Results 31 to 40 of about 21,086 (158)

The BMP2 Signaling Axis Promotes Invasive Differentiation of Human Trophoblasts

Frontiers in Cell and Developmental Biology, 2021
Embryo implantation and trophoblast invasion are principal limiting factors of pregnancy establishment. Aberrant embryo development or improper trophoblast differentiation and invasion may lead to various unfavorable pregnancy-related outcomes, including
Jiali You, Jiali You, Wei Wang, Hsun-Ming Chang, Yuyin Yi, Hongjin Zhao, Hua Zhu, Yu Sun, Minyue Tang, Chunyan Wang, Yimiao Sang, Guofang Feng, Shaobing Cheng, Peter C. K. Leung, Yi-Min Zhu   +14 more
doaj   +1 more source

Inhibition of histone deacetylase activity in human endometrial stromal cells promotes extracellular matrix remodelling and limits embryo invasion.

PLoS ONE, 2012
Invasion of the trophoblast into the maternal decidua is regulated by both the trophoectoderm and the endometrial stroma, and entails the action of tissue remodeling enzymes.
Carlos Estella, Isabel Herrer, Stuart P Atkinson, Alicia Quiñonero, Sebastián Martínez, Antonio Pellicer, Carlos Simón   +6 more
doaj   +1 more source

Circular RNA hsa-circ-0005238 enhances trophoblast migration, invasion and suppresses apoptosis via the miR-370-3p/CDC25B axis

Frontiers in Medicine, 2022
BackgroundFetal growth restriction (FGR) is attributed to various maternal, fetal, and placental factors. Trophoblasts participate in the establishment and maintenance of pregnancy from implantation and placentation to providing nutrition to fetus ...
Zhuomin Huang, Litong Zhu, Quanfu Zhang, Depeng Zhao, Jilong Yao   +4 more
doaj   +1 more source

NOSTRIN: A novel modulator of trophoblast giant cell differentiation

Stem Cell Research, 2018
Differentiation-dependent expression of NOSTRIN in murine trophoblast cells prompted investigation on NOSTRIN's function in trophoblast differentiation. We show here that NOSTRIN levels increased in both mouse and rat placenta during gestation.
Shreeta Chakraborty, Rupasri Ain
doaj   +1 more source

CNN3 regulates trophoblast invasion and is upregulated by hypoxia in BeWo cells.

PLoS ONE, 2014
CNN3 is an ubiquitously expressed F-actin binding protein, shown to regulate trophoblast fusion and hence seems to play a role in the placentation process.
Sarah Appel, Janina Ankerne, Jan Appel, Andre Oberthuer, Peter Mallmann, Jörg Dötsch   +5 more
doaj   +1 more source

Long noncoding RNA SNHG12 promotes the proliferation, migration, and invasion of trophoblast cells by regulating the epithelial–mesenchymal transition and cell cycle

Journal of International Medical Research, 2020
Objective The deficient placental blood perfusion caused by the attenuated infiltration of trophoblast cells is a key factor in the occurrence of preeclampsia (PE).
Fenmei Zhou, Yanlan Sun, Zhenjing Chi, Qiong Gao, Hairong Wang   +4 more
doaj   +1 more source

Investigation of human trophoblast invasion in vitro [PDF]

Human Reproduction Update, 2020
Abstract BACKGROUND In humans, inadequate trophoblast invasion into the decidua is associated with the ‘great obstetrical syndromes’ which include pre-eclampsia, foetal growth restriction (FGR) and stillbirth.
Abbas, Yassen, Turco, Margherita Y, Burton, Graham J, Moffett, Ashley   +3 more
openaire   +2 more sources

Inverted formin 2 regulates intracellular trafficking, placentation, and pregnancy outcome

eLife, 2018
Healthy pregnancy depends on proper placentation—including proliferation, differentiation, and invasion of trophoblast cells—which, if impaired, causes placental ischemia resulting in intrauterine growth restriction and preeclampsia.
Katherine Young Bezold Lamm, Maddison L Johnson, Julie Baker Phillips, Michael B Muntifering, Jeanne M James, Helen N Jones, Raymond W Redline, Antonis Rokas, Louis J Muglia   +8 more
doaj   +1 more source

Extravillous Trophoblast Migration and Invasion Assay [PDF]

BIO-PROTOCOL, 2013
Extravillous trophoblast (EVT) migration and invasion through the decidualized endometrium is essential to successful placentation. SGHPL-4 cells, an EVT cell line derived from first trimester placenta, is a widely used model of cytotrophoblast differentiation into an invasive phenotype.
Magdalena Angelova, Heather Machado, Kenneth Swan, Cindy Morris, Deborah Sullivan   +4 more
openaire   +3 more sources

Time-resolved monitoring and circuit modeling of trophoblast invasion in a model of human embryo implantation by electric cell-substrate impedance sensing

Biosensors and Bioelectronics: X
Electric Cell-substrate Impedance Sensing (ECIS) is widely applied as a label-free and non-invasive technology for the in vitro monitoring of tissue dynamics through various electrical parameters.
Dongyang Tang, Liubov Izmaylova, Anil Can, Sven Ingebrandt, Rudolf E. Leube, Ziyu Gao   +5 more
doaj   +1 more source