Results 51 to 60 of about 21,086 (158)

DNA methyltransferases and TETs in the regulation of differentiation and invasiveness of extra-villous trophoblasts

Frontiers in Genetics, 2013
Specialised cell types of trophoblast cells form the placenta in which each cell type has particular properties of proliferation and invasion. The placenta sustains the growth of the fetus throughout pregnancy and any aberrant trophoblast differentiation
Philip Campbell Logan, Peter E Lobie, Murray David Mitchell   +2 more
doaj   +1 more source

Knockdown of DDX46 inhibits trophoblast cell proliferation and migration through the PI3K/Akt/mTOR signaling pathway in preeclampsia

Open Life Sciences, 2020
Preeclampsia (PE) is a serious disease during pregnancy associated with the dysfunction of trophoblast cell invasion. DDX46 is a kind of RNA helicase that has been found to regulate cancer cell metastasis. However, the role of DDX46 in PE remains unclear.
You Xin, Cui Hongyan, Yu Ning, Li Qiuli
doaj   +1 more source

An analysis of a mathematical model of trophoblast invasion

Applied Mathematics Letters, 2001
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Helen M. Byrne, Mark A. J. Chaplain, Graeme J. Pettet, D. L. Sean McElwain   +3 more
openaire   +5 more sources

Rac1/β-Catenin Signalling Pathway Contributes to Trophoblast Cell Invasion by Targeting Snail and MMP9

Cellular Physiology and Biochemistry, 2016
Background/Aims: Preeclampsia is an idiopathic and serious complication during gestation in which placental trophoblast cells differentiate into several functional subtypes, including highly invasive extravillous trophoblasts (EVTs).
Minghua Fan, Yongping Xu, Fanzhen Hong, Xiaolin Gao, Gang Xin, Haijie Hong, Lihua Dong, Xingbo Zhao   +7 more
doaj   +1 more source

Stromal resistance to placental invasion is a derived trait in ruminants

The Journal of Reproduction and Development
Placentation exhibits remarkable diversity among mammals, with reported correlations in cancer malignancy and invasiveness of placenta.
Wenqiang DU, Khadija WALI, Yasir SUHAIL, Yamin LIU, Bobbie EMERY, Günter P. WAGNER, KSHITIZ   +6 more
doaj   +1 more source

Mechanism of miR-20b-5p targeting HIF-1α in regulating trophoblast function in recurrent spontaneous abortion

European Journal of Medical Research
Objective Recurrent spontaneous abortion (RSA) is a major pregnancy complication with unclear pathogenesis. This study aims to investigate the role of miR-20b-5p and its downstream target HIF-1α in trophoblast function and RSA pathogenesis.
Yihong Guo, Qiaoxian Wu, Lujing Chen, Yanyu Lai, Aizhen Fu   +4 more
doaj   +1 more source

Down-Regulation of Neuropathy Target Esterase in Preeclampsia Placenta Inhibits Human Trophoblast Cell Invasion via Modulating MMP-9 Levels

Cellular Physiology and Biochemistry, 2018
Background/Aims: Neuropathy target esterase (NTE, also known as neurotoxic esterase) is proven to deacylate phosphatidylcholine (PC) to glycerophosphocholine as a phospholipase B.
Ting Zhong, Jiaxiang Chen, Yan Ling, Bei Yang, Xingxing Xie, Dainan Yu, Dalei Zhang, Jiexiu Ouyang, Haibin Kuang   +8 more
doaj   +1 more source

Decidual stromal cells-derived exosomes incured insufficient migration and invasion of trophoblast because of abnormal ubiquitination and degradation of Snail mediated by miR-92b-3p/USP28

BMC Biology
Background Recent findings have demonstrated that inadequate trophoblast migration and invasion are often responsible for the unsuccessful communication between the mother and fetus, contributing to URSA (unexplained recurrent spontaneous abortion ...
Miao Xiong, Ziqiu He, Liping Wen, Aimin Zhao   +3 more
doaj   +1 more source

Taxifolin Inhibits Invasion and Endovascular Differentiation of Extravillous Trophoblast HTR-8/SVneo Cells

Cells
Adequate placental development and function, prerequisites for the development of a healthy fetus, rely on controlled trophoblast invasion into the decidua and remodeling of the spiral arteries.
Aleksandra Vilotić, Janko Legner, Žanka Bojić-Trbojević, Marija Bruić, Biljana Spremo-Potparević, Milica Jovanović Krivokuća, Andrea Pirković   +6 more
doaj   +1 more source

Human placental trophoblast invasion and differentiation: a particular focus on Wnt signalling

Frontiers in Genetics, 2013
Wingless ligands, a family of secreted proteins, are critically involved in organ development and tissue homeostasis by ensuring balanced rates of stem cell proliferation, cell death and differentiation.
Martin eKnöfler, Jürgen ePollheimer
doaj   +1 more source