Cross‐Species Insights into Trophoblast Invasion During Placentation Governed by Immune‐Featured Trophoblast Cells [PDF]
Advanced ScienceProper development of the placenta, the transient support organ forms after embryo implantation, is essential for a successful pregnancy. However, the regulation of trophoblast invasion, which is most important during placentation, remains largely ...
Linjun Hong
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Expression of CD82 in human trophoblast and its role in trophoblast invasion. [PDF]
PLoS ONE, 2012 BACKGROUND: Well-controlled trophoblast invasion at maternal-fetal interface is a critical event for the normal development of placenta. CD82 is a member of transmembrane 4 superfamily, which showed important role in inhibiting tumor cell invasion and ...
Qian Zhang +4 more
doaj +4 more sources
Elucidating the roles of microRNA-103a-3p in trophoblast invasion and SOX4-mediated extravillous differentiation induced by activin A [PDF]
Cell Death and DiseaseThe dysregulation of growth factors is associated with defective trophoblast invasion, which leads to uteroplacental malperfusion due to the inadequate remodeling of spiral arteries.
Jiamin Xie +5 more
doaj +2 more sources
Decidual derived exosomal miR-99a-5p targets Ppp2r5a to inhibit trophoblast invasion in response to CeO2NPs exposure [PDF]
Particle and Fibre Toxicology, 2023 Background The biological effects of cerium dioxide nanoparticles (CeO2NPs), a novel material in the biomedical field, have attracted widespread attention. Our previous study confirmed that exposure to CeO2NPs during pregnancy led to abnormal trophoblast
Hangtian Zhong +8 more
doaj +2 more sources
Trophoblast invasion biology: from normal implantation to accreta spectrum and choriocarcinoma [PDF]
Vascular BiologyTrophoblast invasion is a finely regulated physiological process that demonstrates controlled cellular migration and vascular remodeling during human pregnancy.
Mishu Mangla +3 more
doaj +2 more sources
Decidual Control of Trophoblast Invasion [PDF]
American Journal of Reproductive Immunology, 2016 At the time of implantation, the trophoblast cells of the embryo adhere and then invade into the maternal endometrium and eventually establish placentation. The endometrium at the same time undergoes decidualization, which is essential for successful pregnancy.
Geeta Godbole, Deepak Modi
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BMP6 as a therapeutic target for preeclampsia: enhancing trophoblast invasion and vascular mimicry [PDF]
Cellular and Molecular Life SciencesShallow trophoblast invasion and improper maternal spiral artery remodeling are the primary mechanisms underlying the development of preeclampsia (PE). Bone morphogenetic protein 6 (BMP6) is a proinvasive and proangiogenic factor in vitro; however, its ...
Yue Niu +10 more
doaj +2 more sources
A Microphysiological Model to Mimic the Placental Remodeling during Early Stage of Pregnancy under Hypoxia-Induced Trophoblast Invasion [PDF]
BiomimeticsPlacental trophoblast invasion is critical for establishing the maternal–fetal interface, yet the mechanisms driving trophoblast-induced maternal arterial remodeling remain elusive.
Seorin Jeong +4 more
doaj +2 more sources
Alteration of Pituitary Tumor Transforming Gene-1 Regulates Trophoblast Invasion via the Integrin/Rho-Family Signaling Pathway. [PDF]
PLoS ONE, 2016 Trophoblast invasion ability is an important factor in early implantation and placental development. Recently, pituitary tumor transforming gene 1 (PTTG1) was shown to be involved in invasion and proliferation of cancer.
Seung Mook Lim +6 more
doaj +1 more source
Trophoblasts, invasion, and microRNA [PDF]
Frontiers in Genetics, 2013 MicroRNAs (miRNAs) have recently become essential actors in various fields of physiology and medicine, especially as easily accessible circulating biomarkers, or as modulators of cell differentiation. To this respect, terminal differentiation of trophoblasts (the characteristic cells of the placenta in Therian mammals) into syncytiotrophoblast, villous
Doridot, Ludivine +3 more
openaire +4 more sources