039 (280)

Understanding the uterine artery Doppler waveform and its relationship to spiral artery remodelling [PDF]

Placenta, 2021
Analysis of the uterine artery (UtA) Doppler waveform is frequently used in high-risk pregnancies to assess the likelihood of adverse pregnancy outcomes, including preeclampsia and fetal growth restriction. Whilst abnormal UtA waveforms at 18-20 weeks are associated with adverse outcomes, the underlying cause of these waveform changes remains unknown ...
Lloyd-Davies, Claire, Collins, Sally L, Burton, Graham J   +2 more
openaire   +3 more sources

MicroRNA-218-5p Promotes Endovascular Trophoblast Differentiation and Spiral Artery Remodeling. [PDF]

Mol Ther, 2018
Preeclampsia (PE) is the leading cause of maternal and neonatal morbidity and mortality. Defects in trophoblast invasion, differentiation of endovascular extravillous trophoblasts (enEVTs), and spiral artery remodeling are key factors in PE development.
Brkić J, Dunk C, O'Brien J, Fu G, Nadeem L, Wang YL, Rosman D, Salem M, Shynlova O, Yougbaré I, Ni H, Lye SJ, Peng C.   +12 more
europepmc   +4 more sources

Lymphatic mimicry in maternal endothelial cells promotes placental spiral artery remodeling. [PDF]

J Clin Invest, 2019
Molecular heterogeneity of endothelial cells underlies their highly specialized functions during changing physiological conditions within diverse vascular beds. For example, placental spiral arteries (SAs) undergo remarkable remodeling to meet the ever-growing demands of the fetus - a process which is deficient in preeclampsia.
Pawlak JB, Bálint L, Lim L, Ma W, Davis RB, Benyó Z, Soares MJ, Oliver G, Kahn ML, Jakus Z, Caron KM.   +10 more
europepmc   +5 more sources

Spiral Artery Remodeling in Preeclampsia Revisited [PDF]

Hypertension, 2013
See related article, pp 1046–1054 The first observations that placental bed defects were potentially linked to clinical outcomes such as preeclampsia (PE) were made nearly 50 years ago.1 This study followed prior findings that the placental clearance of radiolabeled saline was significantly decreased in women with hypertensive gestations.2 ...
Suzanne D, Burke, S Ananth, Karumanchi
openaire   +2 more sources

CT Diagnosis of Median Arcuate Ligament Compression Syndrome with Spontaneous Isolated Superior Mesenteric Artery Dissection: A Case Report

CT Lilun yu yingyong yanjiu, 2023
This article explores the CT findings and outcome of a case involving median arcuate ligament compression syndrome complicated with spontaneous isolated superior mesenteric artery dissection.
Xue HAN, Jinyong ZHAO, Zhaohui WANG, Dandan GENG   +3 more
doaj   +1 more source

Induced Human Decidual NK-Like Cells Improve Utero-Placental Perfusion in Mice. [PDF]

PLoS ONE, 2016
Decidual NK (dNK) cells, a distinct type of NK cell, are thought to regulate uterine spiral artery remodeling, a process that allows for increased blood delivery to the fetal-placental unit.
Ricardo C Cavalli, Ana Sofia Cerdeira, Elizabeth Pernicone, Henri A Korkes, Suzanne D Burke, Augustine Rajakumar, Ravi I Thadhani, Drucilla J Roberts, Manoj Bhasin, S Ananth Karumanchi, Hernan D Kopcow   +10 more
doaj   +1 more source

Uterine natural killer cells initiate spiral artery remodeling in human pregnancy [PDF]

The FASEB Journal, 2012
Uterine spiral artery remodeling is required for successful human pregnancy; impaired remodeling is associated with pregnancy complications, including late miscarriage, preeclampsia, and fetal growth restriction. The molecular triggers of remodeling are not known, but it is now clear that there are “trophoblast‐independent” and ...
Andrew Robson, Lynda K. Harris, Barbara A. Innes, Gendie E. Lash, Mais M. Aljunaidy, John Aplin, Philip N. Baker, Stephen C. Robson, Judith N. Bulmer   +8 more
openalex   +6 more sources

The role of extravillous trophoblasts and uterine NK cells in vascular remodeling during pregnancy

Frontiers in Immunology, 2022
Successful embryo implantation requires both a receptive endometrium and competent blastocysts. After implantation, the maternal decidua undergoes a series of changes, including uterine spiral artery (SA) remodeling to accommodate the fetus and provide ...
Xiao-Wei Wei, Xiao-Wei Wei, Xiao-Wei Wei, Xiao-Wei Wei, Yu-Chen Zhang, Fan Wu, Fu-Ju Tian, Fu-Ju Tian, Fu-Ju Tian, Fu-Ju Tian, Yi Lin   +10 more
doaj   +1 more source

Placental sFlt-1 Gene Delivery in Early Primate Pregnancy Suppresses Uterine Spiral Artery Remodeling.

Endocrinology, 2022
Abstract Uterine spiral artery remodeling (SAR) is essential for promoting placental perfusion and fetal development. A defect in SAR results in placental ischemia and increase in placental expression and serum levels of the soluble fms-like tyrosine kinase-1 (sFlt-1) receptor that binds to and suppresses vascular endothelial growth ...
Aberdeen GW, Babischkin JS, Lindner JR, Pepe GJ, Albrecht ED.   +4 more
europepmc   +3 more sources

The long noncoding RNA TARID regulates the CXCL3/ERK/MAPK pathway in trophoblasts and is associated with preeclampsia

Reproductive Biology and Endocrinology, 2022
Background The widely accepted explanation of preeclampsia (PE) pathogenesis is insufficient trophoblast invasion and impaired uterine spiral artery remodeling. However, the underlying molecular mechanism remains unclear.
Lingyun Liao, Min Liu, Yijie Gao, Xiaohong Wei, Yangxue Yin, Linbo Gao, Rong Zhou   +6 more
doaj   +1 more source