Regulation of Uterine Spiral Artery Remodeling: a Review [PDF]
Reproductive Sciences, 2020 AbstractExtravillous trophoblast remodeling of the uterine spiral arteries is essential for promoting blood flow to the placenta and fetal development, but little is known about the regulation of this process. A defect in spiral artery remodeling underpins adverse conditions of human pregnancy, notably early-onset preeclampsia and fetal growth ...
Eugene Albrecht +2 more
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MicroRNA-218-5p Promotes Endovascular Trophoblast Differentiation and Spiral Artery Remodeling [PDF]
Molecular Therapy, 2018 Preeclampsia (PE) is the leading cause of maternal and neonatal morbidity and mortality. Defects in trophoblast invasion, differentiation of endovascular extravillous trophoblasts (enEVTs), and spiral artery remodeling are key factors in PE development.
Lubna Nadeem +2 more
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B‐flow/spatiotemporal image correlation M‐mode: novel ultrasound method that detects decrease in spiral artery luminal diameter in first trimester in primate model of impaired spiral artery remodeling [PDF]
Ultrasound in Obstetrics and Gynecology, 2022 Sifa Turan, Eugene Albrecht
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The Effects of Hypertensive Disorders on Syncytiotrophoblast Cells and Spiral Artery Remodeling in Pregnancy [PDF]
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i BābulBackground and Objective: The major effect of the placenta is caused by the change of angiogenic factors in hypertensive disorders, which leads to chronic hypoxic changes in the placenta.
TH Khudir, RH Lateef, IA Salih
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Understanding the uterine artery Doppler waveform and its relationship to spiral artery remodelling [PDF]
Placenta, 2021 Analysis of the uterine artery (UtA) Doppler waveform is frequently used in high-risk pregnancies to assess the likelihood of adverse pregnancy outcomes, including preeclampsia and fetal growth restriction. Whilst abnormal UtA waveforms at 18-20 weeks are associated with adverse outcomes, the underlying cause of these waveform changes remains unknown ...
Lloyd-Davies, Claire +2 more
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Vascular smooth muscle cells during spiral artery remodeling in early human pregnancy†. [PDF]
Biol Reprod, 2021 Chen DB, Magness RR.
europepmc +6 more sources
Leukemia Inhibitory Factor (LIF) Inhibition during Mid-Gestation Impairs Trophoblast Invasion and Spiral Artery Remodelling during Pregnancy in Mice. [PDF]
PLoS ONE, 2015 The placenta forms the interface between the maternal and fetal circulation and is critical for the establishment of a healthy pregnancy. Trophoblast cell proliferation, migration and invasion into the endometrium are fundamental events in the initiation
Amy Winship +4 more
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MicroRNA‐590‐3p inhibits trophoblast‐dependent maternal spiral artery remodeling by repressing low‐density lipoprotein receptor‐related protein 6 [PDF]
Molecular Genetics & Genomic Medicine, 2018 Xiaoyan Yu
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Spiral Artery Remodeling in Preeclampsia Revisited [PDF]
Hypertension, 2013 See related article, pp 1046–1054 The first observations that placental bed defects were potentially linked to clinical outcomes such as preeclampsia (PE) were made nearly 50 years ago.1 This study followed prior findings that the placental clearance of radiolabeled saline was significantly decreased in women with hypertensive gestations.2 ...
Suzanne D, Burke, S Ananth, Karumanchi
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