Results 41 to 50 of about 21,086 (158)

miR21 modulates the Hippo signaling pathway via interference with PP2A Bβ to inhibit trophoblast invasion and cause preeclampsia

Molecular Therapy: Nucleic Acids, 2022
Preeclampsia (PE) is a pregnancy-specific disorder attributed to deficient extravillous trophoblast (EVT) invasion into the uterus, but the mechanism of EVT invasion remains unclear.
Mingyu Hu, Yangxi Zheng, Jiujiang Liao, Li Wen, Juan Cheng, Jiayu Huang, Biao Huang, Li Lin, Yao Long, Yue Wu, Xuan Ye, Yong Fu, Hongbo Qi, Philip N. Baker, Chao Tong   +14 more
doaj   +1 more source

Decreased placental IL9 and IL9R in preeclampsia impair trophoblast cell proliferation, invasion, and angiogenesis

Hypertension in Pregnancy, 2020
Objective Our study aimed to investigate IL9 and IL9R expression in preeclampsia and assess their effects on trophoblast biological behaviors. Methods IL9 and IL9R expression of placenta tissue were evaluated by immunochemistry and q-PCR. Using transwell,
Yi Sun, Siyu Liu, Rong Hu, Qiongjie Zhou, Xiaotian Li   +4 more
doaj   +1 more source

Trophoblast-derived Heparanase is Not Required for Invasion [PDF]

Placenta, 2008
To invade the decidua and myometrium, extravillous trophoblast must degrade an assortment of extracellular matrix (ECM) components. The uterine wall is rich in heparan sulphate proteoglycans (HSPG), which interact with collagen, laminin and fibronectin, and bind a variety of growth factors.
Harris, L. K.; id_orcid 0000-0001-7709-5202, Baker, P. N., Brenchley, P. E C; id_orcid 0000-0003-1290-9919, Aplin, J. D.; id_orcid 0000-0001-8777-9261   +3 more
openaire   +3 more sources

The role of progesterone in implantation and trophoblast invasion [PDF]

Journal of Reproductive Immunology, 2013
With its genomic and non-genomic actions, progesterone plays a role in preparing the endometrium for implantation and also in regulating trophoblast invasion and migration. The genomic actions of progesterone are mediated by the classical nuclear progesterone receptors, PR-A and PR-B. In addition to their genomic actions, nuclear progesterone receptors
Halasz, Melinda, Szekeres-Bartho, Julia
openaire   +4 more sources

Intrauterine Fate of Invasive Trophoblast Cells [PDF]

Placenta, 2009
Invasion of trophoblast cells into the uterine spiral arteries and the uterine wall is characteristic of hemochorial placentation. In the rat, trophoblast cells penetrate through the uterine decidua and well into the metrial gland. In this report, we examined the fate of these invasive trophoblast cells following parturition.
G X, Rosario, R, Ain, T, Konno, M J, Soares   +3 more
openaire   +2 more sources

α1,3-fucosylation of MEST promotes invasion potential of cytotrophoblast cells by activating translation initiation

Cell Death and Disease, 2023
Embryo implantation into the uterus is the gateway for successful pregnancy. Proper migration and invasion of embryonic trophoblast cells are the key for embryo implantation, and dysfunction causes pregnancy failure.
Hao Wang, Xinyuan Cui, Luyao Wang, Ningning Fan, Ming Yu, Huamin Qin, Shuai Liu, Qiu Yan   +7 more
doaj   +1 more source

Application of a JEG-3 organoid model to study HLA-G function in the trophoblast

Frontiers in Immunology, 2023
The human placenta is a unique temporary organ with a mysterious immune tolerance. The formation of trophoblast organoids has advanced the study of placental development.
Bai-Mei Zhuang, Bai-Mei Zhuang, Dan-Dan Cao, Xiao-Feng Liu, Li Wang, Xiao-Li Lin, Yong-Gang Duan, Cheuk-Lun Lee, Cheuk-Lun Lee, Philip C. N. Chiu, Philip C. N. Chiu, William S. B. Yeung, William S. B. Yeung, Yuan-Qing Yao, Yuan-Qing Yao, Yuan-Qing Yao   +15 more
doaj   +1 more source

Invasión trofoblástica en el embarazo normal (II): Placentación profunda (Trophoblastic invasion in normal pregnancy (II): Deep placentation)

Avances en Biomedicina, 2015
Deep placentation in human pregnancy is done by deep invasion of the placental bed by the extravillous trophoblast, involving the decidua and the inner (junctional zone) myometrium.
Eduardo Reyna-Villasmil, Carlos Briceño Pérez , Joel Santos-Bolívar   +2 more
doaj  

PPARgamma regulates trophoblast proliferation and promotes labyrinthine trilineage differentiation. [PDF]

PLoS ONE, 2009
BACKGROUND:Abnormal trophoblast differentiation and function is the basis of many placenta-based pregnancy disorders, including pre-eclampsia and fetal growth restriction. PPARgamma, a ligand-activated nuclear receptor, plays essential roles in placental
Mana M Parast, Heather Yu, Aleksandar Ciric, Mark W Salata, Vannessa Davis, David S Milstone   +5 more
doaj   +1 more source

Endometrial biology during trophoblast invasion

Frontiers in Bioscience, 2012
Attainment of successful implantation depends upon the synchronized changes in the endometrium before and after the arrival of blastocyst into the uterine cavity. The cues obtained from the receptive endometrium helps in proliferation and differentiation of the trophoblast cells.
Deepak Narhari, Modi, Geeta, Godbole, Pankaj, Suman, Satish Kumar, Gupta   +3 more
openaire   +2 more sources